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UniProtKB - Q54IX3 (PKS26_DICDI)
Protein
Probable polyketide synthase 26
Gene
pks26
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes localized in chromosome 5.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 174 | For beta-ketoacyl synthase activityBy similarity | 1 | |
Active sitei | 630 | For acyl/malonyl transferase activityBy similarity | 1 |
GO - Molecular functioni
- acyltransferase activity Source: InterPro
- oxidoreductase activity Source: InterPro
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pks26 ORF Names:DDB_G0288457 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0288457, pks26 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000371388 | 1 – 2531 | Probable polyketide synthase 26Add BLAST | 2531 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2468 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | Q54IX3 |
PRIDEi | Q54IX3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2431 – 2509 | CarrierPROSITE-ProRule annotationAdd BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 155 – 208 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 620 – 653 | Acyl/malonyl transferaseAdd BLAST | 34 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | Q54IX3 |
PhylomeDBi | Q54IX3 |
Family and domain databases
Gene3Di | 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR011032, GroES-like_sf IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54IX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METNNNKNIQ EDIAIIGFRI PGCQDNTPSE LWNNLMNKFS GVGKTTERWS
60 70 80 90 100
DNYHLSGDIN NGNSGLLPLK EWKKFDPAFF GINPTMVSTI DPQQRILLKC
110 120 130 140 150
TWEALEDAGI DPIKLRGSNT SIFIGCSTGD YLDMVKSNNE IQTNLFGSVN
160 170 180 190 200
HSLSNRISYC FDFHGASMTI DSACSSSLNT VLLGCQSINQ GKSNLCIAGG
210 220 230 240 250
VNFILDTTIP TAFSFLNILS KNGKCMTYDE GADGFVRGEG AGLVVLKSLK
260 270 280 290 300
DAIKDGNNIY CIIKGGNTNV DGNGNADKAN FFQPSKQSQS DNIKLALESI
310 320 330 340 350
KKKSMLDIDI DYVETHGTGT PTGDPIEVEG ISKVFKENHS PENPLLIGSL
360 370 380 390 400
KSNIGHMEAA SGVTSLIKCC LMFKNKSFAP NVNFQKINPK IKLDEWNIKV
410 420 430 440 450
VTEAIPFKKN KITSMVVNSF GVTGSNCCLV LTESINNNNN SNVDKITKNE
460 470 480 490 500
KEYLIPFSAN SNQSLKNYIE EVSKIDESLQ FEDFVYKQLS NKSTSLFQRF
510 520 530 540 550
VVTSKDWKEL KYKLSQPLPL KEISSSISVK KPNPITVFVF CGQGSQFNKM
560 570 580 590 600
GLELYNNDKN FRNYIDRFDK KLLEYYGYSV ISKLRSIDDN DLITIHDPII
610 620 630 640 650
AQPATAILQI SLFELYKHWG INPSFIVGHS LGELPMAFCS GMIDFDTVCY
660 670 680 690 700
LLYHRSLAQS KTNGCGKMLS CNISSEEFVK NYSPRYPFLE IACYNSPNSI
710 720 730 740 750
VVAGKESILL ELSKEFKNSG IFCAMLGSLS SFHTSSQLEV KDHIYSLKFE
760 770 780 790 800
SKEPVIPTFS TVTTHLFNSN KLYDNDYIFQ NIMKPVLFNE TISNLYKHVE
810 820 830 840 850
NNQLGSEMIF IELAPHQTLS FYLKQLIPKD SNYFSNSNSI TILSPLHKKK
860 870 880 890 900
NDYLEIQQTI STCYCKGYDV NFKSQILIES KTNISNKSLP LYQWDDKEFW
910 920 930 940 950
KDLEKQKRIL QGPPMDTLGF SNEKSPILKS FETKIDIKKK PFQYLKGHIV
960 970 980 990 1000
KGKIYFPGVG YIENLLKMYP SQDIDIDSME FEAPLILIEG IVTCLQSNVY
1010 1020 1030 1040 1050
KIGKNEFKVQ FHFQDQKTKQ WIQSSFANYH LSHRDDFDPT TNKLNIQNLI
1060 1070 1080 1090 1100
SNNCNLTKLS KNQFYNFIKA KAGLSYNGEF QGVEKCYLGD NCSLVEIPFD
1110 1120 1130 1140 1150
TSNQDVETNI NMIPILDSCL HGVHILYVEQ CQMVLEKIEG LKYYSSTLIL
1160 1170 1180 1190 1200
