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Entry version 111 (23 Feb 2022)
Sequence version 1 (24 May 2005)
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Protein

Probable replication factor C subunit 1

Gene

rfc1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 1 binds to the primer-template junction (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi898 – 905ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processDNA replication, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-5656169, Termination of translesion DNA synthesis
R-DDI-6782135, Dual incision in TC-NER
R-DDI-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DDI-69091, Polymerase switching

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable replication factor C subunit 1
Alternative name(s):
Activator 1 subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rfc1
ORF Names:DDB_G0285961
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0285961, rfc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003304641 – 1401Probable replication factor C subunit 1Add BLAST1401

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54MH9

PRoteomics IDEntifications database

More...
PRIDEi
Q54MH9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heteropentamer of various rfc subunits that forms a complex (RFC) with PCNA in the presence of ATP.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0232230

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54MH9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini637 – 727BRCTPROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 639DisorderedSequence analysisAdd BLAST639
Regioni721 – 829DisorderedSequence analysisAdd BLAST109
Regioni1334 – 1401DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 30Polar residuesSequence analysisAdd BLAST20
Compositional biasi58 – 134Basic and acidic residuesSequence analysisAdd BLAST77
Compositional biasi136 – 151Polar residuesSequence analysisAdd BLAST16
Compositional biasi204 – 241Basic and acidic residuesSequence analysisAdd BLAST38
Compositional biasi242 – 257Polar residuesSequence analysisAdd BLAST16
Compositional biasi258 – 272Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi303 – 342Polar residuesSequence analysisAdd BLAST40
Compositional biasi360 – 393Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi394 – 426Polar residuesSequence analysisAdd BLAST33
Compositional biasi437 – 460Polar residuesSequence analysisAdd BLAST24
Compositional biasi461 – 480Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi481 – 495Polar residuesSequence analysisAdd BLAST15
Compositional biasi496 – 518Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi528 – 542Polar residuesSequence analysisAdd BLAST15
Compositional biasi543 – 560Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi576 – 614Polar residuesSequence analysisAdd BLAST39
Compositional biasi743 – 829Polar residuesSequence analysisAdd BLAST87
Compositional biasi1350 – 1366Acidic residuesSequence analysisAdd BLAST17
Compositional biasi1367 – 1390Basic and acidic residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the activator 1 large subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1968, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_254323_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54MH9

