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UniProtKB - Q54KU5 (PKS24_DICDI)
Protein
Probable polyketide synthase 24
Gene
pks24
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes and clustered as a pair pks24/pks25 in chromosome 4.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 190 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 664 | For acyl/malonyl transferase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- oxidoreductase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pks24 ORF Names:DDB_G0287119 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0287119, pks24 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000367830 | 1 – 2471 | Probable polyketide synthase 24Add BLAST | 2471 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2373 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | Q54KU5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2336 – 2413 | CarrierPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 171 – 224 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 654 – 687 | Acyl/malonyl transferaseAdd BLAST | 34 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1426 – 1469 | Sequence analysisAdd BLAST | 44 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | Q54KU5 |
PhylomeDBi | Q54KU5 |
Family and domain databases
Gene3Di | 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54KU5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKQNKINKAE ILQVDDKHVE ENLVAIVGVG FRLPSGSIEN ERNNTPQTLW
60 70 80 90 100
NNLINGFDGV VKTSERFNDN FFKNHEIANN YSGLLPLDEV KSFDPLFFGI
110 120 130 140 150
NPNEAPTIDP IQRLLLKCTW EALEDSLIDP ISIKGTDTSV FIGCTESDYH
160 170 180 190 200
NINKNEVKSN VFSSLNHAIS NRISYCYDLH GNSITLDTAC SSSLNAIALG
210 220 230 240 250
YDSIKNKKSK MSIVGGVNIL LDSYFFKAYS SLNILSKSNG RCKSFDASAD
260 270 280 290 300
GYVRSECIGV VVLKNLKDAI KDGNRIYCTI NGASANVDGI GYSDKSNFYS
310 320 330 340 350
PSSISQSENL KNAIQSTNGT VKPSDIDYVE AHGTGTPTGD PIEVEGISKV
360 370 380 390 400
FKDTRSTDTP LLIGSFKSNI GHCEAASGIA SLIKCCLMYK NKCFAPNIHF
410 420 430 440 450
KTPNPAIKFK EWNLKVVTEP IPFNKFKNTS MVVNNFGATG SNCCLVLSQF
460 470 480 490 500
NYNTINNNIN NHNNNHNHNH NHNNIKINNY LIPFSANSVE SLKKYQSLII
510 520 530 540 550
ENKEYESQYS FEEFVKNQIY NKSTSLYQRS VIVAKDWNDF NNVENQVKYQ
560 570 580 590 600
TSSSTSSNIT ITNKNNNPIT VFVFCGQGSQ YNTMALELYK NEKVFRNSMD
610 620 630 640 650
MLDNKMKNYF GYSILEKLRA IQDSDKCSVH EQTMAQPSTV IIQVSLYELY
660 670 680 690 700
KHWGIKASFM LGHSLGEVTT AYCSGMIDID QLCYLIYHRS TLQIRTNGSG
710 720 730 740 750
KMLSINISSD EYKTNYMSRY PTIEIACYNS PSSIVIAGNE QILNEISKEL
760 770 780 790 800
KEKEIFSAML GSLSSFHTSS QNIIKDDILN LNIQSSQPVI PTFSTVTSNL
810 820 830 840 850
FNESTIFDSE YFFDNISKPV SFTQTISNLY KHIEDNQIGS NIVFIEIAPH
860 870 880 890 900
PTLSFYLKQM IPKQSQYFRN GESISVYSTL HKKKNDVEEF QKSISQLFCD
910 920 930 940 950
DAYDINFKCQ FNNINSNIEA ISNFNLPLYQ WDDQHYWLNK SIEHKNNLIG
960 970 980 990 1000
PPISILGNSM QDSNPFIKSY QTIIDTGKDA FKYLKGHNVS DKCYFPGTGY
1010 1020 1030 1040 1050
IDNIFKLYPN QDLTINSIEF KVPFVLTDGI GQCLQTNVYQ TGKSEYRAQF
1060 1070 1080 1090 1100
HLKDEMNNQW INTSNSNFHL NSNDNYHEEK QKLDIQDIKQ TKCNLSSIPW
1110 1120 1130 1140 1150
DEFYSLMKTQ LGANFYGIFS KVVECYIGDN CSLTEISLEL PENFHDEQSF
1160 1170 1180 1190 1200
FNCPLIDACF HGTVILYIQK NCKIVTDKVE GLRYYASNIP KNRDEHSSIF
