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Entry version 90 (16 Oct 2019)
Sequence version 1 (24 May 2005)
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Protein
Submitted name:

RNA-directed RNA polymerase

Gene

rrpA

Organism
Dictyostelium discoideum (Slime mold)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymeraseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RNA-directed RNA polymeraseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rrpAImported
ORF Names:DDB0191515Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0289659 rrpA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54H25

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0191515

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini291 – 468Helicase ATP-bindingInterPro annotationAdd BLAST178
Domaini633 – 799Helicase C-terminalInterPro annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni193 – 253DisorderedSequence analysisAdd BLAST61
Regioni2112 – 2154DisorderedSequence analysisAdd BLAST43
Regioni2210 – 2230DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi193 – 250PolarSequence analysisAdd BLAST58

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0701 Eukaryota
KOG0988 Eukaryota
COG1111 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54H25

Identification of Orthologs from Complete Genome Data

More...
OMAi
FDEETIM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54H25

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR007855 RNA-dep_RNA_pol_euk-typ

The PANTHER Classification System

More...
PANTHERi
PTHR23079 PTHR23079, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271 Helicase_C, 1 hit
PF05183 RdRP, 1 hit
PF04851 ResIII, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54H25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVDSKSKEI EQYDQWLYCS NCLNGVLEYK HLGFYIDMEG VYLEVLRDSS
60 70 80 90 100
SIFNNNHFYD HNYRDGADII DQLPNIDRYH LVSKSLQQQY STTVNDNSYY
110 120 130 140 150
MFDSRKHDLL VQKPYLMCSY KECYNIIGFY HMNPFKKVFS FRLDHAKTIL
160 170 180 190 200
DFGYEDKPWK FFLNNPIFEK IQVYKNQDID YYGFNSINKK YNNNNDNNNN
210 220 230 240 250
FNNNNNNNNN NNKNNNNNNN NNNNNNNNNN NNNNNSLNSL FKNNDNSNKF
260 270 280 290 300
QPRMETKDVH YKPTKLPQEK PMIPKFKEGV EIIPRDYQIE SYYQSTQDNT
310 320 330 340 350
LLVLPTGMGK TLVSIMTLLE MFSINDQDNS CGDSKRIALF LVDRVPLVTQ
360 370 380 390 400
QAGAIEAITN LKVCKLYGEI NDSRTRAFVR SKEYDVLVST VGSLVNLLEV
410 420 430 440 450
RHLNILDFYF ITFDEVHHAT GEHDFNKVVD YIRKTDLNYR PRILGLTASL
460 470 480 490 500
VSIGNSTIDI VQRSIKDMEE RMLSRVFKPT SLLTNSTQSE LQPELVSFKT
510 520 530 540 550
SGQESLIETS ICEFLVSNSK ELQIFLNYSD VDLDGVRGNP SFLKALERLD
560 570 580 590 600
KYSKQLESIY IEYTKVLIEL YALLSVLSTE GPKQVLTRLD LLMQSTNQEN
610 620 630 640 650
ELYNKLLELR YYISGQYEDR ESNFEKGSTR YRKLISSLEY AISDASDGEL
660 670 680 690 700
QKDLRILVFV ETRFGASNLT SMLKKEPFQE YLHTKRLVGH NGVDGMDSEK
710 720 730 740 750
QQSIIRKFRD GKCRLIVTTN VLEEGIDVQD CNIVICYDGI LSLKSLIQRR
760 770 780 790 800
GRARSKNESK FIIIYNDDKD LKILDILSSE NLLNNSINQI LSNRERQAIT
810 820 830 840 850
KNQFLNWKKL NINNEYFTNN QLDGGPLDKD IKCVILSIYH IEIDIETFRE
860 870 880 890 900
LLLFQLPDII NQVDQVSIRM EGDDEYLSSY IIVILNTCID KEQSIYRLKS
910 920 930 940 950
LLNINGLKYW MIDRSSFHFE DDNINDLSQS KNKNYSIRSF EYGNMSSPTK
960 970 980 990 1000
YHGIGQLDDS FELFYGKREM FFTKKTRFQR YRLNLKLTDI ESTFLLVNDK
1010 1020 1030 1040 1050
YQNIVHILLI VKRPLIFEEE KKTHIVFWNK SKPKKDDFGQ AFVYRLTLST
1060 1070 1080 1090 1100
IDNEIKEVIK PLIANGFRMY ESSLELNCFI QGGINKNNNC MIIDLNLQYI
1110 1120 1130 1140 1150
KRNLEIHYLL QCLQSQSSYG RVLNQDFIVE INNLLAFGKQ EEAEFIITSL
1160 1170 1180 1190 1200
ISKRTKFINY KEFIGDCLKN FLPDPYYAKK KDLSTKSGEF TMIRDVFITP
1210 1220 1230 1240 1250
SRTIFIQPTL QRSCRAVRKF GSSNFIVVKI VNESLEPLQG VNNKHPLHEN
1260 1270 1280 1290 1300
RIKPILEGGI LVGGEIYSYA GNSNSQLREY SSWFVSNQIG THTVKIWSGI
1310 1320 1330 1340 1350
EHVDNVRKFF RCIGLMFSTT IPTVTLPQNR IYRIQDITRN THEFTEGCGE
1360 1370 1380 1390 1400
IGPELAKHLN ENYNFRPSTC AYQVRIGGNK GVLVVNNQAP DPSGIYIRPS
1410 1420 1430 1440 1450
MVKFNPIDCG DEHRTLEICS VSTTSRCKLN RQVISLLSTL GTQDNVFFAL
1460 1470 1480 1490 1500
QDHYLNQVAQ IVNDTNASKQ AIVEFFPDIT EGELYQDPYI RRILISLYKL
1510 1520 1530 1540 1550
KMERIQQKCH IEIKDSRMLL GVCDPTNSLP PNTVFVQLEE EDEDDDDDGR
1560 1570 1580 1590 1600
KYEKVIEGLV MVIKNPCTHP GDVRYLKAVD NIRLRHLRNV LVFSTKGDVP
1610 1620 1630 1640 1650
NFKEISGSDL DGDRYFFCYD KSLIGNRSES ETAYLVVETV SNNDKKANVF
1660 1670 1680 1690 1700
NDPFALSSMY STNAERQELG KLYHSHLAIS DQYGANHKYS IQISKECFKE
1710 1720 1730 1740 1750
IDYPKTGIHG TIPKEVNIRL QTVGYPHYMQ RENSTRVYYQ SKKIMGKMYD
1760 1770 1780 1790 1800
QIDQLVYIGD FLPNISLDKS NLVDGYEIYL NSAKILYSQY KLQVHSLLRH
1810 1820 1830 1840 1850
YSAESEESIM IGFLDQGFIS DKVSKDIKGE MKNDYIKIQQ TFENEFLKEF
1860 1870 1880 1890 1900
GEQHKENCLL IHRVNIEKKV SAWYHVAYSD LKDDRALGFY WIARSFKQMT
1910 1920 1930 1940 1950
LDQESQKKKN ILVNSILDHM NKKKDTLFPL YESRLLIVKE LTSFLNTLND
1960 1970 1980 1990 2000
TVFKESTLEI IGSTATMLFD ENSNLNLYLK LENQNDHMNL AEKNEILNQL
2010 2020 2030 2040 2050
KDEIKTSSFI SAEACSIIKI QGDIPLFKFK IDKIQCLIGL ETSKWYETLV
2060 2070 2080 2090 2100
QQQYITKNPS ILSILFSIID WSINSLFVDS ETGEIINNSK VYSSLNLQKV
2110 2120 2130 2140 2150
IVENSMIPSI FNNKNHNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
2160 2170 2180 2190 2200
KHSVKNLTKS NLFSLLIDFC IINKYIDKCN PNELTNTTSN LTIGNWVKLI
2210 2220 2230 2240 2250
EIASRYFSVD NNNNNNNKGH KRKKNKNLDE YNTNNLGDTI LSFFRFYSDS
2260 2270 2280 2290 2300
FGRSIYGNEP FIIKLFSKDA NDIENQILNP STESHKTALL FYQESFRHAF
2310 2320 2330 2340 2350
HSLSTFVSVE EFLSNCLKTT KKIMPIKKNQ INLLQERSVN EEIVKNVQLC
2360 2370 2380 2390 2400
GCSIKIDTNV KNPYILIDGK PQQIRLAQNA IRDLLSIKTE NYNLAITKRN
2410
NKRKNFTLGD FAKNKIK
Length:2,417
Mass (Da):280,223
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6FE7E0FF2E135DA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI01000219 Genomic DNA Translation: EAL62541.1

NCBI Reference Sequences

More...
RefSeqi
XP_636093.1, XM_631001.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8627305

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0289659

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI01000219 Genomic DNA Translation: EAL62541.1
RefSeqiXP_636093.1, XM_631001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0191515

Proteomic databases

PaxDbiQ54H25

Genome annotation databases

GeneIDi8627305
KEGGiddi:DDB_G0289659

Organism-specific databases

dictyBaseiDDB_G0289659 rrpA

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
KOG0988 Eukaryota
COG1111 LUCA
InParanoidiQ54H25
OMAiFDEETIM
PhylomeDBiQ54H25

Family and domain databases

InterProiView protein in InterPro
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR007855 RNA-dep_RNA_pol_euk-typ
PANTHERiPTHR23079 PTHR23079, 3 hits
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF05183 RdRP, 1 hit
PF04851 ResIII, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ54H25_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54H25
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 16, 2019
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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