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UniProtKB - Q54MH9 (RFC1_DICDI)

Entry version 111 (23 Feb 2022)
Sequence version 1 (24 May 2005)
Previous versions | rss
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Protein

Probable replication factor C subunit 1

Gene

rfc1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 1 binds to the primer-template junction (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi898 – 905ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processDNA replication, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DDI-5656169, Termination of translesion DNA synthesis
R-DDI-6782135, Dual incision in TC-NER
R-DDI-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DDI-69091, Polymerase switching

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable replication factor C subunit 1
Alternative name(s):
Activator 1 subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rfc1
ORF Names:DDB_G0285961
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...dictyBasei		DDB_G0285961, rfc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003304641 – 1401Probable replication factor C subunit 1Add BLAST1401

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q54MH9

PRoteomics IDEntifications database

More...PRIDEi		Q54MH9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heteropentamer of various rfc subunits that forms a complex (RFC) with PCNA in the presence of ATP.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		44689.DDB0232230

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q54MH9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini637 – 727BRCTPROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 639DisorderedSequence analysisAdd BLAST639
Regioni721 – 829DisorderedSequence analysisAdd BLAST109
Regioni1334 – 1401DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 30Polar residuesSequence analysisAdd BLAST20
Compositional biasi58 – 134Basic and acidic residuesSequence analysisAdd BLAST77
Compositional biasi136 – 151Polar residuesSequence analysisAdd BLAST16
Compositional biasi204 – 241Basic and acidic residuesSequence analysisAdd BLAST38
Compositional biasi242 – 257Polar residuesSequence analysisAdd BLAST16
Compositional biasi258 – 272Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi303 – 342Polar residuesSequence analysisAdd BLAST40
Compositional biasi360 – 393Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi394 – 426Polar residuesSequence analysisAdd BLAST33
Compositional biasi437 – 460Polar residuesSequence analysisAdd BLAST24
Compositional biasi461 – 480Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi481 – 495Polar residuesSequence analysisAdd BLAST15
Compositional biasi496 – 518Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi528 – 542Polar residuesSequence analysisAdd BLAST15
Compositional biasi543 – 560Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi576 – 614Polar residuesSequence analysisAdd BLAST39
Compositional biasi743 – 829Polar residuesSequence analysisAdd BLAST87
Compositional biasi1350 – 1366Acidic residuesSequence analysisAdd BLAST17
Compositional biasi1367 – 1390Basic and acidic residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the activator 1 large subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1968, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_254323_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q54MH9