1210 1220 1230 1240 1250
IYSTLKSSPS DDLLSSSIVV MLEDGTVIIE VDNLVVKSLT PVKDPLLIET
1260 1270 1280 1290 1300
PSDFIYTPYL QSKDSQIQSP LEFKSIYQNN QVDDGLLIPN VVIETIKPLI
1310 1320 1330 1340 1350
NRKMEFRILE FGGNNLSKST LLLNEINSLL EENPHYEIDI EYTWSDNNSS
1360 1370 1380 1390 1400
ILKDAKLELS KVDKGYLSIL YRSLGLDVDN SLLEKQKLNP SYYDLIIVSN
1410 1420 1430 1440 1450
ISNLTKDIEY SLNQIYQILT PNGYLIINEQ QQQQQQQQQQ QQQQQQQQQQ
1460 1470 1480 1490 1500
LLNNENNKES LKNLLVNCNF NSDIMIKSSS ISDSDIKSII IQAQKPSLKL
1510 1520 1530 1540 1550
QPKTINTFDQ VILYCYQDEQ LQQQQLINKF ENHYNNCKII KVSTIEEFYK
1560 1570 1580 1590 1600
LSTTITNNSI IYFIKSIEQL TLENFKSVTF EYVQINQKLY ELKSKCTHVL
1610 1620 1630 1640 1650
ITCDSQSSNY LSSSVLGAAR YFDEIPTLQL FTLDFDKDSL TNDLDLFKTI
1660 1670 1680 1690 1700
DYLINPKNNI QREFYIKNSG TVYFEMYKKE LKNLKNSYKS ESYHDLSKQQ
1710 1720 1730 1740 1750
DQLVSKLDEH FEYQLNSKQI DLEPYEIEVK VKATGINYKD YLKYNEMIKV
1760 1770 1780 1790 1800
NEAGIGFDFS GVVSRVGIKS SKEFKVGDQV YGIAYETSSS HIIIDSLLAC
1810 1820 1830 1840 1850
HKPSKITHVQ AASIPAVYST SLYCLYDVGN LRDEESVLIH SGSGGVGLSG
1860 1870 1880 1890 1900
LEILKSNNHS SPIFVTVGSE EKKQYLINTY GDLITGIYST RDTNYQKQIK
1910 1920 1930 1940 1950
NKLIELGYET HGVDLIINTL SSEFMDTNFK CLNPKGRIVD LTTTHLNPNE
1960 1970 1980 1990 2000
FIDNSRYRYN IGYNSIEILK VGKSTIKKLL QSISKSIENE TLNALIPITE
2010 2020 2030 2040 2050
FSNSNIKKSI ESIKERKHVG KIVISHDTDI IDKLIEKESM IDYSILKSDY
2060 2070 2080 2090 2100
KIKNLGKNVL VTGQTGLILE VLKWITKYNS TVENIIILSK SSLKWELEFL
2110 2120 2130 2140 2150
MNYNNNNNNN NNNNKIKYHF KKCDISNWNL INKTIDQVLK DNPTITNIDS
2160 2170 2180 2190 2200
IFHFAALQIN KKLKDIDMNS LNVSHSAKTF GAVNLHNLSI KRDWKIINFI
2210 2220 2230 2240 2250
LASSVVSVLG SFDQCSYVSA CCVVDSLSQY RKSIGLPSFT INIGGVSDRG
2260 2270 2280 2290 2300
YLSRHKLVEA VLGGQGVELI SPNQLLGTLD LQIQNPNMPT NAFVNNFNWP
2310 2320 2330 2340 2350
LFKSFKQKLH QKFDFILNPI NVDNSISMEN DTNQSSSSTN VKNKFLNKVS
2360 2370 2380 2390 2400
ELLSIDPSKI NTNIKMINYG ADSLITVQLK NWVDKEWSPH LITIQQIQSN
2410 2420 2430 2440 2450
SIGMVYQIIN DSLDKKKKEM DEKLLPITAK TTTTTKNDPN DKTEYKYIAG
2460 2470
GDCCREFSIK FHYSSVVNFI I
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000096 Genomic DNA Translation: EAL63924.1 |
RefSeqi | XP_637425.1, XM_632333.1 |
Genome annotation databases
EnsemblProtistsi | EAL63924; EAL63924; DDB_G0287119 |
GeneIDi | 8625958 |
KEGGi | ddi:DDB_G0287119 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000096 Genomic DNA Translation: EAL63924.1 |
RefSeqi | XP_637425.1, XM_632333.1 |
3D structure databases
SMRi | Q54KU5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0230081 |
Proteomic databases
PaxDbi | Q54KU5 |
Genome annotation databases
EnsemblProtistsi | EAL63924; EAL63924; DDB_G0287119 |
GeneIDi | 8625958 |
KEGGi | ddi:DDB_G0287119 |
Organism-specific databases
dictyBasei | DDB_G0287119, pks24 |
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | Q54KU5 |
PhylomeDBi | Q54KU5 |
Miscellaneous databases
PROi | PR:Q54KU5 |
Family and domain databases
Gene3Di | 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS24_DICDI | |
Accessioni | Q54KU5Primary (citable) accession number: Q54KU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 24, 2009 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase