pks26

Functionⁱ

Probable polyketide synthase.By similarity

Miscellaneous

Encoded by one of the numerous copies of polyketide synthase genes localized in chromosome 5.

Cofactorⁱ

pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	174	For beta-ketoacyl synthase activityBy similarity		1
Active siteⁱ	630	For acyl/malonyl transferase activityBy similarity		1

GO - Molecular functionⁱ

oxidoreductase activity Source: InterPro
transferase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase

Molecular function

Transferase

Enzyme and pathway databases

Reactomeⁱ	R-DDI-163765 ChREBP activates metabolic gene expression R-DDI-199220 Vitamin B5 (pantothenate) metabolism R-DDI-75105 Fatty acyl-CoA biosynthesis

Reactomeⁱ

R-DDI-163765 ChREBP activates metabolic gene expression
R-DDI-199220 Vitamin B5 (pantothenate) metabolism
R-DDI-75105 Fatty acyl-CoA biosynthesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable polyketide synthase 26 (EC:2.3.1.-) Short name: dipks26
Gene namesⁱ	Name:pks26 ORF Names:DDB_G0288457
Organismⁱ	Dictyostelium discoideum (Slime mold)
Taxonomic identifierⁱ	44689 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyostelids › Dictyosteliales › Dictyosteliaceae › Dictyostelium
Proteomesⁱ	UP000002195 Componentsⁱ: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseⁱ	DDB_G0288457 pks26

dictyBaseⁱ

DDB_G0288457 pks26

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000371388	1 – 2531	Probable polyketide synthase 26Add BLAST		2531

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2468	O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation		1

Keywords - PTMⁱ

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q54IX3
PRIDEⁱ	Q54IX3

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	44689.DDB0235218

STRINGⁱ

44689.DDB0235218

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q54IX3
SMRⁱ	Q54IX3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2431 – 2509	CarrierPROSITE-ProRule annotationAdd BLAST		79

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	155 – 208	Beta-ketoacyl synthaseAdd BLAST		54
Regionⁱ	620 – 653	Acyl/malonyl transferaseAdd BLAST		34

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	436 – 442	Poly-Asn		7

Domainⁱ

Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity

Phylogenomic databases

eggNOGⁱ	KOG1202 Eukaryota ENOG410XNPJ LUCA
InParanoidⁱ	Q54IX3
PhylomeDBⁱ	Q54IX3

Family and domain databases

Gene3Dⁱ	3.40.366.10, 1 hit 3.40.47.10, 1 hit
InterProⁱ	View protein in InterPro IPR001227 Ac_transferase_dom_sf IPR036736 ACP-like_sf IPR014043 Acyl_transferase IPR016035 Acyl_Trfase/lysoPLipase IPR013154 ADH_N IPR011032 GroES-like_sf IPR032821 KAsynt_C_assoc IPR014031 Ketoacyl_synth_C IPR014030 Ketoacyl_synth_N IPR016036 Malonyl_transacylase_ACP-bd IPR013217 Methyltransf_12 IPR036291 NAD(P)-bd_dom_sf IPR020801 PKS_acyl_transferase IPR020841 PKS_Beta-ketoAc_synthase_dom IPR020807 PKS_dehydratase IPR020843 PKS_ER IPR013968 PKS_KR IPR009081 PP-bd_ACP IPR029063 SAM-dependent_MTases IPR016039 Thiolase-like
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00698 Acyl_transf_1, 1 hit PF08240 ADH_N, 1 hit PF16197 KAsynt_C_assoc, 1 hit PF00109 ketoacyl-synt, 1 hit PF02801 Ketoacyl-synt_C, 1 hit PF08659 KR, 1 hit PF08242 Methyltransf_12, 1 hit PF14765 PS-DH, 1 hit
SMARTⁱ	View protein in SMART SM00827 PKS_AT, 1 hit SM00829 PKS_ER, 1 hit SM00825 PKS_KS, 1 hit
SUPFAMⁱ	SSF47336 SSF47336, 1 hit SSF50129 SSF50129, 1 hit SSF51735 SSF51735, 2 hits SSF52151 SSF52151, 2 hits SSF53335 SSF53335, 1 hit SSF53901 SSF53901, 1 hit SSF55048 SSF55048, 1 hit
PROSITEⁱ	View protein in PROSITE PS50075 CARRIER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q54IX3-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
METNNNKNIQ EDIAIIGFRI PGCQDNTPSE LWNNLMNKFS GVGKTTERWS 
        60         70         80         90        100
DNYHLSGDIN NGNSGLLPLK EWKKFDPAFF GINPTMVSTI DPQQRILLKC 
       110        120        130        140        150
TWEALEDAGI DPIKLRGSNT SIFIGCSTGD YLDMVKSNNE IQTNLFGSVN 
       160        170        180        190        200
HSLSNRISYC FDFHGASMTI DSACSSSLNT VLLGCQSINQ GKSNLCIAGG 
       210        220        230        240        250
VNFILDTTIP TAFSFLNILS KNGKCMTYDE GADGFVRGEG AGLVVLKSLK 
       260        270        280        290        300
DAIKDGNNIY CIIKGGNTNV DGNGNADKAN FFQPSKQSQS DNIKLALESI 
       310        320        330        340        350
KKKSMLDIDI DYVETHGTGT PTGDPIEVEG ISKVFKENHS PENPLLIGSL 
       360        370        380        390        400
KSNIGHMEAA SGVTSLIKCC LMFKNKSFAP NVNFQKINPK IKLDEWNIKV 
       410        420        430        440        450
VTEAIPFKKN KITSMVVNSF GVTGSNCCLV LTESINNNNN SNVDKITKNE 
       460        470        480        490        500
KEYLIPFSAN SNQSLKNYIE EVSKIDESLQ FEDFVYKQLS NKSTSLFQRF 
       510        520        530        540        550
VVTSKDWKEL KYKLSQPLPL KEISSSISVK KPNPITVFVF CGQGSQFNKM 
       560        570        580        590        600
GLELYNNDKN FRNYIDRFDK KLLEYYGYSV ISKLRSIDDN DLITIHDPII 
       610        620        630        640        650
AQPATAILQI SLFELYKHWG INPSFIVGHS LGELPMAFCS GMIDFDTVCY 
       660        670        680        690        700
LLYHRSLAQS KTNGCGKMLS CNISSEEFVK NYSPRYPFLE IACYNSPNSI 
       710        720        730        740        750
VVAGKESILL ELSKEFKNSG IFCAMLGSLS SFHTSSQLEV KDHIYSLKFE 
       760        770        780        790        800
SKEPVIPTFS TVTTHLFNSN KLYDNDYIFQ NIMKPVLFNE TISNLYKHVE 
       810        820        830        840        850
NNQLGSEMIF IELAPHQTLS FYLKQLIPKD SNYFSNSNSI TILSPLHKKK 
       860        870        880        890        900
NDYLEIQQTI STCYCKGYDV NFKSQILIES KTNISNKSLP LYQWDDKEFW 
       910        920        930        940        950
KDLEKQKRIL QGPPMDTLGF SNEKSPILKS FETKIDIKKK PFQYLKGHIV 
       960        970        980        990       1000
KGKIYFPGVG YIENLLKMYP SQDIDIDSME FEAPLILIEG IVTCLQSNVY 
      1010       1020       1030       1040       1050
KIGKNEFKVQ FHFQDQKTKQ WIQSSFANYH LSHRDDFDPT TNKLNIQNLI 
      1060       1070       1080       1090       1100
SNNCNLTKLS KNQFYNFIKA KAGLSYNGEF QGVEKCYLGD NCSLVEIPFD 
      1110       1120       1130       1140       1150
TSNQDVETNI NMIPILDSCL HGVHILYVEQ CQMVLEKIEG LKYYSSTLIL 
      1160       1170       1180       1190       1200
SKQKEQQKLY VFTRIENKDL INNSISASII VMISDGTVFF EIESVSLKSL 
      1210       1220       1230       1240       1250
IPLKDPISIE NPTDELFSSY LQSIDSLISE PSSYKSIYKR NEFISSGMSD 
      1260       1270       1280       1290       1300
LSRSDYQQFI STLLYTNLIK RNQSIESDLR NQIEFEEIKA KYCKNSKFER 
      1310       1320       1330       1340       1350
LFTFVIETIK QYDGINGNLN SWNEGNIDIY KILIKSTRII SKLLFPLQGE 
      1360       1370       1380       1390       1400
DTTIDTPQSL FENNLLDDFY NINGNTVIQN QLVGEIITQS IKPLINEKMV 
      1410       1420       1430       1440       1450
FRILEFGGGV GSLSIVTLNK INQLLEQHPN FQIDIEYTWT DISPSFIPDA 
      1460       1470       1480       1490       1500
KKLLSNIKGV TIIYRSLDLE ESLIEKQLLK PSYYDFVIMS NVLHVIKEIK 
      1510       1520       1530       1540       1550
FGIDEIYKVL SPNGQLLFIE TPYRMLICDS IFGVFDQWWG FTDTGIRVDR 
      1560       1570       1580       1590       1600
CCMKQKTWFK LLSESNYQDI IMSDDIKDCC FVIQAKKPSI SSLEYKLKID 
      1610       1620       1630       1640       1650
SQENDKIIVF GENDTFMKYL ENKSTKQIIK IKTCQQFSDL ITSNSKEINN 
      1660       1670       1680       1690       1700
QSIIYFIKTL NQLLIENFKE ITLEYIQINQ LLLSSGLSCK HILLLNQSTS 
      1710       1720       1730       1740       1750
ENYLGSSISG AARYFDEFPP LKLYSFDFDK YSLNNESINI IDDIIEPIIK 
      1760       1770       1780       1790       1800
SMNNSNIRKE LLVRNNKIFF ERYKQEKRIK ENYKSTSFEN DKSLFVHLNA 
      1810       1820       1830       1840       1850
NLEYELKSKQ VKLKQNEIEV NVKATGINYK DYLVYTAMTP SELINHKGES 
      1860       1870       1880       1890       1900
NPEFGHDFSG IITRIGDDDG DNDNEFKVGD QVYGIWFNTT ASHIIVDKEF 
      1910       1920       1930       1940       1950
LCHKPSKLSH TIASSIPVVY ITSLYSLYNI GNIQNDESIL IHSASGGIGL 
      1960       1970       1980       1990       2000
SALNILKWKN HKSHIFVTVG SKEKEKYIHD TYGDFITGIY SSRNKDYLKL 
      2010       2020       2030       2040       2050
IKRKLTELGS NKKGVDIILN TLSSSEHMVS NFKCLNHRGR IIDLSITHLN 
      2060       2070       2080       2090       2100
HNEYTCNNNF KYNYGYHNVE VLFVKGDIIS KLLKNITSAI ENGSLSTGIP 
      2110       2120       2130       2140       2150
IIEFNDSDCF NAIEFINKRQ HIGKIVVNHN KENLIQELIK KTNLPIIKSN 
      2160       2170       2180       2190       2200
YQINSDHLGK NILVTGQSGI ILEILKWIVK YSTNVENIII LSRSSLKWEL 
      2210       2220       2230       2240       2250
ELLVNKNKNK LNFIYKSVDV GNSLEIEKVI DEILMENPQI NNVDSIFHYA 
      2260       2270       2280       2290       2300
FTQISCKEHE IDQVHLNVSH QAKTMGAINL HNQSIKRNWK LINFIMASSA 
      2310       2320       2330       2340       2350
AGLIGSTDQC SYVCSSNVLD TFSKYRKHVL GLPSICINYG LIESTGFVSR 
      2360       2370       2380       2390       2400
NQSVAVMLDG QGIRPMQTNQ ILGSLDLFIQ NPSKSTNIIL TSFNFNEFAT 
      2410       2420       2430       2440       2450
GNLQQSNVHK FDFQFNCCLS QKSKLMANNQ ASENPVKDLL INNICELLSI 
      2460       2470       2480       2490       2500
DESKLNIDIR LIDYGSDSLT IVQIKNLIDK NLLIPNLISI QMLQNNSISD 
      2510       2520       2530 
NIKILTDSYN KKKQNEQNEL KNIKVGSFTK K

