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Protein

Mitochondrial substrate carrier family protein B

Gene

mcfB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi53 – 641PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi90 – 1012PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial substrate carrier family protein B
Gene namesi
Name:mcfB
ORF Names:DDB_G0285599
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285599 mcfB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 141Mitochondrial intermembraneBy similarityAdd BLAST141
Transmembranei142 – 159Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini160 – 203Mitochondrial matrixBy similarityAdd BLAST44
Transmembranei204 – 224Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini225 – 244Mitochondrial intermembraneBy similarityAdd BLAST20
Transmembranei245 – 265Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini266 – 293Mitochondrial matrixBy similarityAdd BLAST28
Transmembranei294 – 314Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini315 – 338Mitochondrial intermembraneBy similarityAdd BLAST24
Transmembranei339 – 359Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini360 – 402Mitochondrial matrixBy similarityAdd BLAST43
Transmembranei403 – 423Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini424 – 434Mitochondrial intermembraneBy similarityAdd BLAST11

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003855181 – 434Mitochondrial substrate carrier family protein BAdd BLAST434

Proteomic databases

PaxDbiQ54MZ4

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0237602

Structurei

3D structure databases

ProteinModelPortaliQ54MZ4
SMRiQ54MZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 75EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini77 – 112EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Repeati136 – 229Solcar 1Add BLAST94
Repeati239 – 325Solcar 2Add BLAST87
Repeati333 – 422Solcar 3Add BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 28Poly-AsnAdd BLAST26
Compositional biasi31 – 35Poly-Asn5

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752 Eukaryota
ENOG410ZRF1 LUCA
InParanoidiQ54MZ4
KOiK14684
OMAiKMWREEG
PhylomeDBiQ54MZ4

Family and domain databases

CDDicd00051 EFh, 1 hit
Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q54MZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNNNNNNN NNNNNNNNNN NNNNNNNNDK NNNNNIDSSI KEKKLKEWFD
60 70 80 90 100
KFDVDKDGSL DSNELKKGFK LHANIDMKDE QITKMMERAD SNKNHRIEWD
110 120 130 140 150
EFLKVASDSS SPEIEDIAEH WLQYSTKPIV HAPADVPSWK LLLSGGVAGA
160 170 180 190 200
VSRTCTSPLE RLKILNQVGH MNLEQNAPKY KGRGIIQSLK TMYTTEGFIG
210 220 230 240 250
FFKGNGTNVI RIAPYSAIQF LSYEKYKNFL LNNNDQTHLT TYENLFVGGA
260 270 280 290 300
AGVTSLLCTY PLDLIRSRLT VQVFGNKYNG IADTCKMIIR EEGVAGLYKG
310 320 330 340 350
LFASALGVAP YVAINFTTYE NLKKTFIPKD TTPTVVQSLT FGAISGATAQ
360 370 380 390 400
TLTYPIDLIR RRLQVQGIGG KDILYNGTFD AFRKIIRDEG VLGLYNGMIP
410 420 430
CYLKVIPAIS ISFCVYEVMK KILKIDSKKI SYQS
Length:434
Mass (Da):48,684
Last modified:May 24, 2005 - v1
Checksum:i40E6C46F905314A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000079 Genomic DNA Translation: EAL64637.1
RefSeqiXP_638149.1, XM_633057.1

Genome annotation databases

EnsemblProtistsiEAL64637; EAL64637; DDB_G0285599
GeneIDi8625197
KEGGiddi:DDB_G0285599

Similar proteinsi

Entry informationi

Entry nameiMCFB_DICDI
AccessioniPrimary (citable) accession number: Q54MZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: May 24, 2005
Last modified: February 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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