Identification of Orthologs from Complete Genome Data

More...OMAi		RLYYVPM

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q54MH9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10190, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR008921, DNA_pol3_clamp-load_cplx_C
IPR013725, DNA_replication_fac_RFC1_C
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00004, AAA, 1 hit
PF00533, BRCT, 1 hit
PF08519, RFC1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit
SM00292, BRCT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48019, SSF48019, 1 hit
SSF52113, SSF52113, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50172, BRCT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54MH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKKANKEQS PKKTSPTSSQ GSTATKKKTK TSEPAGTDIR NFFAVIKPST 
        60         70         80         90        100
SGENVKNDLF SKAKEDSNKE FSLSDKENDD VKIISNKKDT TNNDKKKPSE 
       110        120        130        140        150
NKSPKKKEPS KSIDLTSDED KSSSEEDKKK PSSSSSKKKP SSSSSSLPNK 
       160        170        180        190        200
KKSTLKRLKK KRDDSSSSSS SSESDFDSGS DLDIESIDQK PKTITKKKNL 
       210        220        230        240        250
KRKSKPDSSS SSEDETKHQK DKKIKLKTPE KKIEEPEKKV EIPSSTSSIS 
       260        270        280        290        300
SSQKKIVYSF EDSEDSDADK PIPPSKKPSA VVVNAPSTKT FEKKKENTDI 
       310        320        330        340        350
PPSPSKTKET TSTTTDTKPI KSPSKSNKST TPTTTTPITT EKKKIAQLEF 
       360        370        380        390        400
ESPIVSITAI DTEKKKDGNK DNKNKEKDKD SSPFDEMEIE ESKSKTIMPN 
       410        420        430        440        450
NNNNNKSKES SSSTTNSKNN TSMNDDLIFD DFAFSPIKSG SNKTTPSKST 
       460        470        480        490        500
SSPSKETTPI KTRSKTVESK FDDDSIFDSP DKKTTTTTAS NTKTKTPPSK 
       510        520        530        540        550
KDKFNHDIIF EESDTPLNRA IEDSIVKRSL SGLNNIDKDS KTTTTTTTEK 
       560        570        580        590        600
KQKLKSDPFD TETEEETEDE GDEPLYKQQS SSFGSGSINP TATPTTPTKK 
       610        620        630        640        650
PAATSTNATP TKKPNPFMYM NGRPTPPNKG SKPRPQGKEN CLRGKVFLVS 
       660        670        680        690        700
GVMDCFERDE MHDIIKRWGG KVAKSAVKLL NYLVSGKDVG EKKLEGAKKV 
       710        720        730        740        750
GAKIITEDEF LEMINKTLPK PVSTTETTHI SLPTPTPTPT PTPASSSSSS 
       760        770        780        790        800
TTTTTTTTTT TTNSTGIKGP SLPVRSGSGG SSTGIKGPSL PVRSGSGGTT 
       810        820        830        840        850
SSSPPLTFTS SPPTSTTTAT TTTTSSPPIS MASVIVPKSI STIPKGHDIL 
       860        870        880        890        900
WVEKYRPKVI EDIVGNPGIF QEFGKWLDQW NSTAPRDASK KNAVLLSGPP 
       910        920        930        940        950
GIGKTSAALL ICKQKGFEAI ELNASDARSK SEIKRLLSGV SDNQNITKFF 
       960        970        980        990       1000
GTTNQDTGKD VQANKKIKTA IILDEIDGSS GNSDRGGIAE IIGLIKKSKM 
      1010       1020       1030       1040       1050
PFICLCNDYY SSKVTSLRNH CMDLKLRKPT LNQVSSRLLA IAKHEGMKVS 
      1060       1070       1080       1090       1100
SYMIEKVYTS SHSDIRQSIN TLQMMSRSKR DYNNDNVTQS LQEKDFDISP 
      1110       1120       1130       1140       1150
FTAAELILRE DNSNINKKLD YFFSDFSLVP LIIQENYLKT RPYGGGSQSK 
      1160       1170       1180       1190       1200
YNDCELISMA ADALSDSDQF GRAIGKEMAW NLLPTYGVTS CIIPSGYIRG 
      1210       1220       1230       1240       1250
SPPMPLSFPS YLGKYSNASK QQRFVRELQL HMRSTSNTFV NRDETRLYYV 
      1260       1270       1280       1290       1300
PMLKHHLIQP LVQDDNDGIE NVINVMDEYG LTEDDRNNII ELSTWGKEDP 
      1310       1320       1330       1340       1350
LKDVKTQVKS AFTRKFRSTS HAIYDVSLLS SKGSGGGGTN IAEGYEEVEG 
      1360       1370       1380       1390       1400
ESQNQIEEED EETEEKDSLP NLVKKSSVKS KSDTKPKSTK SKSTTTKSKK 

K
Length:1,401
Mass (Da):153,582
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F4328D06524FFD9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAFI02000082 Genomic DNA Translation: EAL64515.1

NCBI Reference Sequences

More...RefSeqi		XP_638011.1, XM_632919.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		EAL64515; EAL64515; DDB_G0285961

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8625362

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ddi:DDB_G0285961

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000082 Genomic DNA Translation: EAL64515.1
RefSeqiXP_638011.1, XM_632919.1

3D structure databases

SMRiQ54MH9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232230

Proteomic databases

PaxDbiQ54MH9
PRIDEiQ54MH9

Genome annotation databases

EnsemblProtistsiEAL64515; EAL64515; DDB_G0285961
GeneIDi8625362
KEGGiddi:DDB_G0285961

Organism-specific databases

dictyBaseiDDB_G0285961, rfc1

Phylogenomic databases

eggNOGiKOG1968, Eukaryota
HOGENOMiCLU_254323_0_0_1
InParanoidiQ54MH9
OMAiRLYYVPM
PhylomeDBiQ54MH9

Enzyme and pathway databases

ReactomeiR-DDI-5656169, Termination of translesion DNA synthesis
R-DDI-6782135, Dual incision in TC-NER
R-DDI-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DDI-69091, Polymerase switching

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q54MH9

Family and domain databases

Gene3Di3.40.50.10190, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR008921, DNA_pol3_clamp-load_cplx_C
IPR013725, DNA_replication_fac_RFC1_C
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF00533, BRCT, 1 hit
PF08519, RFC1, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00292, BRCT, 1 hit
SUPFAMiSSF48019, SSF48019, 1 hit
SSF52113, SSF52113, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50172, BRCT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRFC1_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54MH9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: February 23, 2022
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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