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Entry version 98 (02 Jun 2021)
Sequence version 1 (24 May 2005)
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Protein

ATP-dependent DNA helicase ku70

Gene

ku70

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in non-homologous end joining (NHEJ) DNA double strand break repair.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-5693571, Nonhomologous End-Joining (NHEJ)
R-DDI-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent DNA helicase ku70 (EC:3.6.4.12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ku70
ORF Names:DDB_G0286069
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0286069, ku70

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003768711 – 909ATP-dependent DNA helicase ku70Add BLAST909

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54MA9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of ku70 and ku80.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0232001

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini321 – 587KuAdd BLAST267
Domaini697 – 733SAPAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni494 – 548DisorderedSequence analysisAdd BLAST55
Regioni663 – 685DisorderedSequence analysisAdd BLAST23
Regioni744 – 859DisorderedSequence analysisAdd BLAST116

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi494 – 547Polar residuesSequence analysisAdd BLAST54
Compositional biasi774 – 798Polar residuesSequence analysisAdd BLAST25
Compositional biasi812 – 830Polar residuesSequence analysisAdd BLAST19

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2327, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014815_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54MA9

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNDMMGI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54MA9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.290.10, 1 hit
3.40.50.410, 1 hit
4.10.970.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019406, APLF_PBZ
IPR006165, Ku70
IPR006164, Ku70/Ku80_beta-barrel_dom
IPR027388, Ku70_bridge/pillars_dom_sf
IPR005160, Ku_C
IPR005161, Ku_N
IPR016194, SPOC-like_C_dom_sf
IPR036465, vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12604:SF2, PTHR12604:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02735, Ku, 1 hit
PF03730, Ku_C, 1 hit
PF03731, Ku_N, 1 hit
PF10283, zf-CCHH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00559, Ku78, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100939, SSF100939, 1 hit
SSF53300, SSF53300, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00578, ku70, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54MA9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTNSWLNN NNNNSNTTLT NTNTIGGTNF GINQFDGDDW DNIFDGNNGD
60 70 80 90 100
GDGDLDGDSY KSYQNPYSYR DCIIFLIDAS KAMFEPNENN EIPFHNAVKC
110 120 130 140 150
LIQTITDKII TSDSDLIGVC FYNTNKKKNI NDFENIYVLS DLDIPDPKII
160 170 180 190 200
LTLEEMLENS NFTTNGLGNC QGEMPFCDAL WTCSTMFSNI KQSGSSSGEN
210 220 230 240 250
SNNNNFKRIF LFTNEDNPNA YNDSIRNSSI QRSKDLSDLN IQIELFSMNK
260 270 280 290 300
SVNDKFDFSL FYQHILIFAD EENYLDPTQF DASSKFSDLR FKLKRKEFKK
310 320 330 340 350
RSLGKLPLYI GNLNNNNNNS NSLDSQVIIS TQLYNLFSHA HKSSPTLLDP
360 370 380 390 400
KTNLPVKQLI KNVCANTQAT LLPSQIKLCY HYGGEPVIFT KDEMQTIKSI
410 420 430 440 450
DRIGFTLLGF KPLENIKPYH SIKHSQFIFP DDQSIKGSVL AFNALVEQML
460 470 480 490 500
KSGKAAICRF TPRSSSSPRM VALIPQEEIL QSESEFNNQQ LLNSLSSQQQ
510 520 530 540 550
QQQSSQQSSS SQQQQQQQQQ QQQQQQQQQQ QQLPSSSQQS NNNRKIQIRP
560 570 580 590 600
RGMHVIYLPF ADDIRYPNNI GVKSDGLEIK QENIDKAKNI IKMMKIKFDE
610 620 630 640 650
KKFVNPGLQK HYASLQAIAL ERDKVEETVD NIQPDRKLIE KVIDTTQDFS
660 670 680 690 700
DGIFPVGYAS TVSSATSSTS SSSAKRLRDG KDLSTMDWPD MVKSGEIIKL
710 720 730 740 750
TVDDLKSFLS NQNIKPSSKA KKADLIDLIS NLISGGNFKP DKLHLLKKDS
760 770 780 790 800
PPLSDNTITT NGGDDDDNNR PSKKVKSTST STTASKNTSS SSPPLVSAAT
810 820 830 840 850
MNKKAPPKKS FSVKDKNSSN NSSGGSSKAN VNDEFDIDFK NSDQDDDTDN
860 870 880 890 900
ESDVNNKATT STTTITTTTA APKKNNFVNN GMFDTRELCK YGKNCYRTNK

QHLDEYRHQ
Length:909
Mass (Da):102,003
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i143DF762FC65BDF2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000085 Genomic DNA Translation: EAL64413.1

NCBI Reference Sequences

More...
RefSeqi
XP_637925.1, XM_632833.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL64413; EAL64413; DDB_G0286069

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8625436

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0286069

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000085 Genomic DNA Translation: EAL64413.1
RefSeqiXP_637925.1, XM_632833.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0232001

Proteomic databases

PaxDbiQ54MA9

Genome annotation databases

EnsemblProtistsiEAL64413; EAL64413; DDB_G0286069
GeneIDi8625436
KEGGiddi:DDB_G0286069

Organism-specific databases

dictyBaseiDDB_G0286069, ku70

Phylogenomic databases

eggNOGiKOG2327, Eukaryota
HOGENOMiCLU_014815_2_0_1
InParanoidiQ54MA9
OMAiPNDMMGI
PhylomeDBiQ54MA9

Enzyme and pathway databases

ReactomeiR-DDI-5693571, Nonhomologous End-Joining (NHEJ)
R-DDI-6798695, Neutrophil degranulation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54MA9

Family and domain databases

Gene3Di2.40.290.10, 1 hit
3.40.50.410, 1 hit
4.10.970.10, 1 hit
InterProiView protein in InterPro
IPR019406, APLF_PBZ
IPR006165, Ku70
IPR006164, Ku70/Ku80_beta-barrel_dom
IPR027388, Ku70_bridge/pillars_dom_sf
IPR005160, Ku_C
IPR005161, Ku_N
IPR016194, SPOC-like_C_dom_sf
IPR036465, vWFA_dom_sf
PANTHERiPTHR12604:SF2, PTHR12604:SF2, 1 hit
PfamiView protein in Pfam
PF02735, Ku, 1 hit
PF03730, Ku_C, 1 hit
PF03731, Ku_N, 1 hit
PF10283, zf-CCHH, 1 hit
SMARTiView protein in SMART
SM00559, Ku78, 1 hit
SUPFAMiSSF100939, SSF100939, 1 hit
SSF53300, SSF53300, 1 hit
TIGRFAMsiTIGR00578, ku70, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKU70_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54MA9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 24, 2005
Last modified: June 2, 2021
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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