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Protein

FK506-binding protein 5

Gene

fkbp5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PPIases accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by both FK506 and rapamycin.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Rotamase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FK506-binding protein 5 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fkbp5
ORF Names:DDB_G0290433
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0290433

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003312841 – 1622FK506-binding protein 5Add BLAST1622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei314Omega-N-methylarginine1 Publication1

Keywords - PTMi

Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54G21

PRoteomics IDEntifications database

More...
PRIDEi
Q54G21

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0233865

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q54G21

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54G21

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini178 – 269PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili607 – 827Sequence analysisAdd BLAST221
Coiled coili854 – 961Sequence analysisAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 8Poly-Glu4
Compositional biasi348 – 403Poly-AsnAdd BLAST56
Compositional biasi406 – 412Poly-Asn7
Compositional biasi415 – 428Poly-AsnAdd BLAST14
Compositional biasi519 – 522Poly-Pro4
Compositional biasi527 – 540Poly-ProAdd BLAST14
Compositional biasi1049 – 1054Poly-Glu6
Compositional biasi1057 – 1094Poly-GluAdd BLAST38
Compositional biasi1152 – 1165Poly-AspAdd BLAST14
Compositional biasi1191 – 1194Poly-Asp4
Compositional biasi1195 – 1202Poly-Glu8
Compositional biasi1221 – 1230Poly-Glu10
Compositional biasi1239 – 1246Poly-Glu8
Compositional biasi1305 – 1309Poly-Glu5
Compositional biasi1347 – 1354Poly-Glu8
Compositional biasi1395 – 1399Poly-Glu5
Compositional biasi1430 – 1433Poly-Glu4
Compositional biasi1440 – 1446Poly-Thr7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0543 Eukaryota
COG0545 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54G21

KEGG Orthology (KO)

