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UniProtKB - Q54LH5 (INT4_DICDI)

Entry version 83 (02 Dec 2020)
Sequence version 1 (24 May 2005)
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Protein

Integrator complex subunit 4 homolog

Gene

ints4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • snRNA processing Source: GO_Central
Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrator complex subunit 4 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ints4
ORF Names:DDB_G0286633
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...dictyBasei		DDB_G0286633, ints4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003443761 – 1233Integrator complex subunit 4 homologAdd BLAST1233

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q54LH5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		44689.DDB0234080

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati236 – 273HEAT 1Add BLAST38
Repeati275 – 310HEAT 2Add BLAST36
Repeati487 – 524HEAT 3Add BLAST38
Repeati525 – 561HEAT 4Add BLAST37
Repeati563 – 597HEAT 5Add BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 25Poly-GlnAdd BLAST14
Compositional biasi28 – 94Poly-GlnAdd BLAST67
Compositional biasi428 – 444Poly-GlnAdd BLAST17
Compositional biasi723 – 733Poly-AsnAdd BLAST11
Compositional biasi766 – 792Poly-AsnAdd BLAST27
Compositional biasi979 – 987Poly-Asn9
Compositional biasi1054 – 1064Poly-ThrAdd BLAST11
Compositional biasi1200 – 1206Poly-Asn7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Integrator subunit 4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2259, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_267504_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q54LH5

Identification of Orthologs from Complete Genome Data

More...OMAi		NCACKLL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54LH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKKSHQQQV LQQQQQQQQQ QFQQQHFQQQ QQQQQFQQQQ QQQQQLQQQQ 
        60         70         80         90        100
LQQQQQQQIQ QQQQIQQQQQ QQQQQQQQIQ QQQQPQQIQQ PQQQLPNFSV 
       110        120        130        140        150
PIINQSIISN IKLYSTFETL LLSLSSTDTR EQTKAIIYLS SLTINNKSNG 
       160        170        180        190        200
IDLVYCIQKQ LVVEAHNHIK VLLINLLGDI SLDPFIDSFH ILNKLLYLIR 
       210        220        230        240        250
NEKSKKVLSS CLININKISK SLTFSKGNDV NSSSSSLINQ IIEYIEPLLH 
       260        270        280        290        300
STSPLVRRET IVLLGSIVKN LDKESEEIQI LLLNYLKDTD FRVREASLKS 
       310        320        330        340        350
LSVIFQRGAS LSVNKLYQSI ILLLLDSFEQ VRLECIKLIW IFGNIYPNHI 
       360        370        380        390        400
VVSGGTKIRL VDDVFKKICN AVNDSSVIVR NCACKLLGCT YDVSLNYLIQ 
       410        420        430        440        450
TLSKEVMVWG KGKQYQIGHS SITKQRLQQK QQQQQQQQQQ QQQQPPQQQP 
       460        470        480        490        500
SQQPNQQPNQ QQTNVSGTHI ATPEGDFDVV GSDSLNILES GVIGAFIQGL 
       510        520        530        540        550
EDEFYEVRSS AIDSMCELSV RNDEFAQKNI DFLVDIFNDE IESVRINSIN 
       560        570        580        590        600
SLRKIGNNVV IKEEQLHIIL ANLESSSKEE RQSLHRLLTS IHLSNYSCLH 
       610        620        630        640        650
ATTQALLMNL SRYPYDIHSI FETLKIIGQT NPFTEFIVDD LLRIDPKFAS 
       660        670        680        690        700
VEPNMDDIFY VAVMVLVLNS CIKNRNILSL LPSFSFQHHL YFKDKYPKYF 
       710        720        730        740        750
PQNLQKDSNI ILAPTLKYSS VVNNNNNKNN NNNTTTTSII NDNGEINQFL 
       760        770        780        790        800
NLTLSLLYGD NNNIINNNNT NNNNNNNNNN NNNNNNNNNN NNDENDENLN 
       810        820        830        840        850
YGFQRLFLNQ KKEIQLNKLF QECKRNFKRI SSICLSLKPT SDFYNKYLKI 
       860        870        880        890        900
LTTIVSSSRR FKTITTSNQL NHLLYKLNHK FIGVDNNCKL ILMEIGIYSF 
       910        920        930        940        950
IIEILSTITL STSSPPTTTT TTSSTSLFTS INSTPIELSN DQINQLTKKL 
       960        970        980        990       1000
NEYFKFSNDF KLEISTSIKS LLDLFNIKNN NINNNNNIIN KKDKKLKENE 
      1010       1020       1030       1040       1050
ENEENEENEN NENENEKENG KNKEKEKNEN DNENENENER PSKIQKTTSE 
      1060       1070       1080       1090       1100
LIKTTTTTST STSTLIHYNL IEWTDNYIPP ILKISNLIKK KSVDVILPIP 
      1110       1120       1130       1140       1150
NDKPIEFLDI FPLKLMINAK IENIRNLDSL FIQSTWQSIH TGQLNSQIHI 
      1160       1170       1180       1190       1200
IPKSAFTPTK PLSYNISCSI YLSLQNIRHN RLSSKESIPL RISIVEQFLN 
      1210       1220       1230 
NNNNNNVTII PLSKFVIFNI LPVDNVNLLP NLI
Length:1,233
Mass (Da):141,988
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i330219236A04458A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAFI02000089 Genomic DNA Translation: EAL64072.1

NCBI Reference Sequences

More...RefSeqi		XP_637586.1, XM_632494.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		EAL64072; EAL64072; DDB_G0286633

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8625726

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ddi:DDB_G0286633

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000089 Genomic DNA Translation: EAL64072.1
RefSeqiXP_637586.1, XM_632494.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0234080

Proteomic databases

PaxDbiQ54LH5

Genome annotation databases

EnsemblProtistsiEAL64072; EAL64072; DDB_G0286633
GeneIDi8625726
KEGGiddi:DDB_G0286633

Organism-specific databases

dictyBaseiDDB_G0286633, ints4

Phylogenomic databases

eggNOGiKOG2259, Eukaryota
HOGENOMiCLU_267504_0_0_1
InParanoidiQ54LH5
OMAiNCACKLL

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q54LH5

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINT4_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54LH5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 24, 2005
Last modified: December 2, 2020
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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