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UniProtKB - Q54FQ1 (PKS31_DICDI)
Protein
Probable polyketide synthase 31
Gene
pks31
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes and clustered as a quartet pks29/pks30/pks31/pks32 in chromosome 5.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 199 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 676 | For acyl/malonyl transferase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- oxidoreductase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pks31 ORF Names:DDB_G0290703 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0290703, pks31 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000371391 | 1 – 2623 | Probable polyketide synthase 31Add BLAST | 2623 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2561 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | Q54FQ1 |
PRIDEi | Q54FQ1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2524 – 2601 | CarrierPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 180 – 233 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 666 – 699 | Acyl/malonyl transferaseAdd BLAST | 34 | |
Regioni | 2600 – 2623 | DisorderedSequence analysisAdd BLAST | 24 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_5_1 |
InParanoidi | Q54FQ1 |
OMAi | AFYHPDH |
PhylomeDBi | Q54FQ1 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54FQ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQNIDNNNN KLIRDRNDDD DVDRNDDGDV AVIGIGLRFP SGNLKESISK
60 70 80 90 100
PNQLFNELLN GLDGIVSTSE RWSDNYYLNG EIVSKFAGLL PLDEWKQFDP
110 120 130 140 150
IFFAINQTYD NVSSIDPQQR LLLKCVWEAL EDSGIDPISL RGTNTSTFIG
160 170 180 190 200
NSTIDYYNLQ RSPSETQNNI FGSSTHSIAN RIGYCFDFRG ENLTIDTACS
210 220 230 240 250
SSSNAINCGY NSIKTNRSNV SIVGGVNIIL DPHISKSFTQ LDMLSPTGKC
260 270 280 290 300
HTFSSDADGF VRSEGVGIVV LKKLKDAIKD SNNIYCVIKG SSSNIDGNFD
310 320 330 340 350
KLNFYSPSKS SQCENIKLAI KSTNGQINES DIDYCETHGT GTPTGDPIEL
360 370 380 390 400
EGISRVFNSA KIPSTTINNN KQVLVGSIKS NIGHLEACSG VASLIKCCLM
410 420 430 440 450
FKNKLFLQNI NFKEPNPLIN FKEWGLKVVT EPIKFNENKS TVMLVNNFGI
460 470 480 490 500
TGSNVCLILS ELKKNHHNRY ENEYHKIEID SKVNEKKKYL IPLSSNSSTS
510 520 530 540 550
LNNYKSSIIK LSNSNSSPTT TTSFKELVHN QIKFKSTSLI QKSVIIASDW
560 570 580 590 600
NEFQDENNQI KLENSDNLIS NITVEKKKSP ITVMVLCGQG SQYNKMALSL
610 620 630 640 650
YDNEPIFRES VNRFDKELFK YYGYSVLDKL RSIDDKDLIS IHQPILAQPA
660 670 680 690 700
NVIIQVSLYE LYKHWGVSAD IIIGHSLGEV SSPYCSGMID FQTLCYLIYH
710 720 730 740 750
RSVAQNRTTG TGRMLSVNIS SDEFINNYQS TTKYESLEIA CYNSPTSIVI
760 770 780 790 800
AGREDLLNEI TNEFKSNNIF CTMLGLLSSF HTSSQQMIKD EVCSLNISSK
810 820 830 840 850
QPSIAVFSTV TTNLFNHQSL PFNADYAFEN IRQPVRFTQT ITNLYKHIES
860 870 880 890 900
NDMGNEITFI EVSPHPTLQY YLNQMKSTQS SYFNNGKNIT IYSPLNKKKN
910 920 930 940 950
DYNEFLKTIS LLYVNNNFDI NFKSQLINDN NNISNTTKLN NLPLYQWDDK
960 970 980 990 1000
EYFKIASFHE KIKSEGPSIH SLGNNTDSPY PSYQTFIDIK KSPFQWLKGH
1010 1020 1030 1040 1050
QVSDKFYYPG MGYVHNLLSI YPNQDITISS LEFKSPLVLT EGNNQCLQTT
1060 1070 1080 1090 1100
IAPLSKNEFN IKSHYKDQKT NQWILSSLGN FNLTKHNSII SNKLINIQSL
1110 1120 1130 1140 1150
KDKCNFTSIS KQDFYETIRI KTNLTYKGLF QGVKQCYIGN NCSLSIVSLN
1160 1170 1180 1190 1200
EIYNQKEYNH LINNSNMNKF LNTAILDTCL HGSLVAVTQP VVLDRIEGFK
1210 1220 1230 1240 1250
YYFSNIPSLN ENNNNDDIKE LYVFSDIKPR TNYQTYSISV KIILPNGTLL