Identification of Orthologs from Complete Genome Data

More...
OMAi
RLYYVPM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54MH9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10190, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR008921, DNA_pol3_clamp-load_cplx_C
IPR013725, DNA_replication_fac_RFC1_C
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004, AAA, 1 hit
PF00533, BRCT, 1 hit
PF08519, RFC1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit
SM00292, BRCT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48019, SSF48019, 1 hit
SSF52113, SSF52113, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172, BRCT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54MH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKKANKEQS PKKTSPTSSQ GSTATKKKTK TSEPAGTDIR NFFAVIKPST
60 70 80 90 100
SGENVKNDLF SKAKEDSNKE FSLSDKENDD VKIISNKKDT TNNDKKKPSE
110 120 130 140 150
NKSPKKKEPS KSIDLTSDED KSSSEEDKKK PSSSSSKKKP SSSSSSLPNK
160 170 180 190 200
KKSTLKRLKK KRDDSSSSSS SSESDFDSGS DLDIESIDQK PKTITKKKNL
210 220 230 240 250
KRKSKPDSSS SSEDETKHQK DKKIKLKTPE KKIEEPEKKV EIPSSTSSIS
260 270 280 290 300
SSQKKIVYSF EDSEDSDADK PIPPSKKPSA VVVNAPSTKT FEKKKENTDI
310 320 330 340 350
PPSPSKTKET TSTTTDTKPI KSPSKSNKST TPTTTTPITT EKKKIAQLEF
360 370 380 390 400
ESPIVSITAI DTEKKKDGNK DNKNKEKDKD SSPFDEMEIE ESKSKTIMPN
410 420 430 440 450
NNNNNKSKES SSSTTNSKNN TSMNDDLIFD DFAFSPIKSG SNKTTPSKST
460 470 480 490 500
SSPSKETTPI KTRSKTVESK FDDDSIFDSP DKKTTTTTAS NTKTKTPPSK
510 520 530 540 550
KDKFNHDIIF EESDTPLNRA IEDSIVKRSL SGLNNIDKDS KTTTTTTTEK
560 570 580 590 600
KQKLKSDPFD TETEEETEDE GDEPLYKQQS SSFGSGSINP TATPTTPTKK
610 620 630 640 650
PAATSTNATP TKKPNPFMYM NGRPTPPNKG SKPRPQGKEN CLRGKVFLVS
660 670 680 690 700
GVMDCFERDE MHDIIKRWGG KVAKSAVKLL NYLVSGKDVG EKKLEGAKKV
710 720 730 740 750
GAKIITEDEF LEMINKTLPK PVSTTETTHI SLPTPTPTPT PTPASSSSSS
760 770 780 790 800
TTTTTTTTTT TTNSTGIKGP SLPVRSGSGG SSTGIKGPSL PVRSGSGGTT
810 820 830 840 850
SSSPPLTFTS SPPTSTTTAT TTTTSSPPIS MASVIVPKSI STIPKGHDIL
860 870 880 890 900
WVEKYRPKVI EDIVGNPGIF QEFGKWLDQW NSTAPRDASK KNAVLLSGPP
910 920 930 940 950
GIGKTSAALL ICKQKGFEAI ELNASDARSK SEIKRLLSGV SDNQNITKFF
960 970 980 990 1000
GTTNQDTGKD VQANKKIKTA IILDEIDGSS GNSDRGGIAE IIGLIKKSKM
1010 1020 1030 1040 1050
PFICLCNDYY SSKVTSLRNH CMDLKLRKPT LNQVSSRLLA IAKHEGMKVS
1060 1070 1080 1090 1100
SYMIEKVYTS SHSDIRQSIN TLQMMSRSKR DYNNDNVTQS LQEKDFDISP
1110 1120 1130 1140 1150
FTAAELILRE DNSNINKKLD YFFSDFSLVP LIIQENYLKT RPYGGGSQSK
1160 1170 1180 1190 1200
YNDCELISMA ADALSDSDQF GRAIGKEMAW NLLPTYGVTS CIIPSGYIRG
1210 1220 1230 1240 1250
SPPMPLSFPS YLGKYSNASK QQRFVRELQL HMRSTSNTFV NRDETRLYYV
1260 1270 1280 1290 1300
PMLKHHLIQP LVQDDNDGIE NVINVMDEYG LTEDDRNNII ELSTWGKEDP
1310 1320 1330 1340 1350
LKDVKTQVKS AFTRKFRSTS HAIYDVSLLS SKGSGGGGTN IAEGYEEVEG
1360 1370 1380 1390 1400
ESQNQIEEED EETEEKDSLP NLVKKSSVKS KSDTKPKSTK SKSTTTKSKK

K
Length:1,401
Mass (Da):153,582
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F4328D06524FFD9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000082 Genomic DNA Translation: EAL64515.1

NCBI Reference Sequences

More...
RefSeqi
XP_638011.1, XM_632919.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL64515; EAL64515; DDB_G0285961

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8625362

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0285961

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000082 Genomic DNA Translation: EAL64515.1
RefSeqiXP_638011.1, XM_632919.1

3D structure databases

SMRiQ54MH9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232230

Proteomic databases

PaxDbiQ54MH9
PRIDEiQ54MH9

Genome annotation databases

EnsemblProtistsiEAL64515; EAL64515; DDB_G0285961
GeneIDi8625362
KEGGiddi:DDB_G0285961

Organism-specific databases

dictyBaseiDDB_G0285961, rfc1

Phylogenomic databases

eggNOGiKOG1968, Eukaryota
HOGENOMiCLU_254323_0_0_1
InParanoidiQ54MH9
OMAiRLYYVPM
PhylomeDBiQ54MH9

Enzyme and pathway databases

ReactomeiR-DDI-5656169, Termination of translesion DNA synthesis
R-DDI-6782135, Dual incision in TC-NER
R-DDI-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DDI-69091, Polymerase switching

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54MH9

Family and domain databases

Gene3Di3.40.50.10190, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR008921, DNA_pol3_clamp-load_cplx_C
IPR013725, DNA_replication_fac_RFC1_C
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF00533, BRCT, 1 hit
PF08519, RFC1, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00292, BRCT, 1 hit
SUPFAMiSSF48019, SSF48019, 1 hit
SSF52113, SSF52113, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50172, BRCT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRFC1_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54MH9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: February 23, 2022
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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