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Protein

Elongation factor Tu, mitochondrial

Gene

tufm

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 52GTPBy similarity8
Nucleotide bindingi107 – 111GTPBy similarity5
Nucleotide bindingi162 – 165GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu, mitochondrial
Gene namesi
Name:tufm
ORF Names:DDB_G0289593
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0289593 tufM

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000328177? – 424Elongation factor Tu, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ54HB2
PRIDEiQ54HB2

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0235257

Structurei

3D structure databases

ProteinModelPortaliQ54HB2
SMRiQ54HB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 234tr-type GAdd BLAST199

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 52G1By similarity8
Regioni86 – 90G2By similarity5
Regioni107 – 110G3By similarity4
Regioni162 – 165G4By similarity4
Regioni199 – 201G5By similarity3

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0460 Eukaryota
COG0050 LUCA
InParanoidiQ54HB2
OMAiYGHIDCP
PhylomeDBiQ54HB2

Family and domain databases

CDDicd03697 EFTU_II, 1 hit
HAMAPiMF_00118_B EF_Tu_B, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR033720 EFTU_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004541 Transl_elong_EFTu/EF1A_bac/org
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00485 EF-Tu, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54HB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISRLFASNQ NVKLVRTFKS TSISMAAEKK KFERTKPHVN VGTIGHVDHG
60 70 80 90 100
KTTLTAAITK TLSDRGLANF KSYAQIDKSP EEKARGITIT ASHIEYESAT
110 120 130 140 150
RHYAHIDCPG HQHYIKNMIT GAAQMDGAIL VVSAPDGPQE QTREHIILSR
160 170 180 190 200
EVGIPALVVF LNKMDNADPD LVEIVEMEVR ELLSQYGFNG DETPFVKGAA
210 220 230 240 250
AVALAETNET ATQYGRKAID ELVEVLDTKI PLPHRAVDKP FLMPVEEVFS
260 270 280 290 300
ISGRGTVATG RIEQGTLKVG EEVAIVGIKP VPKVAVTGIE MFGKLLDFAQ
310 320 330 340 350
AGENVGCLLR GLKREEVLRG EVISKPGTIK ASTKFKAKTY VLTEAEGGRK
360 370 380 390 400
KGFATGYRPQ FFIRTANVTG MIELPPTHAV ILPGDSLEFT VELISPTPLS
410 420
INGRFAIREG QLTVGAGVIS EILN
Length:424
Mass (Da):46,026
Last modified:March 18, 2008 - v2
Checksum:i5FDCB971E615F2F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000146 Genomic DNA Translation: EAL62650.2
RefSeqiXP_636148.2, XM_631056.2

Genome annotation databases

EnsemblProtistsiEAL62650; EAL62650; DDB_G0289593
GeneIDi8627215
KEGGiddi:DDB_G0289593

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000146 Genomic DNA Translation: EAL62650.2
RefSeqiXP_636148.2, XM_631056.2

3D structure databases

ProteinModelPortaliQ54HB2
SMRiQ54HB2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0235257

Proteomic databases

PaxDbiQ54HB2
PRIDEiQ54HB2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL62650; EAL62650; DDB_G0289593
GeneIDi8627215
KEGGiddi:DDB_G0289593

Organism-specific databases

dictyBaseiDDB_G0289593 tufM

Phylogenomic databases

eggNOGiKOG0460 Eukaryota
COG0050 LUCA
InParanoidiQ54HB2
OMAiYGHIDCP
PhylomeDBiQ54HB2

Miscellaneous databases

PROiPR:Q54HB2

Family and domain databases

CDDicd03697 EFTU_II, 1 hit
HAMAPiMF_00118_B EF_Tu_B, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR033720 EFTU_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004541 Transl_elong_EFTu/EF1A_bac/org
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00485 EF-Tu, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEFTU_DICDI
AccessioniPrimary (citable) accession number: Q54HB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 18, 2008
Last modified: February 28, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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