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UniProtKB - Q54GC1 (DGAT2_DICDI)
Protein
Diacylglycerol O-acyltransferase 2
Gene
dgat2
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis (By similarity).
By similarityCatalytic activityi
- EC:2.3.1.20By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:2.3.1.76By similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
: triacylglycerol biosynthesis Pathwayi
This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.
GO - Molecular functioni
- diacylglycerol O-acyltransferase activity Source: dictyBase
- retinol O-fatty-acyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- diacylglycerol biosynthetic process Source: UniProtKB
- glycerol metabolic process Source: UniProtKB-KW
- lipid metabolic process Source: GO_Central
- monoacylglycerol biosynthetic process Source: UniProtKB
- triglyceride biosynthetic process Source: dictyBase
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Glycerol metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
Reactomei | R-DDI-1482883, Acyl chain remodeling of DAG and TAG R-DDI-2142753, Arachidonic acid metabolism R-DDI-2187335, The retinoid cycle in cones (daylight vision) R-DDI-75109, Triglyceride biosynthesis R-DDI-9640463, Wax biosynthesis |
UniPathwayi | UPA00282 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:dgat2 ORF Names:DDB_G0290279 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0290279, dgat2 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
- perinuclear endoplasmic reticulum membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- lipid droplet Source: dictyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 15 – 35 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 37 – 57 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328257 | 1 – 330 | Diacylglycerol O-acyltransferase 2Add BLAST | 330 |
Proteomic databases
PaxDbi | Q54GC1 |
Structurei
3D structure databases
AlphaFoldDBi | Q54GC1 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the diacylglycerol acyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0831, Eukaryota |
HOGENOMi | CLU_023995_0_1_1 |
InParanoidi | Q54GC1 |
OMAi | PFYRDYI |
PhylomeDBi | Q54GC1 |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54GC1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRFVPWNVP LYRRLETMAV AIYAMVLPVC LIMAFNLIVI PLFWGIAIPY
60 70 80 90 100
LVWMFYFDTK HESGGRRVSL VRNSILWRYF RDYFPISLII NSNYDPKKNY
110 120 130 140 150
IFAYHPHGII SIGAFCNFAT NANNIDEKLP GLKVHLLTLE SNFKIPFLRD
160 170 180 190 200
VLMSFGMSSV SKKSCENILN SGAGESICLV VGGAEESLDA RPGLNEITLK
210 220 230 240 250
KRKGFIKLAL VNGASLVPVY SFGENDIYDQ VPNPRGSLVR KIQTKIKDLT
260 270 280 290 300
GIAPPLFMGR GIFNYDFGLL PVRHKIVTVV GEPIDIPKIK SPTDQVIEHY
310 320 330
HQIYVEALQN LFDKHKNSCA DKETGNLKIN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000162 Genomic DNA Translation: EAL62266.1 |
RefSeqi | XP_635762.1, XM_630670.1 |
Genome annotation databases
EnsemblProtistsi | EAL62266; EAL62266; DDB_G0290279 |
GeneIDi | 8627566 |
KEGGi | ddi:DDB_G0290279 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000162 Genomic DNA Translation: EAL62266.1 |
RefSeqi | XP_635762.1, XM_630670.1 |
3D structure databases
AlphaFoldDBi | Q54GC1 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 44689.DDB0233097 |
Proteomic databases
PaxDbi | Q54GC1 |
Genome annotation databases
EnsemblProtistsi | EAL62266; EAL62266; DDB_G0290279 |
GeneIDi | 8627566 |
KEGGi | ddi:DDB_G0290279 |
Organism-specific databases
dictyBasei | DDB_G0290279, dgat2 |
Phylogenomic databases
eggNOGi | KOG0831, Eukaryota |
HOGENOMi | CLU_023995_0_1_1 |
InParanoidi | Q54GC1 |
OMAi | PFYRDYI |
PhylomeDBi | Q54GC1 |
Enzyme and pathway databases
UniPathwayi | UPA00282 |
Reactomei | R-DDI-1482883, Acyl chain remodeling of DAG and TAG R-DDI-2142753, Arachidonic acid metabolism R-DDI-2187335, The retinoid cycle in cones (daylight vision) R-DDI-75109, Triglyceride biosynthesis R-DDI-9640463, Wax biosynthesis |
Miscellaneous databases
PROi | PR:Q54GC1 |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DGAT2_DICDI | |
Accessioni | Q54GC1Primary (citable) accession number: Q54GC1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families