1260 1270 1280 1290 1300
VDISNVVCAL VSLGSNPDST IICKPPLNDI YTPYLQSKDS VVNKPEQFKH
1310 1320 1330 1340 1350
LYSVDEFSVN EEDNQFISNE LLLSLFYKHI NNRCPSINLE SLTTLEYNQF
1360 1370 1380 1390 1400
KQLYYNSLVN ENLFKFIFEN LKRYSNILNH DNNQSNIKPK IEKIFIRTTK
1410 1420 1430 1440 1450
IMAKQLFPLK DDDSITDTPQ SLFESGFLDD FYKNSRVVQP LNNLLSEIIV
1460 1470 1480 1490 1500
ETLKPILNEP IVFRILEAGG GTGSLSLLIL EKICKLLNDN STTSIINIEF
1510 1520 1530 1540 1550
TWSDVSASFF AEIKEKFSSF TNHNNLNIIY RVLDLEKPLL DQDLKASYYD
1560 1570 1580 1590 1600
FVVMSNVMHV VKKLKPTLNE IHNILTPNGQ LLYIEPPYKS FYFDSIFGCF
1610 1620 1630 1640 1650
SQWWPSSDGD IELRPDRCCM KQEKWVNLLS QCNYRDTIMS GNDNLLFLIQ
1660 1670 1680 1690 1700
TRKPTINEII SEQSISLDQL NSFNNIILFS NNKNRNSCSS SILDLIRLNQ
1710 1720 1730 1740 1750
ELKHKIININ NYNEFQSWIT NNQNKDNCNK SLIIFLKSIE STMNTSNFKE
1760 1770 1780 1790 1800
ITFEYIQINQ LILKLELSNN FKHLLLSLNS TTDNYLSSSI IGAARYFVEF
1810 1820 1830 1840 1850
PQLDLYILNY DNVSIENNQQ LSLINYLINP NNNIQKEFTI NNNKVYYERY
1860 1870 1880 1890 1900
CRRSNNIKSK FQSESFETNK DNLYIQLNSN IEYQLYSKKD ELNSNEVEIE
1910 1920 1930 1940 1950
VKATGINYKD YLMYIGMIGS DLDIKYGKEI EYGIGIDNPK IGNDFSGIIT
1960 1970 1980 1990 2000
RLGSNVKKFK VGDQVCGFGS KTNSSHVIID FNSIYYKPLN CSHSVSASIP
2010 2020 2030 2040 2050
SIYITTLHSI YSIGNLKSNE SILIHSAAGG IGISSLDLLK SKQHQGYIFL
2060 2070 2080 2090 2100
TVGSKDKEEY LINKYGSLIT AIYSSRNKDY VYEIKNKLIE LGVVEQHQQG
2110 2120 2130 2140 2150
VDLILNTLSS EYMDSNFQCL NLSGRIVDLS ITHLTPNDYM TNNHYKFNMN
2160 2170 2180 2190 2200
YGNVDIEDFP SKLIKRYLKK IIKMINSNKL ELSVPIIEYS NNQFKDAIEY
2210 2220 2230 2240 2250
INQRKHIGKI IVNHNQDEFN RVYNNYQSNN NQIIMKHSYD ISKLNIGKNI
2260 2270 2280 2290 2300
LLTGQTGIVL EILKYLIKYS NHSIENIIIL SKSKLKWELK LLINQSKFKK
2310 2320 2330 2340 2350
DNNIKFHFNQ IDIEDSNKVN QVLNQLELNE NITNIDSIIH FAFMIDIGDV
2360 2370 2380 2390 2400
QQVDMNRLNN AHGAKTIGAI NLHNQSINRS WNIKQFIMAS SVVSIFGSDQ
2410 2420 2430 2440 2450
QCCYVSACSV IDSLSKYRHS IGLPSLAINL GAISSTGFVS RNNAIETMFK
2460 2470 2480 2490 2500
SSIVNLFSPQ LVISSLDLFI QNQHQYPNYC LSDFNFEVLT PTLTNQYHSK
2510 2520 2530 2540 2550
FDYQINIVKK SNRIKSFSSG NSGANNEIIH STILNKISEL LSIDESKINE
2560 2570 2580 2590 2600
DLQLSQYGMD SLVIVQLKNF IDNQLGHNII TIQQLQNNKI NQSIEIIKSA
2610 2620
KNNNKNNNNN NNKNNSNNKN KNN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000167 Genomic DNA Translation: EAL62086.1 |
RefSeqi | XP_635590.1, XM_630498.1 |
Genome annotation databases
EnsemblProtistsi | EAL62086; EAL62086; DDB_G0290703 |
GeneIDi | 8627787 |
KEGGi | ddi:DDB_G0290703 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000167 Genomic DNA Translation: EAL62086.1 |
RefSeqi | XP_635590.1, XM_630498.1 |
3D structure databases
SMRi | Q54FQ1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0235264 |
Proteomic databases
PaxDbi | Q54FQ1 |
PRIDEi | Q54FQ1 |
Genome annotation databases
EnsemblProtistsi | EAL62086; EAL62086; DDB_G0290703 |
GeneIDi | 8627787 |
KEGGi | ddi:DDB_G0290703 |
Organism-specific databases
dictyBasei | DDB_G0290703, pks31 |
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_5_1 |
InParanoidi | Q54FQ1 |
OMAi | AFYHPDH |
PhylomeDBi | Q54FQ1 |
Miscellaneous databases
PROi | PR:Q54FQ1 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS31_DICDI | |
Accessioni | Q54FQ1Primary (citable) accession number: Q54FQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase