Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 77 (07 Nov 2018)
Sequence version 1 (24 May 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Component of gems protein 5

Gene

gemin5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Gemin5 acts as the snRNA-binding protein of the SMN complex. Binds to the 7-methylguanosine cap of RNA molecules.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Component of gems protein 5
Alternative name(s):
Gemin-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gemin5
ORF Names:DDB_G0288425
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0288425 gemin5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003713421 – 1276Component of gems protein 5Add BLAST1276

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54IY5

PRoteomics IDEntifications database

More...
PRIDEi
Q54IY5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the core SMN complex.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei368Interaction with U4 snRNABy similarity1
Sitei413Interaction with U4 snRNABy similarity1
Sitei466Interaction with U4 snRNABy similarity1
Sitei486Interaction with U4 snRNABy similarity1
Sitei528Interaction with U4 snRNABy similarity1
Sitei579Interaction with U4 snRNABy similarity1
Sitei583Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA moleculesBy similarity1
Sitei732Interaction with U4 snRNABy similarity1
Sitei910Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA moleculesBy similarity1

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0302538

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q54IY5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati92 – 139WD 1Add BLAST48
Repeati183 – 223WD 2Add BLAST41
Repeati228 – 268WD 3Add BLAST41
Repeati271 – 336WD 4Add BLAST66
Repeati364 – 405WD 5Add BLAST42
Repeati438 – 481WD 6Add BLAST44
Repeati485 – 522WD 7Add BLAST38
Repeati530 – 574WD 8Add BLAST45
Repeati688 – 727WD 9Add BLAST40
Repeati729 – 771WD 10Add BLAST43
Repeati863 – 903WD 11Add BLAST41
Repeati906 – 946WD 12Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 55Interaction with U4 snRNABy similarity3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili778 – 829Sequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi151 – 156Poly-Gly6
Compositional biasi159 – 162Poly-Gly4
Compositional biasi353 – 356Poly-Ser4
Compositional biasi357 – 360Poly-Gly4
Compositional biasi598 – 646Poly-AsnAdd BLAST49
Compositional biasi817 – 822Poly-Asn6
Compositional biasi845 – 850Poly-Asn6
Compositional biasi970 – 978Poly-Gln9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WD repeat domain mediates binding to U1 snRNA and to U4 snRNA. The WD repeat domain also mediates binding to the 7-methylguanosine cap that is found both on mRNA and snRNA molecules. The regions that bind snRNA molecules and the isolated 7-methylguanosine cap overlap at least partially. Besides, the WD repeat domain mediates interaction with the 60S large ribosomal subunit.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat gemin-5 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJDN Eukaryota
ENOG410XTH3 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54IY5

KEGG Orthology (KO)

More...
KOi
K13133

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLACCPH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54IY5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54IY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIDSNIIKN ENLINANNHT DRRDVHDSLA EAPEKITELK KNHWEELLPS
60 70 80 90 100
SSNWYCTSVA DCNENQIYIY ACKSNVSIFN IKSKKFIGEL NGHTDRVTSV
110 120 130 140 150
GFFKRFESKN DESYKWCITG SDDKTVRIWK FNSNDDDHNE DTEIGDDFKH
160 170 180 190 200
GSGGGGSDGG GGDDVNNFYG NKSSNFCIYY HQEHKAGVTC VVASPLVPDL
210 220 230 240 250
VLSGDKAGAL VIYRTLTNHV FPIPPIIGNN ISISTLAFSP NHSDLVAIGY
260 270 280 290 300
LNGIVLIYNF VIRSTVCKIS AHSADVLSIV WFDSTIIQKN NIFHDNNIND
310 320 330 340 350
QDDNNSNHRN RIFLATCSKD KAIKIWKQVG EKIESGFTNI YQFNPSKYSI
360 370 380 390 400
QHSSSSGGGG INQNDKQRVW LTLSWSPESP QYLLSNSLTA DVLIWDLINF
410 420 430 440 450
KSPPEKFQSS HQRLIFNITQ IPNSDGSLAK TTATTETTTK NKIKNKDKKQ
460 470 480 490 500
SQIKLNNKVI TVSLDRQIII WENLKAKIKI QGLGGFVYSI DTCSYSPNTF
510 520 530 540 550
AIGCGDNTIR LWSPTENSKD AYESKTLWKG IQSKVTSLSI CKDYGFSNSN
560 570 580 590 600
LIAFGMDDGR VGVYNINTNQ SKIFPGGHKN EIYEIIWKPP PTPTPQKNIN
610 620 630 640 650
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNINNNN NNNSNNEQQP
660 670 680 690 700
NKLYSIGNNE IYEWDYNDFN KSFTNMTPII QQLNPKETFS KHKTDINFNL
710 720 730 740 750
NGDMISIGYS DGTIDIFTSE FLFLTRIREH KKLINRVQWN HFKENEMILA
760 770 780 790 800
SASTDKKVII YKLSKIGNQN ENEKKIDNEK GKENENEKGK ENENENENEN
810 820 830 840 850
ENENENENEN EIENIVNNNN ENDTEIEIKN INKNENVDKE EMVENNNNNN
860 870 880 890 900
IKYKIEILHQ FIGHKNNVCS VSWSNVDPNL LGSASADGTV QVWNIKSKEA
910 920 930 940 950
ISNMRGHDGR VFTVCWSLLD PNLLVSGGED QTVRLWNYST QPFKTVTESQ
960 970 980 990 1000
IKKSPQPELS ISLNKKITEQ QQQQQQPQSP IKSNPDQSNN PSLVPPILLT
1010 1020 1030 1040 1050
SVTSTSNTTA TATTITQITE SLPKKRPIFL LNKDIVQRQD SSQYVVPLAK
1060 1070 1080 1090 1100
YFTTNDQDSI NTNETKQEYE FGSNSENNNS KIEAIFSEKK EIINKLVQKE
1110 1120 1130 1140 1150
SLELLKIDDV ENYISLNSWN PANLKQALYQ VIKNGKLTGN IVSLSIQAGR
1160 1170 1180 1190 1200
EIFESICNLY SQQLICIGDY HLAVSYLLMI GKVNEAIEVY RNTLLFQEAI
1210 1220 1230 1240 1250
ILAKSRFLPD DPIINKLFTE WAKQTETSHP IHSIKCYLAT INDQSLNSKQ
1260 1270
ELLKLLSSVQ TKQIIKIQSD LEQILK
Length:1,276
Mass (Da):144,531
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7A44B91C55E8A80
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000111 Genomic DNA Translation: EAL63238.1

NCBI Reference Sequences

More...
RefSeqi
XP_636745.1, XM_631653.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL63238; EAL63238; DDB_G0288425

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8626623

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0288425

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000111 Genomic DNA Translation: EAL63238.1
RefSeqiXP_636745.1, XM_631653.1

3D structure databases

ProteinModelPortaliQ54IY5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0302538

Proteomic databases

PaxDbiQ54IY5
PRIDEiQ54IY5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL63238; EAL63238; DDB_G0288425
GeneIDi8626623
KEGGiddi:DDB_G0288425

Organism-specific databases

dictyBaseiDDB_G0288425 gemin5

Phylogenomic databases

eggNOGiENOG410IJDN Eukaryota
ENOG410XTH3 LUCA
InParanoidiQ54IY5
KOiK13133
OMAiCLACCPH
PhylomeDBiQ54IY5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54IY5

Family and domain databases

Gene3Di2.130.10.10, 5 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
SMARTiView protein in SMART
SM00320 WD40, 13 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGEMI5_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54IY5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again