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Protein

FK506-binding protein 5

Gene

fkbp5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein 5 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:fkbp5
ORF Names:DDB_G0290433
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290433

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312841 – 1622FK506-binding protein 5Add BLAST1622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei314Omega-N-methylarginine1 Publication1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ54G21
PRIDEiQ54G21

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0233865

Structurei

3D structure databases

ProteinModelPortaliQ54G21
SMRiQ54G21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 269PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili607 – 827Sequence analysisAdd BLAST221
Coiled coili854 – 961Sequence analysisAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 8Poly-Glu4
Compositional biasi348 – 403Poly-AsnAdd BLAST56
Compositional biasi406 – 412Poly-Asn7
Compositional biasi415 – 428Poly-AsnAdd BLAST14
Compositional biasi519 – 522Poly-Pro4
Compositional biasi527 – 540Poly-ProAdd BLAST14
Compositional biasi1049 – 1054Poly-Glu6
Compositional biasi1057 – 1094Poly-GluAdd BLAST38
Compositional biasi1152 – 1165Poly-AspAdd BLAST14
Compositional biasi1191 – 1194Poly-Asp4
Compositional biasi1195 – 1202Poly-Glu8
Compositional biasi1221 – 1230Poly-Glu10
Compositional biasi1239 – 1246Poly-Glu8
Compositional biasi1305 – 1309Poly-Glu5
Compositional biasi1347 – 1354Poly-Glu8
Compositional biasi1395 – 1399Poly-Glu5
Compositional biasi1430 – 1433Poly-Glu4
Compositional biasi1440 – 1446Poly-Thr7

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0543 Eukaryota
COG0545 LUCA
InParanoidiQ54G21
KOiK17478
OMAiTEDIMST
PhylomeDBiQ54G21

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR43811 PTHR43811, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q54G21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFSEEEEYS NRNAASSQKL GSLFKDNNAM SGNQSLQYTN NKTQSSANSN
60 70 80 90 100
SPDVLISFPI HLYKFDNNKN EYVSSGSIAT AIVGYKSSGK YQLLAYDNNK
110 120 130 140 150
NYIVTVNITA QFNYSVTTIY GSFTDGNGQN WSMTFNSAEE STKYATHVAI
160 170 180 190 200
AKCASGGYQQ ITFVDINNQS KTKPVANGDR VSIKYAGWLE NNQRVGSLFD
210 220 230 240 250
SNLQSETPFR FVVGEGKVIK GWDLGVIGMR KSAKRILVIP SELAYGKKGH
260 270 280 290 300
STIPPNTNLI FDLEVTGSKK KEGSEPSLPS LNGQPSNAPQ QSLPTQLFDN
310 320 330 340 350
SPVPQDDKAN LLQRVAKLGR ATGFTSPPPS DSENESNSRN SHSNNSHNNN
360 370 380 390 400
NNNNSNSNNN SNSNSNNNNN NNNQNNNNNN NNQNNNQNNN NNNNYNNNNN
410 420 430 440 450
NNNGYNNNNN NNGYNNNNNY NNNMNNNNGF NNGMNNGFGN NSMNGMNNGF
460 470 480 490 500
NNGMNGMNNG MNGGFGMNGN MYTSSQSPQF NPMGTFGSAY NQQQALIGSG
510 520 530 540 550
ALVPIMPQHQ QPSIIVASPP PPVQQAPPPT PAPAPPPPTP VIVQAPPAPV
560 570 580 590 600
QSTTETIQIL VEEKQFKKEI KHSIDQFNSK LDQVSSKFDS LAQPIVKGDV
610 620 630 640 650
PISGVLLVQT LHRLVEDNEK LIKENVEKEN RMVTLKENIA TLHKKNEQFL
660 670 680 690 700
EENTKMMESR NEAITDNVAQ MRRQIIDLQK QKTLVEDDLA DKQMLHTKSQ
710 720 730 740 750
SVINQLKRDY NTLQEELNSA KEENQKSIQD QEALKQAEKD YALKIRAFKK
760 770 780 790 800
SLLDEKNARK SDIEKINSLE DELKDAQDSL TQAEKSNEES LKRLKLDMVR
810 820 830 840 850
IKKRNDDKVS QLTLEITTLK DTLETERSAL SSVQTLVENT RLETESKFNL
860 870 880 890 900
LLIKKEEAIA AAELSLSEEQ SKYNKLVQSN NQQIDQLQKL IDDAKKKLDH
910 920 930 940 950
EKEEVIKSYK KGFAEGIEST KQENDLITTL QQQIQQLTTQ YDDTKKSLIE
960 970 980 990 1000
TKEKLSTLES QPPKTIVKEV IVKVPSDGTT VAVASSNNVD VAKEVKVCMQ
1010 1020 1030 1040 1050
KVFVQVSESF DEDEEYSTDS IMSTFKDVIK RVTVEYIQEQ KEKQQQQQEK
1060 1070 1080 1090 1100
EEEEVVEEEE KEEEEKEEEE KEEEEKEEEK EEEKEQEEEE EEKEVVVEEI
1110 1120 1130 1140 1150
VTIAEEVKEE EVVVEEPVTV VEEVKEEKPT PAIEEPVVAK SQTVVDPLST
1160 1170 1180 1190 1200
KDDEDDDDDE DDYDDINEED LKNIDAEIEK MQQEMGDELE DDDDEEEEKE
1210 1220 1230 1240 1250
KETAPVVTKS EVVDPLSSTK EESEEEEEEE TKVEVPVLEE EKEEEETKVE
1260 1270 1280 1290 1300
VPVLEDEQED KVESDVEEKI VEPPTLDEDD FEKVEVPVLG DDEQDEKVVE
1310 1320 1330 1340 1350
EPAPEEEEET KVEVPVLNKD DDEDNEKDVA SDSEETPSTP PPIDDVEEEE
1360 1370 1380 1390 1400
EKEEKVVEQV KEEINETKFE SSPFAVDEPT TTEEKEEEKE EEKVEEEEEK
1410 1420 1430 1440 1450
VVEPPTIDDD ETTAPVIPSI DNSPRQTTTE EEESSTTAAT TSTTTTSSTP
1460 1470 1480 1490 1500
VKPDEADTTK KTPKKTSFFD FDDSPFSAET ETETKSTAAS SDPFADTTSS
1510 1520 1530 1540 1550
TPTSTKKKDF FSTDDDSLFG NSSDIFDKPS TTTKKDPFDT DSTDDLFGSI
1560 1570 1580 1590 1600
KTNKESTSTA SSTSNGGLFD SDSLFGGISV AKSNNNTPSR QKQDFSSLFG
1610 1620
SDPTISPLTE TEPEEKEIVL PL
Length:1,622
Mass (Da):181,595
Last modified:May 24, 2005 - v1
Checksum:iD573095ABECAA4C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000163 Genomic DNA Translation: EAL62232.1
RefSeqiXP_635751.1, XM_630659.1

Genome annotation databases

EnsemblProtistsiEAL62232; EAL62232; DDB_G0290433
GeneIDi8627670
KEGGiddi:DDB_G0290433

Entry informationi

Entry nameiFKBP5_DICDI
AccessioniPrimary (citable) accession number: Q54G21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: July 18, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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