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Protein

Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

Gene

mmsdh

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).By similarity

Catalytic activityi

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.
3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei307NucleophilePROSITE-ProRule annotation1
Binding sitei408NADSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 203NADSequence analysis5
Nucleotide bindingi251 – 256NADSequence analysis6

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-DDI-70895 Branched-chain amino acid catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (EC:1.2.1.18, EC:1.2.1.27)
Short name:
MMSDH
Short name:
Malonate-semialdehyde dehydrogenase [acylating]
Gene namesi
Name:mmsdh
Synonyms:aldh6
ORF Names:DDB_G0289085
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0289085 mmsdh

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
ChainiPRO_000032792627 – 528Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialAdd BLAST502

Proteomic databases

PaxDbiQ54I10
PRIDEiQ54I10

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231483

Structurei

3D structure databases

ProteinModelPortaliQ54I10
SMRiQ54I10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2449 Eukaryota
ENOG410XNP1 LUCA
InParanoidiQ54I10
KOiK00140
OMAiSQWKEED
PhylomeDBiQ54I10

Family and domain databases

CDDicd07085 ALDH_F6_MMSDH, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR010061 MeMal-semiAld_DH
PANTHERiPTHR43866 PTHR43866, 1 hit
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01722 MMSDH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54I10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSFKFAKSA SKVIGNRNFH SSSASLANTT KLFINGKFVE SKTKEWLEVR
60 70 80 90 100
NPATQELVTK VPVSTKEEME AAVKAASDAF PAWRDTSVSN RSRIISNYKN
110 120 130 140 150
LINKNMDKIA AIITEEQGKT LPDAKGDVFR GLEVVEHSVN VASLMMGETV
160 170 180 190 200
ENVSKNVDIY SYVQPLGVCA GITPFNFPAM IPLWMFPLAI ACGNTFVLKP
210 220 230 240 250
SERVPSASMF LVQLAQEAGV PDGVVNVIHG GKEAVNFICD APEVRAISFV
260 270 280 290 300
GADQAGRHIH ARGTANGKRV QSNMAAKNHA TIVPDAHKER TLDALTGAAF
310 320 330 340 350
GASGQRCMAL SAAVFVGESK NWIPELAERA KKLKVAGGAA PGADLGPVIS
360 370 380 390 400
AASKQRIHEL IQSGIDEGAK CILDGRNVVV DPEFSKGNFV GPTILTDVKP
410 420 430 440 450
HMRCYKEEIF GPVLVCLNVD TVDQAIQLIN ANPYGNGTAV FTSSGAVARK
460 470 480 490 500
YQREIDVGQV GINLPIPVPL PFFSFTGSRG SFVGAGHFYG KTGVQFFTQI
510 520
KTITSNWRDD DISHGVSSSM NMPILGKN
Length:528
Mass (Da):56,696
Last modified:May 24, 2005 - v1
Checksum:iD83629D894CC3E68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000130 Genomic DNA Translation: EAL62892.1
RefSeqiXP_636395.1, XM_631303.1

Genome annotation databases

EnsemblProtistsiEAL62892; EAL62892; DDB_G0289085
GeneIDi8626954
KEGGiddi:DDB_G0289085

Similar proteinsi

Entry informationi

Entry nameiMMSA_DICDI
AccessioniPrimary (citable) accession number: Q54I10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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