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Protein

Anaphase-promoting complex subunit 1

Gene

anapc1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DDI-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-DDI-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-DDI-176408 Regulation of APC/C activators between G1/S and early anaphase
R-DDI-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-DDI-176412 Phosphorylation of the APC/C
R-DDI-179409 APC-Cdc20 mediated degradation of Nek2A
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 1
Short name:
APC1
Gene namesi
Name:anapc1
Synonyms:apc1
ORF Names:DDB_G0285349
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285349 anapc1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003282751 – 2269Anaphase-promoting complex subunit 1Add BLAST2269

Proteomic databases

PaxDbiQ54NC6
PRIDEiQ54NC6

Interactioni

Subunit structurei

The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: anapc1, anapc2, anapc3, anapc4, anapc5, anapc6, anapc7, anapc8, anapc10, anapc11, cdc20, cdc26 and cdh1.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0234263

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1440 – 1472PC 1Add BLAST33
Repeati1483 – 1520PC 2Add BLAST38
Repeati1605 – 1637PC 3Add BLAST33
Repeati1722 – 1756PC 4Add BLAST35
Repeati1792 – 1807PC 5Add BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 28Poly-Asn9
Compositional biasi142 – 150Poly-Gln9
Compositional biasi253 – 260Poly-Asn8
Compositional biasi311 – 326Poly-AsnAdd BLAST16
Compositional biasi387 – 393Poly-Asn7
Compositional biasi396 – 411Poly-AsnAdd BLAST16
Compositional biasi421 – 430Poly-Gln10
Compositional biasi519 – 526Poly-Asn8
Compositional biasi605 – 639Poly-AsnAdd BLAST35
Compositional biasi712 – 723Poly-AsnAdd BLAST12
Compositional biasi809 – 852Poly-AsnAdd BLAST44
Compositional biasi1957 – 1995Poly-AsnAdd BLAST39
Compositional biasi2140 – 2149Poly-Asn10
Compositional biasi2228 – 2236Poly-Asn9

Sequence similaritiesi

Belongs to the APC1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1858 Eukaryota
ENOG410XQ83 LUCA
InParanoidiQ54NC6
KOiK03348
OMAiAIAEWMQ
PhylomeDBiQ54NC6

Family and domain databases

InterProiView protein in InterPro
IPR024990 Apc1
PANTHERiPTHR12827 PTHR12827, 1 hit

Sequencei

Sequence statusi: Complete.

Q54NC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSIINLGKV KPFGLSYIIN SNNNNNNNDD DDYNNEIRES ESSIPYEYYF
60 70 80 90 100
CQNPLKSCFN EEQKILLQSE NDETDEKGMI LVNNSFFEEA QLFWYQNTVV
110 120 130 140 150
WSSPFTVKKK FTLPLLLSSM IYPKINNAIW SHFPFLKDLS KQQQEQQQQQ
160 170 180 190 200
HHQQSEYTTS SINNDIDDYY KYLCVLHNQG LNIYNSIGNS YQIVLPCKVI
210 220 230 240 250
NIWSSKFGLL LERDSSLDST LLAGRDRSEI PSIFSILNPL EELKPVLTFS
260 270 280 290 300
KSNNNNNNNN EALQQEFFSD TNQTIVFSST DYPILITYSN IENVHIIYQV
310 320 330 340 350
SHVKPSSNAE NDNTNNNNNN NNTNTNISNN QTINNENGTT TTIINNSSIV
360 370 380 390 400
NTSKPIFNFN NVSVNDQSFD YSNINISSSS PPFSSRNNNN NNNISNNNNT
410 420 430 440 450
NNNTNNNNTN NSTSMMQQSI QQQQQQQQQQ ENSSFKFLNE DKSYFFDDES
460 470 480 490 500
EFIIKSEIIF EEVLKDSTRL KSNTKSKSIF ITLDNNQKPL LCIEINSTLF
510 520 530 540 550
CYNLFIDQKI KSTQSSSSNK NNNNNNDRNE GIEEKLKLEF SFSISSVQSS
560 570 580 590 600
SPIFIESFYN NNEYTIPKGI NQPFIPLPTH ILVLNDHLLS VYWGPFKILD
610 620 630 640 650
LPIDNNSNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNK RKPLYIKDST
660 670 680 690 700
FNRVTIVYSD KEEIRFKITL GKSYLVSSCL GALSSFIPMN LLASIYQDFN
710 720 730 740 750
DFHKFRINNL LNSNSNNNNN NNNSEEENDK EWISFQILLI SLLEKSLLKR
760 770 780 790 800
PTDADTNKKI KENNHIKKEE NEDDWEFLLN SNYHKNYEKG LSFLSNLNIS
810 820 830 840 850
DSSKVYPSNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
860 870 880 890 900
CNIFIESIND FNFKTSLNSF IESIDDIIIA LHHQYEEFKI LTFNINYIYK
910 920 930 940 950
LSKFLIQLSL HLELFNYVDY YFRDFGDLID FINQFKIKSK TSIDISSLKL
960 970 980 990 1000
QSLLNDDIFS IYKFVYNSFN ENNSETQQQQ QFNKEKFERN KLTKYHFKWI
1010 1020 1030 1040 1050
YKMKSLYSIQ SKINDNNSNN KNNIKYISEK LIMKMVELDI KLEDLNSISF
1060 1070 1080 1090 1100
GLSLPLRESI KYCRSNPPID WPLKAYSLIE REELIYKFNI DDVNNVKDGL
1110 1120 1130 1140 1150
KINSLLISGG KNKLLSNSTM NHGYNSLSTS ITNTLSTASS SSNEMNSNSN
1160 1170 1180 1190 1200
ITSINGQSNG LPMNSTTNQM NSHQINNNGG GGGGGDDHHH HHSNSTSFDL
1210 1220 1230 1240 1250
SKFYHGQDEF YKRITYLRFD TDQRIQEVYR LLSFSNRIQI NHTQENGVSD
1260 1270 1280 1290 1300
HDYLSQLQSK LLLSVQRSIS LPIACGMFTI RSIKPLPTET INIPPIILNG
1310 1320 1330 1340 1350
FVGGTKTNIS LDPTMVQDNM MVWPEFHNGV AAGLKVSADQ TEITNTWIIY
1360 1370 1380 1390 1400
NRPKQFNPSY SGLLMALGLQ KRLSSLAFTK LFEYLASGHQ LTSVGLLLGI
1410 1420 1430 1440 1450
SCTKMGTMDM SIAKVLSVHI QSLHPPLSID LDVPSYVQIA ALMGIGLLYC
1460 1470 1480 1490 1500
QTSNRRMTEV LLMEIGRKPI NDKPLDRDSY SLTAGMALGL VNLGKGANEG
1510 1520 1530 1540 1550
SLTDLHVEDR LRSFIGISKE DSFDHMSTFF NQSYSTPSIS SNRNNNDLFN
1560 1570 1580 1590 1600
NGSNNNSSSN GGGGGGGGNN NGNNSNNGNN GSSQFKKSNT ILESSKPNID
1610 1620 1630 1640 1650
LTAPGAIIAL SLIYLKTNNL KISNYLSIPD TTFGLNYIRP DLVLLRILGR
1660 1670 1680 1690 1700
NLILWDSIKP QFQWIIDSVP LVVRKNVTID RNSEKVFQEH SNNNNNNNKS
1710 1720 1730 1740 1750
RSSSSLNDFE SFILIFCNVI AGAAFSIGLK YAGSLNENAF SLLMDLIQLF
1760 1770 1780 1790 1800
RKRQVYLNKC LLKKKKIEPT FDKVMRVTTE TCLNVVALSL SLVMAGSGNL
1810 1820 1830 1840 1850
ETLKILRMLR SRIGNEITYG NHMAINMAIG FLFLGGGQYT LSTSNIAIAS
1860 1870 1880 1890 1900
LVCSLYPRFP CSSTDNDYHL QAFRHLYFLA IDPRCLITRD VDTLAPCHVP
1910 1920 1930 1940 1950
IELTILNNDT MKLETKQLVT PCLIPELSSI RSISIKSPRY WNIFINRGFV
1960 1970 1980 1990 2000
DGGVDININN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNKNILKNH
2010 2020 2030 2040 2050
PTIFLKRKIG HLPYTEDPEG FRSLSKSFPK SESISLYSSS KGFQKNKEEF
2060 2070 2080 2090 2100
LKSFISDPNL LAFAKHFCTN QSNEFEHFNT TILYECLTQD TPEVIPLLLL
2110 2120 2130 2140 2150
LNDIANNFEK YSNSNTTIVL ENLRIIFKFY SKWNNGYYLN NNNNKNNNND
2160 2170 2180 2190 2200
GWLIHSTFLD SISTKIDEHF EKHFLNEQSN KKLLSNYLLT GELPNSLSTS
2210 2220 2230 2240 2250
IKRKFASFIS YYNLPNNKQF QSFKSLLNNN NNNNSNAIYQ LWSSLGNQIN
2260
FNSINKIIEL STLSFDEDS
Length:2,269
Mass (Da):258,585
Last modified:May 24, 2005 - v1
Checksum:iE18033096FA6F04A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000079 Genomic DNA Translation: EAL64749.1
RefSeqiXP_638254.1, XM_633162.1

Genome annotation databases

EnsemblProtistsiEAL64749; EAL64749; DDB_G0285349
GeneIDi8625062
KEGGiddi:DDB_G0285349

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000079 Genomic DNA Translation: EAL64749.1
RefSeqiXP_638254.1, XM_633162.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0234263

Proteomic databases

PaxDbiQ54NC6
PRIDEiQ54NC6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL64749; EAL64749; DDB_G0285349
GeneIDi8625062
KEGGiddi:DDB_G0285349

Organism-specific databases

dictyBaseiDDB_G0285349 anapc1

Phylogenomic databases

eggNOGiKOG1858 Eukaryota
ENOG410XQ83 LUCA
InParanoidiQ54NC6
KOiK03348
OMAiAIAEWMQ
PhylomeDBiQ54NC6

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-DDI-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-DDI-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-DDI-176408 Regulation of APC/C activators between G1/S and early anaphase
R-DDI-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-DDI-176412 Phosphorylation of the APC/C
R-DDI-179409 APC-Cdc20 mediated degradation of Nek2A
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q54NC6

Family and domain databases

InterProiView protein in InterPro
IPR024990 Apc1
PANTHERiPTHR12827 PTHR12827, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPC1_DICDI
AccessioniPrimary (citable) accession number: Q54NC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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