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Entry version 114 (23 Feb 2022)
Sequence version 1 (24 May 2005)
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Protein

Ankyrin repeat, PH and SEC7 domain containing protein secG

Gene

secG

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat, PH and SEC7 domain containing protein secG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:secG
ORF Names:DDB_G0287459
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0287459, secG

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003344891 – 986Ankyrin repeat, PH and SEC7 domain containing protein secGAdd BLAST986

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54KA7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0191439

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54KA7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati34 – 63ANK 1Add BLAST30
Repeati68 – 97ANK 2Add BLAST30
Repeati101 – 131ANK 3Add BLAST31
Repeati135 – 164ANK 4Add BLAST30
Repeati168 – 197ANK 5Add BLAST30
Repeati201 – 230ANK 6Add BLAST30
Repeati234 – 263ANK 7Add BLAST30
Repeati267 – 296ANK 8Add BLAST30
Repeati300 – 329ANK 9Add BLAST30
Repeati334 – 363ANK 10Add BLAST30
Repeati367 – 396ANK 11Add BLAST30
Repeati400 – 429ANK 12Add BLAST30
Repeati433 – 462ANK 13Add BLAST30
Repeati466 – 495ANK 14Add BLAST30
Repeati499 – 528ANK 15Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini580 – 770SEC7PROSITE-ProRule annotationAdd BLAST191
Domaini784 – 895PHPROSITE-ProRule annotationAdd BLAST112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 43DisorderedSequence analysisAdd BLAST43
Regioni911 – 986DisorderedSequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi920 – 986Polar residuesSequence analysisAdd BLAST67

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0930, Eukaryota
KOG4177, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_302561_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54KA7

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHEPCGI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54KA7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171, Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit
1.25.40.20, 4 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 5 hits
PF00169, PH, 1 hit
PF01369, Sec7, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 15 hits
SM00233, PH, 1 hit
SM00222, Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 2 hits
SSF48425, SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 13 hits
PS50003, PH_DOMAIN, 1 hit
PS50190, SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54KA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSTSNSTKN TGSTTTTTTT AAPATTAKHS NSAPTRPSVH YYSSTGDIEK
60 70 80 90 100
LSNLLNNSAT SPDTPDSEKR TPLHHAAFCG SAACVNFLLD KKANANIKDS
110 120 130 140 150
AGNTPLQWAS SRGHLECIKL LVEKGGVDVN TKDDKNGTPL HKASLFASAE
160 170 180 190 200
CVLYLLNGKA DPRAVTTNGE TPLHHASAGG NPQCVELLIK ADSKVNAVDN
210 220 230 240 250
DCITPLHQAS FSGHSSCVSL LLKKGAKVDP RDIHGISPLH NAASAGYVDC
260 270 280 290 300
VEQLVRNGEN INCVDIEGVT PLHHTCFNGN LQLTKRLIEL GAKINMVDEM
310 320 330 340 350
GETPLHKAAF NGHKEVCEYL LYLDPTMIDC RDSRQSTSLH LAAFNGLLDM
360 370 380 390 400
VDLLIRYKAQ INIKDEEGAT PLHKASFNGH SSCAKLLVDK GAPICIVDSQ
410 420 430 440 450
GATPLHKAAF NGRSKCLATL IRSGAELEVK DSQGGTPLHN AAYNGHSDCC
460 470 480 490 500
RILLKKGANV NAVDTHSSTP LHLASAAGAR DTVDVLIQFK ARIDAKNFAG
510 520 530 540 550
KTPLVYAIKK NHSDVARVLI RAGADLDQVS LRSSVDFTKT FGTENHDEIY
560 570 580 590 600
QIVNKRESSN HEVDELQLAL EQQAKEDMEQ LAAEKQKLLL IKAAIAQFNS
610 620 630 640 650
HPKKGIEFIV ANGVISEKNP KEVAHFLLTH SELSKQSIGE YIGEGDDFNL
660 670 680 690 700
QVLHAFVDEL NFFGLDFDVA LRKYLLTFRL PGEAQKIDRM MEKFASQFYQ
710 720 730 740 750
HNPENKVFVN QDAVYVLAFS VIMLNTDAHN PNIKKKMTKA EFLRNNSGIN
760 770 780 790 800
SGDDLPPDFM ENLYDKIVTN EIKMERDGNQ ANQHVEKKGW LTKQGGRIKT
810 820 830 840 850
WKKRWFILTA NCLLYYKTPQ DHEPCGIIPL ENVVVTIDPQ KKFCFMLHSS
860 870 880 890 900
QEQMKACKLN SDGTLVQANH AAYFIAAANM AEMDSWVQSI KSNIHSNPNF
910 920 930 940 950
EQLLKRKAET IRGRGKVSTK PIQNRKQTIS GPPPSTTTTT TSTASNNVTS
960 970 980
VGSPPNSGSV LNSSGSKPVT FSSTSSPVQQ QTSALS
Length:986
Mass (Da):107,523
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AB5789F4A39788D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB36958 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000101 Genomic DNA Translation: EAL63695.1
U78755 mRNA Translation: AAB36958.1 Frameshift.

NCBI Reference Sequences

More...
RefSeqi
XP_637214.1, XM_632122.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL63695; EAL63695; DDB_G0287459

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8626150

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0287459

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000101 Genomic DNA Translation: EAL63695.1
U78755 mRNA Translation: AAB36958.1 Frameshift.
RefSeqiXP_637214.1, XM_632122.1

3D structure databases

SMRiQ54KA7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0191439

Proteomic databases

PaxDbiQ54KA7

Genome annotation databases

EnsemblProtistsiEAL63695; EAL63695; DDB_G0287459
GeneIDi8626150
KEGGiddi:DDB_G0287459

Organism-specific databases

dictyBaseiDDB_G0287459, secG

Phylogenomic databases

eggNOGiKOG0930, Eukaryota
KOG4177, Eukaryota
HOGENOMiCLU_302561_0_0_1
InParanoidiQ54KA7
OMAiDHEPCGI
PhylomeDBiQ54KA7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54KA7

Family and domain databases

CDDicd00171, Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
1.25.40.20, 4 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 5 hits
PF00169, PH, 1 hit
PF01369, Sec7, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 15 hits
SM00233, PH, 1 hit
SM00222, Sec7, 1 hit
SUPFAMiSSF48403, SSF48403, 2 hits
SSF48425, SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 13 hits
PS50003, PH_DOMAIN, 1 hit
PS50190, SEC7, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSECG_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54KA7
Secondary accession number(s): P90525
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 24, 2005
Last modified: February 23, 2022
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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