More...
KOi
K17478

Identification of Orthologs from Complete Genome Data

More...
OMAi
TEDIMST

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54G21

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001179 PPIase_FKBP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00254 FKBP_C, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54G21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFSEEEEYS NRNAASSQKL GSLFKDNNAM SGNQSLQYTN NKTQSSANSN
60 70 80 90 100
SPDVLISFPI HLYKFDNNKN EYVSSGSIAT AIVGYKSSGK YQLLAYDNNK
110 120 130 140 150
NYIVTVNITA QFNYSVTTIY GSFTDGNGQN WSMTFNSAEE STKYATHVAI
160 170 180 190 200
AKCASGGYQQ ITFVDINNQS KTKPVANGDR VSIKYAGWLE NNQRVGSLFD
210 220 230 240 250
SNLQSETPFR FVVGEGKVIK GWDLGVIGMR KSAKRILVIP SELAYGKKGH
260 270 280 290 300
STIPPNTNLI FDLEVTGSKK KEGSEPSLPS LNGQPSNAPQ QSLPTQLFDN
310 320 330 340 350
SPVPQDDKAN LLQRVAKLGR ATGFTSPPPS DSENESNSRN SHSNNSHNNN
360 370 380 390 400
NNNNSNSNNN SNSNSNNNNN NNNQNNNNNN NNQNNNQNNN NNNNYNNNNN
410 420 430 440 450
NNNGYNNNNN NNGYNNNNNY NNNMNNNNGF NNGMNNGFGN NSMNGMNNGF
460 470 480 490 500
NNGMNGMNNG MNGGFGMNGN MYTSSQSPQF NPMGTFGSAY NQQQALIGSG
510 520 530 540 550
ALVPIMPQHQ QPSIIVASPP PPVQQAPPPT PAPAPPPPTP VIVQAPPAPV
560 570 580 590 600
QSTTETIQIL VEEKQFKKEI KHSIDQFNSK LDQVSSKFDS LAQPIVKGDV
610 620 630 640 650
PISGVLLVQT LHRLVEDNEK LIKENVEKEN RMVTLKENIA TLHKKNEQFL
660 670 680 690 700
EENTKMMESR NEAITDNVAQ MRRQIIDLQK QKTLVEDDLA DKQMLHTKSQ
710 720 730 740 750
SVINQLKRDY NTLQEELNSA KEENQKSIQD QEALKQAEKD YALKIRAFKK
760 770 780 790 800
SLLDEKNARK SDIEKINSLE DELKDAQDSL TQAEKSNEES LKRLKLDMVR
810 820 830 840 850
IKKRNDDKVS QLTLEITTLK DTLETERSAL SSVQTLVENT RLETESKFNL
860 870 880 890 900
LLIKKEEAIA AAELSLSEEQ SKYNKLVQSN NQQIDQLQKL IDDAKKKLDH
910 920 930 940 950
EKEEVIKSYK KGFAEGIEST KQENDLITTL QQQIQQLTTQ YDDTKKSLIE
960 970 980 990 1000
TKEKLSTLES QPPKTIVKEV IVKVPSDGTT VAVASSNNVD VAKEVKVCMQ
1010 1020 1030 1040 1050
KVFVQVSESF DEDEEYSTDS IMSTFKDVIK RVTVEYIQEQ KEKQQQQQEK
1060 1070 1080 1090 1100
EEEEVVEEEE KEEEEKEEEE KEEEEKEEEK EEEKEQEEEE EEKEVVVEEI
1110 1120 1130 1140 1150
VTIAEEVKEE EVVVEEPVTV VEEVKEEKPT PAIEEPVVAK SQTVVDPLST
1160 1170 1180 1190 1200
KDDEDDDDDE DDYDDINEED LKNIDAEIEK MQQEMGDELE DDDDEEEEKE
1210 1220 1230 1240 1250
KETAPVVTKS EVVDPLSSTK EESEEEEEEE TKVEVPVLEE EKEEEETKVE
1260 1270 1280 1290 1300
VPVLEDEQED KVESDVEEKI VEPPTLDEDD FEKVEVPVLG DDEQDEKVVE
1310 1320 1330 1340 1350
EPAPEEEEET KVEVPVLNKD DDEDNEKDVA SDSEETPSTP PPIDDVEEEE
1360 1370 1380 1390 1400
EKEEKVVEQV KEEINETKFE SSPFAVDEPT TTEEKEEEKE EEKVEEEEEK
1410 1420 1430 1440 1450
VVEPPTIDDD ETTAPVIPSI DNSPRQTTTE EEESSTTAAT TSTTTTSSTP
1460 1470 1480 1490 1500
VKPDEADTTK KTPKKTSFFD FDDSPFSAET ETETKSTAAS SDPFADTTSS
1510 1520 1530 1540 1550
TPTSTKKKDF FSTDDDSLFG NSSDIFDKPS TTTKKDPFDT DSTDDLFGSI
1560 1570 1580 1590 1600
KTNKESTSTA SSTSNGGLFD SDSLFGGISV AKSNNNTPSR QKQDFSSLFG
1610 1620
SDPTISPLTE TEPEEKEIVL PL
Length:1,622
Mass (Da):181,595
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD573095ABECAA4C1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000163 Genomic DNA Translation: EAL62232.1

NCBI Reference Sequences

More...
RefSeqi
XP_635751.1, XM_630659.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL62232; EAL62232; DDB_G0290433

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8627670

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0290433

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000163 Genomic DNA Translation: EAL62232.1
RefSeqiXP_635751.1, XM_630659.1

3D structure databases

ProteinModelPortaliQ54G21
SMRiQ54G21
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0233865

Proteomic databases

PaxDbiQ54G21
PRIDEiQ54G21

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL62232; EAL62232; DDB_G0290433
GeneIDi8627670
KEGGiddi:DDB_G0290433

Organism-specific databases

dictyBaseiDDB_G0290433

Phylogenomic databases

eggNOGiKOG0543 Eukaryota
COG0545 LUCA
InParanoidiQ54G21
KOiK17478
OMAiTEDIMST
PhylomeDBiQ54G21

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54G21

Family and domain databases

InterProiView protein in InterPro
IPR001179 PPIase_FKBP_dom
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFKBP5_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54G21
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: December 5, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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