SKQKEQQKLY VFTRIENKDL INNSISASII VMISDGTVFF EIESVSLKSL
1210 1220 1230 1240 1250
IPLKDPISIE NPTDELFSSY LQSIDSLISE PSSYKSIYKR NEFISSGMSD
1260 1270 1280 1290 1300
LSRSDYQQFI STLLYTNLIK RNQSIESDLR NQIEFEEIKA KYCKNSKFER
1310 1320 1330 1340 1350
LFTFVIETIK QYDGINGNLN SWNEGNIDIY KILIKSTRII SKLLFPLQGE
1360 1370 1380 1390 1400
DTTIDTPQSL FENNLLDDFY NINGNTVIQN QLVGEIITQS IKPLINEKMV
1410 1420 1430 1440 1450
FRILEFGGGV GSLSIVTLNK INQLLEQHPN FQIDIEYTWT DISPSFIPDA
1460 1470 1480 1490 1500
KKLLSNIKGV TIIYRSLDLE ESLIEKQLLK PSYYDFVIMS NVLHVIKEIK
1510 1520 1530 1540 1550
FGIDEIYKVL SPNGQLLFIE TPYRMLICDS IFGVFDQWWG FTDTGIRVDR
1560 1570 1580 1590 1600
CCMKQKTWFK LLSESNYQDI IMSDDIKDCC FVIQAKKPSI SSLEYKLKID
1610 1620 1630 1640 1650
SQENDKIIVF GENDTFMKYL ENKSTKQIIK IKTCQQFSDL ITSNSKEINN
1660 1670 1680 1690 1700
QSIIYFIKTL NQLLIENFKE ITLEYIQINQ LLLSSGLSCK HILLLNQSTS
1710 1720 1730 1740 1750
ENYLGSSISG AARYFDEFPP LKLYSFDFDK YSLNNESINI IDDIIEPIIK
1760 1770 1780 1790 1800
SMNNSNIRKE LLVRNNKIFF ERYKQEKRIK ENYKSTSFEN DKSLFVHLNA
1810 1820 1830 1840 1850
NLEYELKSKQ VKLKQNEIEV NVKATGINYK DYLVYTAMTP SELINHKGES
1860 1870 1880 1890 1900
NPEFGHDFSG IITRIGDDDG DNDNEFKVGD QVYGIWFNTT ASHIIVDKEF
1910 1920 1930 1940 1950
LCHKPSKLSH TIASSIPVVY ITSLYSLYNI GNIQNDESIL IHSASGGIGL
1960 1970 1980 1990 2000
SALNILKWKN HKSHIFVTVG SKEKEKYIHD TYGDFITGIY SSRNKDYLKL
2010 2020 2030 2040 2050
IKRKLTELGS NKKGVDIILN TLSSSEHMVS NFKCLNHRGR IIDLSITHLN
2060 2070 2080 2090 2100
HNEYTCNNNF KYNYGYHNVE VLFVKGDIIS KLLKNITSAI ENGSLSTGIP
2110 2120 2130 2140 2150
IIEFNDSDCF NAIEFINKRQ HIGKIVVNHN KENLIQELIK KTNLPIIKSN
2160 2170 2180 2190 2200
YQINSDHLGK NILVTGQSGI ILEILKWIVK YSTNVENIII LSRSSLKWEL
2210 2220 2230 2240 2250
ELLVNKNKNK LNFIYKSVDV GNSLEIEKVI DEILMENPQI NNVDSIFHYA
2260 2270 2280 2290 2300
FTQISCKEHE IDQVHLNVSH QAKTMGAINL HNQSIKRNWK LINFIMASSA
2310 2320 2330 2340 2350
AGLIGSTDQC SYVCSSNVLD TFSKYRKHVL GLPSICINYG LIESTGFVSR
2360 2370 2380 2390 2400
NQSVAVMLDG QGIRPMQTNQ ILGSLDLFIQ NPSKSTNIIL TSFNFNEFAT
2410 2420 2430 2440 2450
GNLQQSNVHK FDFQFNCCLS QKSKLMANNQ ASENPVKDLL INNICELLSI
2460 2470 2480 2490 2500
DESKLNIDIR LIDYGSDSLT IVQIKNLIDK NLLIPNLISI QMLQNNSISD
2510 2520 2530
NIKILTDSYN KKKQNEQNEL KNIKVGSFTK K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000111 Genomic DNA Translation: EAL63254.1 |
RefSeqi | XP_636757.1, XM_631665.1 |
Genome annotation databases
EnsemblProtistsi | EAL63254; EAL63254; DDB_G0288457 |
GeneIDi | 8626635 |
KEGGi | ddi:DDB_G0288457 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000111 Genomic DNA Translation: EAL63254.1 |
RefSeqi | XP_636757.1, XM_631665.1 |
3D structure databases
SMRi | Q54IX3 |
ModBasei | Search... |
Proteomic databases
PaxDbi | Q54IX3 |
PRIDEi | Q54IX3 |
Genome annotation databases
EnsemblProtistsi | EAL63254; EAL63254; DDB_G0288457 |
GeneIDi | 8626635 |
KEGGi | ddi:DDB_G0288457 |
Organism-specific databases
dictyBasei | DDB_G0288457, pks26 |
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | Q54IX3 |
PhylomeDBi | Q54IX3 |
Miscellaneous databases
PROi | PR:Q54IX3 |
Family and domain databases
Gene3Di | 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR011032, GroES-like_sf IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS26_DICDI | |
Accessioni | Q54IX3Primary (citable) accession number: Q54IX3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase