We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q54J11 (GXCI_DICDI)
Protein
RhoGEF domain-containing protein gxcI
Gene
gxcI
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
GTPase-activating protein.
By similarityGO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Enzyme and pathway databases
Reactomei | R-DDI-193648, NRAGE signals death through JNK R-DDI-9013148, CDC42 GTPase cycle R-DDI-9013406, RHOQ GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: RhoGEF domain-containing protein gxcI |
Gene namesi | Name:gxcI ORF Names:DDB_0233474 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0288383, gxcI |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000377435 | 1 – 1082 | RhoGEF domain-containing protein gxcIAdd BLAST | 1082 |
Proteomic databases
PaxDbi | Q54J11 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 622 – 817 | DHPROSITE-ProRule annotationAdd BLAST | 196 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 59 – 78 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 91 – 395 | DisorderedSequence analysisAdd BLAST | 305 | |
Regioni | 438 – 488 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 504 – 524 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 838 – 994 | PH-likeAdd BLAST | 157 | |
Regioni | 920 – 961 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 1017 – 1060 | DisorderedSequence analysisAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 91 – 160 | Polar residuesSequence analysisAdd BLAST | 70 | |
Compositional biasi | 161 – 205 | Pro residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 206 – 255 | Polar residuesSequence analysisAdd BLAST | 50 | |
Compositional biasi | 263 – 280 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 281 – 368 | Polar residuesSequence analysisAdd BLAST | 88 | |
Compositional biasi | 369 – 383 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 438 – 469 | Polar residuesSequence analysisAdd BLAST | 32 |
Domaini
The PH-like region is similar to the PH domain but contains an insert. It is unclear whether it is a real PH domain.
Phylogenomic databases
eggNOGi | KOG3519, Eukaryota |
HOGENOMi | CLU_285976_0_0_1 |
InParanoidi | Q54J11 |
OMAi | SNHANER |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain |
Pfami | View protein in Pfam PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54J11-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKNSTSNPS PSHQFLTPPK NTTTVVNNNN NTFVNKNKII NENSNQKMFS
60 70 80 90 100
VGSLVNQIDK NQQQQQQQQQ QTHQVLPQRK FSGVSTMISK YNEQQPSSSS
110 120 130 140 150
STASSSSSPS LPPKPLLSTI NNINNSGSAN NNTPSNLSPN TLSPTSIIKK
160 170 180 190 200
NNNNNISGSP SPSPSPAPTP TILSPLPSPR RQLPTRPPSP LPKLPSRPTS
210 220 230 240 250
PVPPNPDEAL NTTTTNNNNN NNNNNNNNNN NNNNNNNNNN NNNNSDNNYI
260 270 280 290 300
SKLGSHSVKT LPIPPPNDKP APPPRPWSSS GTLTTPPTIA TTKTSTNINS
310 320 330 340 350
TNVKYQTLSP SSTTATTATT TTTINNNVTT PPTTPPSQTI AFNNNNNNNN
360 370 380 390 400
NNNNNNNNNN NSNNNKPLPP TSTKPPRPKI APRNDISPIP VTSLSTANIT
410 420 430 440 450
NTPTVVIEQT PIIAPIQDSQ NIAASDLRTL RQRTFTRKQA SMKLNGEDFS
460 470 480 490 500
SLSLSTTPTS VSPSTPSSAN PTPSTTPPSM SPSNSVSNEF LTINSNENIN
510 520 530 540 550
NDLINSFNSD DSNNSNNSNS SLSLASASSS ASTTTTSTNS LNDTSFNNIS
560 570 580 590 600
ININPNNGLS VSNFISSHKK KTSFISGTLR RDTLDIKTIL IEKINVQYTI
610 620 630 640 650
TTQLSQKPSR KSLLPPINSS TSFNKVIKEI IETEADYIDQ MEVIINLYYF
660 670 680 690 700
AALEMSKYKL MTANDIYQIF SNIEELYYVS LRLYPMLLNI IPVLDHENQY
710 720 730 740 750
PNIEEIFLYN SKAFQRYGSY LSTHDHSIKV LNSLIDGNNV VNQIFQYVKS
760 770 780 790 800
LPHSKQLNLQ SFLIKPCQRL CKYPLLLREL KKALPPEDDS LEAEEHHKIF
810 820 830 840 850
QRSLILMEKI VNDINGKMAN DNKIQSTVKE IGTKDIEQQL RDQTFLKSSN
860 870 880 890 900
RIKKLKKKGN KVIVTLYLLS QILIIFEKGT FKKKVKIIPL KNILEIIDIE
910 920 930 940 950
RELQFGISIN YLNDNDIQNN NNNNQNNLSS TNDTTSSTPP TTTTTTNSTP
960 970 980 990 1000
TTTTTTTNST PTVNVNTLSI KLSCDNYQDK LIWLNDIDEA INILKILTGS
1010 1020 1030 1040 1050
YKFNVSEKDI NININNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNINENN
1060 1070 1080
INENNINSNN TSLENSGECI NNNINNNNNT SN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000111 Genomic DNA Translation: EAL63217.3 |
RefSeqi | XP_636719.3, XM_631627.3 |
Genome annotation databases
EnsemblProtistsi | EAL63217; EAL63217; DDB_G0288383 |
GeneIDi | 8626595 |
KEGGi | ddi:DDB_G0288383 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000111 Genomic DNA Translation: EAL63217.3 |
RefSeqi | XP_636719.3, XM_631627.3 |
3D structure databases
SMRi | Q54J11 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0304693 |
Proteomic databases
PaxDbi | Q54J11 |
Genome annotation databases
EnsemblProtistsi | EAL63217; EAL63217; DDB_G0288383 |
GeneIDi | 8626595 |
KEGGi | ddi:DDB_G0288383 |
Organism-specific databases
dictyBasei | DDB_G0288383, gxcI |
Phylogenomic databases
eggNOGi | KOG3519, Eukaryota |
HOGENOMi | CLU_285976_0_0_1 |
InParanoidi | Q54J11 |
OMAi | SNHANER |
Enzyme and pathway databases
Reactomei | R-DDI-193648, NRAGE signals death through JNK R-DDI-9013148, CDC42 GTPase cycle R-DDI-9013406, RHOQ GTPase cycle |
Miscellaneous databases
PROi | PR:Q54J11 |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain |
Pfami | View protein in Pfam PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GXCI_DICDI | |
Accessioni | Q54J11Primary (citable) accession number: Q54J11 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2009 |
Last sequence update: | June 16, 2009 | |
Last modified: | February 23, 2022 | |
This is version 89 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase