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UniProtKB - Q54I56 (SMC6_DICDI)

Entry version 88 (25 May 2022)
Sequence version 1 (24 May 2005)
Previous versions | rss
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Protein

Structural maintenance of chromosomes protein 6

Gene

smc6

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of the smc5-smc6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the smc1-smc3 cohesin complex to double-strand breaks (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi176 – 183ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA recombination, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DDI-3108214, SUMOylation of DNA damage response and repair proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 6
Short name:
SMC protein 6
Short name:
SMC-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:smc6
ORF Names:DDB_G0288993
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...dictyBasei		DDB_G0288993, smc6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003279301 – 1185Structural maintenance of chromosomes protein 6Add BLAST1185

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q54I56

PRoteomics IDEntifications database

More...PRIDEi		Q54I56

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with smc5.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		44689.DDB0231143

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q54I56

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q54I56

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 144DisorderedSequence analysisAdd BLAST144
Regioni571 – 807Flexible hingeAdd BLAST237

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili337 – 570Sequence analysisAdd BLAST234
Coiled coili808 – 1024Sequence analysisAdd BLAST217

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 31Acidic residuesSequence analysisAdd BLAST18
Compositional biasi32 – 46Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi47 – 74Polar residuesSequence analysisAdd BLAST28
Compositional biasi84 – 125Acidic residuesSequence analysisAdd BLAST42

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of smc5, forming a V-shaped heterodimer.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMC family. SMC6 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0250, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009063_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q54I56

Identification of Orthologs from Complete Genome Data

More...OMAi		MCHDHFY

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q54I56

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N
IPR027132, SMC6

The PANTHER Classification System

More...PANTHERi		PTHR19306:SF6, PTHR19306:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02463, SMC_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54I56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKRKLGHDG NSHELDEEEE EEEEDDDDEL IHSTQDQDRP HKQQRVENGK 
        60         70         80         90        100
QMTPTKQHQQ QQQQQPISNG RLKKLKAQSS DEESGSSEDD DEDVEDVDSS 
       110        120        130        140        150
GSDSGSSDDD DDDDDDDDDD DGNSEDEREA VRREQQLKSG VTEPEAGIIE 
       160        170        180        190        200
SITLENFMCH RHFKLDFCSN VNFIAGENGS GKSAVLIALI VCLGAKAGFT 
       210        220        230        240        250
NRGSKLSDLV KAETNTAVIT VKLRNQGQEA FKPEKYGKSV IIERRISRTG 
       260        270        280        290        300
SSGYKVKDYN GKTVSDKFND VSLILEQFNI QIDNPMSILT QDTSRQFLNS 
       310        320        330        340        350
AGPQDKYKSF LMATQLDKMT KDYTTIREHI DKIKDMLSQK VVVIQELEKK 
       360        370        380        390        400
VREYNKEYKD LQQMVGLERK ISEFKNQLAW SFVVESEREA KRKEKQVAEA 
       410        420        430        440        450
EERSFDNDIR KVDETIETYN KSIEDIKKDI KEFTDQIKIQ EQKKETNNRE 
       460        470        480        490        500
ILTIEREEAK IQTQIEANNK KRQQRKQRRH LQLQSINEIK ERNAQLANNQ 
       510        520        530        540        550
SKLDEIKKKG QQKLQLEARK EELIKEKEDL MRDRENLKRD HQNQRTITQQ 
       560        570        580        590        600
MNREYEGLRV QLNNLRSTQK GENQAYGKGM TDFLHKIEAS RRNFSKLPIG 
       610        620        630        640        650
PIGLSLKIKN ESWAFAIESA ISKATLRNFL VFSIPDGITL QKLGHQFGIK 
       660        670        680        690        700
VDYTKIPETT EVYKTVEHDE LDPSLATVLR VLDSPSHFII NFLIDTKKVE 
       710        720        730        740        750
QIGLGNDRKE IDSVLYTDRC PRGLSQFFDP QGNNYSKTKS GNPFYQAAKN 
       760        770        780        790        800
SGEATMLRVN SDAAIQRTQR DMESKLPALN QQKKIEQELS SDVQAIEHKI 
       810        820        830        840        850
SQNDQDQNQC SRKILQITNE IKSIEDTLVQ QTDDYSELEI GLASLDEEIK 
       860        870        880        890        900
SMDEEINIQK AQRTEVAAQK GPFAENNRAL DDQIDVLSNQ LGNIENNLRK 
       910        920        930        940        950
FNEGLRKLNN NKQALLQQQG RSAQERDQFK AEYQRILEIV KEKTDKATQI 
       960        970        980        990       1000
CERIEIPTNE TNTTLTNKII QYTKQLEKES RGKRSRTEAL KLFQDANNSL 
      1010       1020       1030       1040       1050
KEISEQRDNI EELATILERN LNERYKKWQR FRLSISRRSD QYFNIFLSKK 
      1060       1070       1080       1090       1100
GYTGSLTFDH QNGKLDINVE LQKALPSNQN GTAKGDTKGL SGGERSFSTV 
      1110       1120       1130       1140       1150
SLLLAFWENM ECPFRAMDEF DVFMDEVNRS ISINLLMSKA EENRSKQYIF 
      1160       1170       1180 
VTPLALNHIK TSEYVKVFRV RAPVRTGGDV TVETD
Length:1,185
Mass (Da):136,329
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE024B4D34E8CDED
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAFI02000129 Genomic DNA Translation: EAL62951.1

NCBI Reference Sequences

More...RefSeqi		XP_636454.1, XM_631362.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		EAL62951; EAL62951; DDB_G0288993

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8626906

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ddi:DDB_G0288993

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000129 Genomic DNA Translation: EAL62951.1
RefSeqiXP_636454.1, XM_631362.1

3D structure databases

AlphaFoldDBiQ54I56
SMRiQ54I56
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231143

Proteomic databases

PaxDbiQ54I56
PRIDEiQ54I56

Genome annotation databases

EnsemblProtistsiEAL62951; EAL62951; DDB_G0288993
GeneIDi8626906
KEGGiddi:DDB_G0288993

Organism-specific databases

dictyBaseiDDB_G0288993, smc6

Phylogenomic databases

eggNOGiKOG0250, Eukaryota
HOGENOMiCLU_009063_0_0_1
InParanoidiQ54I56
OMAiMCHDHFY
PhylomeDBiQ54I56

Enzyme and pathway databases

ReactomeiR-DDI-3108214, SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q54I56

Family and domain databases

Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N
IPR027132, SMC6
PANTHERiPTHR19306:SF6, PTHR19306:SF6, 1 hit
PfamiView protein in Pfam
PF02463, SMC_N, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMC6_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54I56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 25, 2022
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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