Length:2,531

Mass (Da):287,781

Last modified:May 24, 2005 - v1

Checksum:ⁱ017B776B3C5E8124

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAFI02000111 Genomic DNA Translation: EAL63254.1
NCBI Reference Sequences More...RefSeqⁱ	XP_636757.1, XM_631665.1

Genome annotation databases

EnsemblProtistsⁱ	EAL63254; EAL63254; DDB_G0288457
GeneIDⁱ	8626635
KEGGⁱ	ddi:DDB_G0288457

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q54IX3	Probable polyketide synthase 9/36		DICDI		2931	UniRef50_Q86AE3
Uncharacterized protein		DICPU		2919
Probable polyketide synthase 6		DICDI		2924
Probable polyketide synthase 8/35		DICDI		2514
Probable polyketide synthase 7		DICDI		2513
+2

Entry informationⁱ

Entry nameⁱ	PKS26_DICDI
Accessionⁱ	Q54IX3Primary (citable) accession number: Q54IX3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
	Last sequence update:	May 24, 2005
	Last modified:	May 23, 2018
	This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - Q54IX3 (PKS26_DICDI)

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Probable polyketide synthase 26

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Functionⁱ

Miscellaneous

Cofactorⁱ

Sites

GO - Molecular functionⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Organism-specific databases

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q54IX3 (PKS26_DICDI)

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Probable polyketide synthase 26

pks26

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