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UniProtKB - Q54N83 (SYLC_DICDI)
Protein
Leucine--tRNA ligase, cytoplasmic
Gene
leuS
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Catalytic activityi
- EC:6.1.1.4
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 714 | ATPBy similarity | 1 |
GO - Molecular functioni
- aminoacyl-tRNA editing activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- leucine-tRNA ligase activity Source: dictyBase
GO - Biological processi
- leucyl-tRNA aminoacylation Source: dictyBase
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)Alternative name(s): Leucyl-tRNA synthetase Short name: LeuRS |
Gene namesi | Name:leuS ORF Names:DDB_G0285451 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0285451, leuS |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: dictyBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328291 | 1 – 1058 | Leucine--tRNA ligase, cytoplasmicAdd BLAST | 1058 |
Proteomic databases
PaxDbi | Q54N83 |
PRIDEi | Q54N83 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 48 – 58 | 'HIGH' regionBy similarityAdd BLAST | 11 | |
Motifi | 711 – 715 | 'KMSKS' regionBy similarity | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.Curated
Phylogenomic databases
eggNOGi | KOG0437, Eukaryota |
HOGENOMi | CLU_004174_1_1_1 |
InParanoidi | Q54N83 |
OMAi | RWQFNHL |
PhylomeDBi | Q54N83 |
Family and domain databases
Gene3Di | 3.40.50.620, 1 hit 3.90.740.10, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR002300, aa-tRNA-synth_Ia IPR004493, Leu-tRNA-synth_Ia_arc/euk IPR013155, M/V/L/I-tRNA-synth_anticd-bd IPR015413, Methionyl/Leucyl_tRNA_Synth IPR014729, Rossmann-like_a/b/a_fold IPR009080, tRNAsynth_Ia_anticodon-bd IPR009008, Val/Leu/Ile-tRNA-synth_edit |
PANTHERi | PTHR45794, PTHR45794, 1 hit |
Pfami | View protein in Pfam PF08264, Anticodon_1, 1 hit PF00133, tRNA-synt_1, 2 hits PF09334, tRNA-synt_1g, 1 hit |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF50677, SSF50677, 1 hit |
TIGRFAMsi | TIGR00395, leuS_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54N83-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTAKLDFVR AYEKEVQNKW ESDKQFEIDA LDAPDAEHPK YLATFPYPYM
60 70 80 90 100
NGRLHVGHVF TITKAEFMCQ FQRLMGKRVL FPFAFHCTGM PIKACADKLK
110 120 130 140 150
KEIEQFGCPP VFPVIEEKPI QEVTTAVKED PLSFKSKKTK AVAKSGGAVY
160 170 180 190 200
QWKIMQSLGI SDEEIPMFAD SAYWLNYFPP HCESDLKLLG VGVDWRRSFI
210 220 230 240 250
TTDVNGYYDS FVRWQFESLK ALGKVKYGKR YSIWSTIDDQ QCADHERAQG
260 270 280 290 300
EGVGPQNYTL IKLEVVEPIP ECLKEIHSQG KKIYLVPGTL RPETMYGQTN
310 320 330 340 350
CWILPTGKYG AFEMANGDIF VCTERSARNM SYQQMTTGKG EYKCLAKFEG
360 370 380 390 400
SDILGAALKA PLAINPIVYV LPMLTIDENK GTGVVTSVPS DSPDDYASLQ
410 420 430 440 450
DLKAKAPLRA KFSIKDEWVL PFEVVPIIDI PGYSNESAVR AYKDLGIKSQ
460 470 480 490 500
NDRALLDQAK DLCYQKGFND GVMSVGPYAG RKVSEVKKII KDEMVASGQA
510 520 530 540 550
VDYSEPTSKV VSRSGDECVV ALSDQWYINY GDDDIEWKNQ TIKQLESMEF
560 570 580 590 600
YSAETKKKFE IALGWMNQWA CSRSFGLGTH LPWDEKFLIE SLSDSTIYMA
610 620 630 640 650
FYTVAHLLQG DVNGSKPGSA GITPKQMTSA CWDYVLMGKP YPEGCEVSEE
660 670 680 690 700
KLKELKKEFT YWYPVDIRVS GADLIQNHLT FFLYTHAAIF EKKFQPKSIR
710 720 730 740 750
ANGFVNLNGE KMSKSTGNFL TLVDSVAKFS ADGTRVALAD AGDSIEDANF
760 770 780 790 800
VDQTAVTSLL KLHTQIQWVQ ETLDSIDKFR SGPLDRIQDT IFESEINNII
810 820 830 840 850
VESEKAYQKT NFRDALHLVF FDLQNARDHY KVTTLDQMHK DLVLRFIEVQ
860 870 880 890 900
ALLIYPIAPH FAQKLFNMLG KGNILSAGWP KAGAIDYEAL KKNNYVQQTI
910 920 930 940 950
YNFRMKLQVY QKAKLKGKPA GTKAIPDQST IIVSKSYPKW QQDVLEYLAT
960 970 980 990 1000
IYNEDSKSFT KDNNAIAEEL LSREEMKPHK KNLMGFVASA IQNVKESGKD
1010 1020 1030 1040 1050
ALQTSLSFDE TSTLTDNIDY ICKTLELTSF DVKDFNEIPQ ASQSKIQPIP
GKPQFQFV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000079 Genomic DNA Translation: EAL64563.1 |
RefSeqi | XP_638060.1, XM_632968.1 |
Genome annotation databases
EnsemblProtistsi | EAL64563; EAL64563; DDB_G0285451 |
GeneIDi | 8625106 |
KEGGi | ddi:DDB_G0285451 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000079 Genomic DNA Translation: EAL64563.1 |
RefSeqi | XP_638060.1, XM_632968.1 |
3D structure databases
SMRi | Q54N83 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0231253 |
Proteomic databases
PaxDbi | Q54N83 |
PRIDEi | Q54N83 |
Genome annotation databases
EnsemblProtistsi | EAL64563; EAL64563; DDB_G0285451 |
GeneIDi | 8625106 |
KEGGi | ddi:DDB_G0285451 |
Organism-specific databases
dictyBasei | DDB_G0285451, leuS |
Phylogenomic databases
eggNOGi | KOG0437, Eukaryota |
HOGENOMi | CLU_004174_1_1_1 |
InParanoidi | Q54N83 |
OMAi | RWQFNHL |
PhylomeDBi | Q54N83 |
Miscellaneous databases
PROi | PR:Q54N83 |
Family and domain databases
Gene3Di | 3.40.50.620, 1 hit 3.90.740.10, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR002300, aa-tRNA-synth_Ia IPR004493, Leu-tRNA-synth_Ia_arc/euk IPR013155, M/V/L/I-tRNA-synth_anticd-bd IPR015413, Methionyl/Leucyl_tRNA_Synth IPR014729, Rossmann-like_a/b/a_fold IPR009080, tRNAsynth_Ia_anticodon-bd IPR009008, Val/Leu/Ile-tRNA-synth_edit |
PANTHERi | PTHR45794, PTHR45794, 1 hit |
Pfami | View protein in Pfam PF08264, Anticodon_1, 1 hit PF00133, tRNA-synt_1, 2 hits PF09334, tRNA-synt_1g, 1 hit |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF50677, SSF50677, 1 hit |
TIGRFAMsi | TIGR00395, leuS_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYLC_DICDI | |
Accessioni | Q54N83Primary (citable) accession number: Q54N83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries - Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - SIMILARITY comments
Index of protein domains and families