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Entry version 89 (23 Feb 2022)
Sequence version 3 (16 Jun 2009)
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Protein

RhoGEF domain-containing protein gxcI

Gene

gxcI

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-193648, NRAGE signals death through JNK
R-DDI-9013148, CDC42 GTPase cycle
R-DDI-9013406, RHOQ GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RhoGEF domain-containing protein gxcI
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gxcI
ORF Names:DDB_0233474
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0288383, gxcI

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003774351 – 1082RhoGEF domain-containing protein gxcIAdd BLAST1082

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54J11

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0304693

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54J11

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini622 – 817DHPROSITE-ProRule annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni59 – 78DisorderedSequence analysisAdd BLAST20
Regioni91 – 395DisorderedSequence analysisAdd BLAST305
Regioni438 – 488DisorderedSequence analysisAdd BLAST51
Regioni504 – 524DisorderedSequence analysisAdd BLAST21
Regioni838 – 994PH-likeAdd BLAST157
Regioni920 – 961DisorderedSequence analysisAdd BLAST42
Regioni1017 – 1060DisorderedSequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi91 – 160Polar residuesSequence analysisAdd BLAST70
Compositional biasi161 – 205Pro residuesSequence analysisAdd BLAST45
Compositional biasi206 – 255Polar residuesSequence analysisAdd BLAST50
Compositional biasi263 – 280Pro residuesSequence analysisAdd BLAST18
Compositional biasi281 – 368Polar residuesSequence analysisAdd BLAST88
Compositional biasi369 – 383Pro residuesSequence analysisAdd BLAST15
Compositional biasi438 – 469Polar residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH-like region is similar to the PH domain but contains an insert. It is unclear whether it is a real PH domain.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3519, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_285976_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54J11

Identification of Orthologs from Complete Genome Data

More...
OMAi
SNHANER

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54J11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKNSTSNPS PSHQFLTPPK NTTTVVNNNN NTFVNKNKII NENSNQKMFS
60 70 80 90 100
VGSLVNQIDK NQQQQQQQQQ QTHQVLPQRK FSGVSTMISK YNEQQPSSSS
110 120 130 140 150
STASSSSSPS LPPKPLLSTI NNINNSGSAN NNTPSNLSPN TLSPTSIIKK
160 170 180 190 200
NNNNNISGSP SPSPSPAPTP TILSPLPSPR RQLPTRPPSP LPKLPSRPTS
210 220 230 240 250
PVPPNPDEAL NTTTTNNNNN NNNNNNNNNN NNNNNNNNNN NNNNSDNNYI
260 270 280 290 300
SKLGSHSVKT LPIPPPNDKP APPPRPWSSS GTLTTPPTIA TTKTSTNINS
310 320 330 340 350
TNVKYQTLSP SSTTATTATT TTTINNNVTT PPTTPPSQTI AFNNNNNNNN
360 370 380 390 400
NNNNNNNNNN NSNNNKPLPP TSTKPPRPKI APRNDISPIP VTSLSTANIT
410 420 430 440 450
NTPTVVIEQT PIIAPIQDSQ NIAASDLRTL RQRTFTRKQA SMKLNGEDFS
460 470 480 490 500
SLSLSTTPTS VSPSTPSSAN PTPSTTPPSM SPSNSVSNEF LTINSNENIN
510 520 530 540 550
NDLINSFNSD DSNNSNNSNS SLSLASASSS ASTTTTSTNS LNDTSFNNIS
560 570 580 590 600
ININPNNGLS VSNFISSHKK KTSFISGTLR RDTLDIKTIL IEKINVQYTI
610 620 630 640 650
TTQLSQKPSR KSLLPPINSS TSFNKVIKEI IETEADYIDQ MEVIINLYYF
660 670 680 690 700
AALEMSKYKL MTANDIYQIF SNIEELYYVS LRLYPMLLNI IPVLDHENQY
710 720 730 740 750
PNIEEIFLYN SKAFQRYGSY LSTHDHSIKV LNSLIDGNNV VNQIFQYVKS
760 770 780 790 800
LPHSKQLNLQ SFLIKPCQRL CKYPLLLREL KKALPPEDDS LEAEEHHKIF
810 820 830 840 850
QRSLILMEKI VNDINGKMAN DNKIQSTVKE IGTKDIEQQL RDQTFLKSSN
860 870 880 890 900
RIKKLKKKGN KVIVTLYLLS QILIIFEKGT FKKKVKIIPL KNILEIIDIE
910 920 930 940 950
RELQFGISIN YLNDNDIQNN NNNNQNNLSS TNDTTSSTPP TTTTTTNSTP
960 970 980 990 1000
TTTTTTTNST PTVNVNTLSI KLSCDNYQDK LIWLNDIDEA INILKILTGS
1010 1020 1030 1040 1050
YKFNVSEKDI NININNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNINENN
1060 1070 1080
INENNINSNN TSLENSGECI NNNINNNNNT SN
Length:1,082
Mass (Da):119,579
Last modified:June 16, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A5EEE2295501560
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000111 Genomic DNA Translation: EAL63217.3

NCBI Reference Sequences

More...
RefSeqi
XP_636719.3, XM_631627.3

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL63217; EAL63217; DDB_G0288383

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8626595

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0288383

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000111 Genomic DNA Translation: EAL63217.3
RefSeqiXP_636719.3, XM_631627.3

3D structure databases

SMRiQ54J11
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0304693

Proteomic databases

PaxDbiQ54J11

Genome annotation databases

EnsemblProtistsiEAL63217; EAL63217; DDB_G0288383
GeneIDi8626595
KEGGiddi:DDB_G0288383

Organism-specific databases

dictyBaseiDDB_G0288383, gxcI

Phylogenomic databases

eggNOGiKOG3519, Eukaryota
HOGENOMiCLU_285976_0_0_1
InParanoidiQ54J11
OMAiSNHANER

Enzyme and pathway databases

ReactomeiR-DDI-193648, NRAGE signals death through JNK
R-DDI-9013148, CDC42 GTPase cycle
R-DDI-9013406, RHOQ GTPase cycle

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54J11

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
PfamiView protein in Pfam
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGXCI_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54J11
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: February 23, 2022
This is version 89 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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