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Entry version 97 (16 Oct 2019)
Sequence version 1 (24 May 2005)
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Protein

ABC transporter C family member 3

Gene

abcC3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi474 – 481ATPPROSITE-ProRule annotation8
Nucleotide bindingi1096 – 1103ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-382556 ABC-family proteins mediated transport
R-DDI-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DDI-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC transporter C family member 3
Alternative name(s):
ABC transporter ABCC.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:abcC3
ORF Names:DDB_G0287691
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0287691 abcC3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei115 – 135HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei161 – 181HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei236 – 256HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei261 – 281HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei346 – 366HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei379 – 399HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei724 – 744HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei787 – 807HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei854 – 874HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei875 – 895HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei967 – 987HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003638491 – 1412ABC transporter C family member 3Add BLAST1412

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54JR2

PRoteomics IDEntifications database

More...
PRIDEi
Q54JR2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0216251

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54JR2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini119 – 405ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST287
Domaini439 – 662ABC transporter 1PROSITE-ProRule annotationAdd BLAST224
Domaini735 – 1025ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST291
Domaini1062 – 1296ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1368 – 1406Poly-AsnAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54JR2

Identification of Orthologs from Complete Genome Data

More...
OMAi
PWIMNAS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54JR2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54JR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELEEVGVEA NQPNNDQGSK KQNKNKDKKV KKEKKIGYGG KKSAEENSNF
60 70 80 90 100
ISWLTFSWAD RFVVHCFRHV LQLSHIWDLA SYDKSAYLAE KIAISWDVEI
110 120 130 140 150
KKPKPSYIRA AFRAFGLYFV LSWFFYAIYA ASQFVGPEIL KRMVTFVLKS
160 170 180 190 200
RSGISTEDPN MGYYYALIMF GSAMIGSVCL YQSNMISART GDRLRSVIVL
210 220 230 240 250
DVYRKAIKLS NSARANTSPG EIVNLMSNDA QRMVEVFQLV NNGVFALPQI
260 270 280 290 300
IVCLALLYRA IGWPTFVGLG LMLAAVPFNG IAAKKLTEIR RHLVGFTDKR
310 320 330 340 350
VKTTNEILQA IKIIKLYAWE DSFAKKVIER REAEIKLLFS FSRYRAMLIV
360 370 380 390 400
IVAALPTAVS VLVFSSYYGY YKKLDAGEIF AALSYLNILR LPLGFLPIIV
410 420 430 440 450
ALGIQMKIAA QRVTDFLLLP EMKEISKIED PSIENGIYIR DATLTWNQEK
460 470 480 490 500
KEESFTLKNI NFEAKGKTLT MIVGSVGSGK SSLIQAMLGE MDVLDGSVAM
510 520 530 540 550
KGNVAYVPQQ AWIINATLKD NILFGSPYDE AKYRKVLEVC ALERDIELFP
560 570 580 590 600
QGDLVEIGER GVNLSGGQKQ RVSIARAVYS DSDVYILDDP LSAVDAHVGK
610 620 630 640 650
HLFHRCFKGI LKSKTVILAA NQLNYLPFAH NTVVLKAGEI SERGSYQQLI
660 670 680 690 700
NAQKEFSGLL QAYGVDESAV NEDVEDDKEI EESDNIVVEE KTKPTEKPKL
710 720 730 740 750
QNKDGVLTSQ EEREEGAVAM WVYWKYITVG GGFLFLMAFI FFLMDTGTRT
760 770 780 790 800
FVDWWLSHWQ NESTKNALAV AQGLEPSGLT DTQYLGIYIG VGMTSILISA
810 820 830 840 850
GRNFLFFEYT VRASRALHHQ LFNALLRAPM SFFDTTPLGR IINRFTRDLD
860 870 880 890 900
GVDNLMATSI SQFLVFFTTV VATLIIISII TPFLLVPLAP ICIIFYFLQF
910 920 930 940 950
FYRYTSRELQ RLEAISRSPI FSHFSETLGG VVSIRAYRKK EENILTNQFR
960 970 980 990 1000
LDNNNKCYLT LQAMNQWLGL RLDLLANLVT FFACLFITID RDTISAANVG
1010 1020 1030 1040 1050
LSLSYALSLT GNLNRATLQA ADTETKMNSV ERITHYIKGP VEALQIVEDH
1060 1070 1080 1090 1100
RPAPDWPPHG AITFDNLVMR YREGLDPVLK GISCEIKAKE KIGIVGRTGA
1110 1120 1130 1140 1150
GKSSIVLALF RLIEASEGAI LIDGENIAKF GLKDLRRNLA IIPQDPVLFS
1160 1170 1180 1190 1200
GTLRENIDPF NEKTDDQLWS VLKDIQLHDV AKSLEGGLDS KVTENGDNWS
1210 1220 1230 1240 1250
VGQRQLLCLA RALLRDPKIL VLDEATASVD GHSDSLIQAT IREKFSNCTI
1260 1270 1280 1290 1300
LTIAHRLNTI MDSDRIIVLD AGKISEFDEP WTLLQNPAGL LNWLVEETGP
1310 1320 1330 1340 1350
QNAAYLRRLA QAKKDGVNID QITPPISPTP EQKPFKNADI DNINSPPQQS
1360 1370 1380 1390 1400
LKAEDNPNPK ALDNSGDNNN NNNNNNNNNN NNNNNNNNNN NNNNNNDNDN
1410
DNDNDNSEAG DN
Length:1,412
Mass (Da):158,111
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7742BD1171062F36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191 – 212Missing in AAL85706 (PubMed:12456012).CuratedAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF474335 Genomic DNA Translation: AAL85706.1
AAFI02000104 Genomic DNA Translation: EAL63492.1

NCBI Reference Sequences

More...
RefSeqi
XP_637090.1, XM_631998.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL63492; EAL63492; DDB_G0287691

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8626345

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0287691

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF474335 Genomic DNA Translation: AAL85706.1
AAFI02000104 Genomic DNA Translation: EAL63492.1
RefSeqiXP_637090.1, XM_631998.1

3D structure databases

SMRiQ54JR2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0216251

Proteomic databases

PaxDbiQ54JR2
PRIDEiQ54JR2

Genome annotation databases

EnsemblProtistsiEAL63492; EAL63492; DDB_G0287691
GeneIDi8626345
KEGGiddi:DDB_G0287691

Organism-specific databases

dictyBaseiDDB_G0287691 abcC3

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
InParanoidiQ54JR2
OMAiPWIMNAS
PhylomeDBiQ54JR2

Enzyme and pathway databases

ReactomeiR-DDI-382556 ABC-family proteins mediated transport
R-DDI-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DDI-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54JR2

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCC3_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54JR2
Secondary accession number(s): Q8T6H6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: October 16, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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