Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable lysosomal cobalamin transporter

Gene

lmbrd1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandCobalamin, Cobalt

Enzyme and pathway databases

ReactomeiR-DDI-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lysosomal cobalamin transporter
Alternative name(s):
LMBR1 domain-containing protein 1 homolog
Gene namesi
Name:lmbrd1
ORF Names:DDB_G0287405
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287405

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 40ExtracellularSequence analysisAdd BLAST19
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Topological domaini62 – 88CytoplasmicSequence analysisAdd BLAST27
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 129ExtracellularSequence analysisAdd BLAST20
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 178CytoplasmicSequence analysisAdd BLAST28
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 289ExtracellularSequence analysisAdd BLAST90
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 345CytoplasmicSequence analysisAdd BLAST35
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 395ExtracellularSequence analysisAdd BLAST29
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 465CytoplasmicSequence analysisAdd BLAST49
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 510ExtracellularSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003285371 – 510Probable lysosomal cobalamin transporterAdd BLAST510

Proteomic databases

PaxDbiQ54KD1

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0235221

Family & Domainsi

Sequence similaritiesi

Belongs to the LIMR family. LMBRD1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFHV Eukaryota
ENOG410XPKG LUCA
InParanoidiQ54KD1
KOiK14617
OMAiRPLKIIW
PhylomeDBiQ54KD1

Family and domain databases

InterProiView protein in InterPro
IPR006876 LMBR1-like_membr_prot
PfamiView protein in Pfam
PF04791 LMBR1, 1 hit

Sequencei

Sequence statusi: Complete.

Q54KD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPISVGWIA FAGVLLTLIA LNYFIVKYYS DKHESGKITT IISVIGLTLT
60 70 80 90 100
LLCVMLIPVD ILNVSTMSHS DGTQISPYSI SQRTEGVKML YYILYGSILG
110 120 130 140 150
VSLILVPFAY FYHEEYDENI PTCSRVYAGC KFTIFFILFT IILLVVGAFV
160 170 180 190 200
RPGSKPIDDQ NVKDWINDEV LNQNAIESSV LFAISCLTVL GFLVFAVYTS
210 220 230 240 250
YGLSAFPIGL IKGKKRTDDD KSDINKDLWK AKEKSSFYSS KYASGKSLSE
260 270 280 290 300
KEQSTLSLLR GKERALSKRS ERLDNSNKGF RKILVIFRPF AFIFGFIFIL
310 320 330 340 350
VSLLIIISIV LSLVDKISSS VCGSACGFLS TYPQLKNPFD IILTKLAPYF
360 370 380 390 400
PLDYIIIGGL IFFIYSCTLS GITRIGIRFL WINMFEFGYR KTFPQGLLLA
410 420 430 440 450
SVLLMLSNLC LNMQIVNLAP RYVMYGAQVY LNGTSVIPCT INAPTDLCIM
460 470 480 490 500
SEIGLLTSRI QLGISFFGIV FYYGTWVIVA TFILGLAVSI FKRRPSAALS
510
YSGDSDEEEI
Length:510
Mass (Da):56,931
Last modified:May 24, 2005 - v1
Checksum:iD4C597894DAC3C25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000100 Genomic DNA Translation: EAL63770.1
RefSeqiXP_637292.1, XM_632200.1

Genome annotation databases

EnsemblProtistsiEAL63770; EAL63770; DDB_G0287405
GeneIDi8626124
KEGGiddi:DDB_G0287405

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000100 Genomic DNA Translation: EAL63770.1
RefSeqiXP_637292.1, XM_632200.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0235221

Proteomic databases

PaxDbiQ54KD1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL63770; EAL63770; DDB_G0287405
GeneIDi8626124
KEGGiddi:DDB_G0287405

Organism-specific databases

dictyBaseiDDB_G0287405

Phylogenomic databases

eggNOGiENOG410IFHV Eukaryota
ENOG410XPKG LUCA
InParanoidiQ54KD1
KOiK14617
OMAiRPLKIIW
PhylomeDBiQ54KD1

Enzyme and pathway databases

ReactomeiR-DDI-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Miscellaneous databases

PROiPR:Q54KD1

Family and domain databases

InterProiView protein in InterPro
IPR006876 LMBR1-like_membr_prot
PfamiView protein in Pfam
PF04791 LMBR1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLMBD1_DICDI
AccessioniPrimary (citable) accession number: Q54KD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: February 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again