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UniProtKB - Q54FN7 (PKS33_DICDI)
Protein
Probable polyketide synthase 33
Gene
pks33
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes and clustered as a pair pks33/pks34 in chromosome 5.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 196 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 670 | For acyl/malonyl transferase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- oxidoreductase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pks33 ORF Names:DDB_G0290729 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0290729, pks33 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2937 – 2957 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000371393 | 1 – 3127 | Probable polyketide synthase 33Add BLAST | 3127 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2576 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | Q54FN7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2539 – 2616 | CarrierPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 177 – 230 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 660 – 693 | Acyl/malonyl transferaseAdd BLAST | 34 | |
Regioni | 1369 – 1394 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 2617 – 2659 | DisorderedSequence analysisAdd BLAST | 43 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 2617 – 2671 | Sequence analysisAdd BLAST | 55 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1178, Eukaryota KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_5_1 |
InParanoidi | Q54FN7 |
OMAi | LRPQWRN |
PhylomeDBi | Q54FN7 |
Family and domain databases
CDDi | cd05235, SDR_e1, 1 hit |
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR013120, Far_NAD-bd IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR010080, Thioester_reductase-like_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF07993, NAD_binding_4, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 3 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54FN7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKENSYNTSI HSNKVKNYDD ADSSGDVAVV GIGLRFPSGN LKESISKPNQ
60 70 80 90 100
LFNELLNGLD GIVSTSERWS DNYCLNGEIV SKFAGLLPLD EWKQFDPIFF
110 120 130 140 150
AINPSNDNVG SIDPQQRLLL KCVWEALEDS GIDPISLRGT NTSTFIGSST
160 170 180 190 200
IDYNNLQKSP FETQNNIFGS TTNSVANRIG YCFDFRGENL TIDTACSSSS
210 220 230 240 250
NAINCGYNSI KSNKSNVSIV GGVNFILDPH ISKSFTQLDM LSPTGKCHTF
260 270 280 290 300
SSDADGYVRS EGVGIVVLKR LKDAIKDSNN IYCVIKGSSS NIDGNFDKLN
310 320 330 340 350
FYSPSKSSQC ENIKLAIKST NGQINESDID YCETHGTGTP TGDPIELEGI
360 370 380 390 400
SRVFNNKAST TKTNNNKQVL VGSVKSNIGH TEACSGVASL IKCCIMFKNK
410 420 430 440 450
LFLQNINFKE PNPLINFKEW GLKVVTEPIK FNENKSTVML INNFGITGSN
460 470 480 490 500
VCLILSEFCS DQFRKSNDYH KMEIDNKFNE KKKYLIPLSS NSSTSLNNYK
510 520 530 540 550
SSIIKHSNLT PFSSPTSFEG FICNQIKFKS TSLIQKSVII ASDWNEFQDE
560 570 580 590 600
SNHIKLENSD NLISNITVEK KKSPLTVMVL CGQGSQYNKM ALSLYDNVPI
610 620 630 640 650
FRESVNRFDK ELFKYYGYSV LDKLRSIDDK DLISIHQPIL AQPANVIIQV
660 670 680 690 700
SLYELYKHWG VSADIIIGHS LGEISSAYCS GMIDFQTLCY LTYHRSVAQN
710 720 730 740 750
RTIGTGRMLS VNISSDEFIN KYQSTTKYKS LEIACYNSPT SIVIAGKEDL
760 770 780 790 800
LNEITNEFKS NDIFCSMLGL LSSFHTSSQQ MIKDEVCSLN ISSKQPSIAV
810 820 830 840 850
FSTVTTNLFN HQTSPFNADY AFNNIRQPVR FTQTITNLYK HIESNDMGNE
860 870 880 890 900
ITFIEVSPHP TLQYYLNQMK STQSSYFNNG KNITIYSPLN KKKNDYNEFL
910 920 930 940 950
KTISLLYVNN NFDINFKSQL INNSNNHTNQ SNNLPLYQWD DKEYFKLNPS
960 970 980 990 1000
LEKIKNEGPS IHSLGNNTDS PYPSYQTFID IKKSPFQWLK GHQVSDKFYY
1010 1020 1030 1040 1050
PGMGYVHNLL SIYPNQDITI SSLEFKSPLV LTEGNRQCLQ TTIAPLSKNE
1060 1070 1080 1090 1100
FNIKSHYKDQ KTNQWILSSL GNFSLFKHNI ENNESINIQS LKDKCNFTTI
1110 1120 1130 1140 1150
SKQDFYETIR IKTNLTYKGL FQGVKECYIG NNCSLVKVSL NEIYNQKEYN
1160 1170 1180 1190 1200
HLINNSNMNT FFNTAILDTC LHGVLVAVTQ PIVLDRIEAF KFYSSNITSS
1210 1220 1230 1240 1250
NISNNDTIKE LYVYSETRAR TNSQTYSGSI KIILPNGTLL VDIGNVVCTI
1260 1270 1280 1290 1300
VGSNPDSTII CKPPSNEIYT PYLQSKDSII NKPEQFKHLY RVDEFSVKEE
1310 1320 1330 1340 1350
DNQLLSIELL LSLFYKHINN RCPSINLESL ATLEYDQFKQ LYYNSLVNEN
1360 1370 1380 1390 1400
LFKFIFEILK KYQNLPKISN NNNNNNNNNN NNNNNNNNNK NNGYNNYENL
1410 1420 1430 1440 1450
YIRTTKVMAK QLFPLKDDDS ITDTPQSLFE IGYLNEFYKN SNVIQPSNNL
1460 1470 1480 1490 1500
LSEIIVETLK PILNEPIVFR ILEAGGGTGS LSLLILEKIC KLLNDNSTTS
1510 1520 1530 1540 1550
IINIEFTWSD ISASFFAEIK EKFSSFTNHN NLNIIYRVLD LEKPLLDQDL
1560 1570 1580 1590 1600
KASYYDFVVM SNVMHVVKKL KPTLNEIHNI LTPNGQLLYI EPPYKSFYYD
1610 1620 1630 1640 1650
SIFGCFSQWW PSSDSDIELR PDRCCMKQEK WINLLNQCNY KDTIMSGNDN
1660 1670 1680 1690 1700
LAFLIQTRKP TINEIISEES KSLDQLNSFS NIILFSNNNN IRNNNNRNKN
1710 1720 1730 1740 1750
DSRSSIQNLI SLNQELRHKI VNINNYNEFQ SWITNNQNKD DCNKTLIIFL
1760 1770 1780 1790 1800
KSIESTMNTF NFKEITFEYI QINQLILKLE LSNNFKHLLL SLNSSTDNYL
1810 1820 1830 1840 1850
SSSIIGSARY FHVEFPQLDL LTLNYDNVSI ENNQQLSLIN YLINSDNNIQ
1860 1870 1880 1890 1900
IEFTINNNKV YYERYFKRSN NIKSKLQSES FETNKDNLYI QLNSNLEYQL
1910 1920 1930 1940 1950
YSKKDELNSN EVEIEIKATG INYKDYLMYI GMIGSDLDIK YGKEYEIENG
1960 1970 1980 1990 2000
IGIDNPNIGN DFSGIITRLG NNVKKFKVGD QVCGIGPKAS SSHVIVDFNF
2010 2020 2030 2040 2050
IYYKPFNCNH SVSASIPSIY ITSLHSIYSI GNLKSNESIL IHSAAGGIGI
2060 2070 2080 2090 2100
SSLDLLKSKQ HQGYIFLTVG SKDKEEYLTK KYGSLITAIY SSRNKNYVKD
2110 2120 2130 2140 2150
IKNKLIELGE VEQQGVDLIL NTLSSEYMDS NFQCLNLSGR IIDLSITHLT
2160 2170 2180 2190 2200
PNDYMTNNHF KFNMTYSNVE VVDFTSKLIK SYLKKIIKMI NSNKLELSVP
2210 2220 2230 2240 2250
IIEYSNNQFK DAIEYINQRK HIGKIIVNHN QDEFNRVYNN YQSNNNHIIM
2260 2270 2280 2290 2300
KHSYDISKLN IGKNILLTGQ TGIVLEILKY LIKYSNHSIE NIIILSKSKL
2310 2320 2330 2340 2350
KWELELLINQ SKFKKDNIIK FHFNQIDIED SNKVNQVLNQ LELNENITNI
2360 2370 2380 2390 2400
DSIIHFAFMN DISDIQQVDM NRLNNTHGAK TIGAINLHNQ SINRSWNIKQ
2410 2420 2430 2440 2450
FIMASSVVSI VGSDRQCCYV SACNVIDSLS KYRHSIGLPS LAINLGAISS
2460 2470 2480 2490 2500
TGFISRNNAI ETMFKSSILN LFSPQLIISS LDLFIQNQHQ YPNYCISDFN
2510 2520 2530 2540 2550
FEILPSTLTN QYLSKFDFEI NIVKKSNQMK SFTGGNGDSN NEIIRSTILN
2560 2570 2580 2590 2600
KISELLSIDE SKINEDLQLT QYGMDSLVIV QLKNFIDNQI GHNIITIQQL
2610 2620 2630 2640 2650
QNNKINQSIE IIKSAHNKNN NNNNINNNNN NNNNNNNNNN NNNNNNNNNN
2660 2670 2680 2690 2700
NNNNNNNNNL VKKEQQSLDE FIKNETKLNE SIISRPYSIK NILNNNNNSK
2710 2720 2730 2740 2750
SIFLTGSTGF LGAYLLTELI KMNNVSKIYC LIRNNSKLTN PIDVIINNLK
2760 2770 2780 2790 2800
KHQLIDMNEE SPKRKTKIND HTGNISNDKL YGNLNSDNSS NNQIKEDQLI
2810 2820 2830 2840 2850
KIIPMIGDIS KDKFGLTEQD YLKLSNECDI IINSAADLNL KSSYEESKIV
2860 2870 2880 2890 2900
NINNVNQIIK LSISNNSSQK LIVHFSSLAV FINHPFEDGE DFEETNIVPS
2910 2920 2930 2940 2950
FNSTPVGYIQ CKVISERLLT NAAESRGIPS IIIRPPVLTL YNIPITIFIA
2960 2970 2980 2990 3000
ILIIDIFSNP ITGIGHSNDF ISLLIKSSKE IGYYPNIHKS VFTTPVTTIA
3010 3020 3030 3040 3050
KTTIDLIFNE NSWNQNKSKP ISIYNFNGDS IEMKSFYRVL ENSFKCKEID
3060 3070 3080 3090 3100
FYEWIELVSK SNGKSSKRYS TFHIHKNQNL LITSSKINSL FKMSNSTKEL
3110 3120
LISIGSYNHQ DWEINESIIL NDIINNH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000169 Genomic DNA Translation: EAL62070.2 |
RefSeqi | XP_635575.2, XM_630483.2 |
Genome annotation databases
EnsemblProtistsi | EAL62070; EAL62070; DDB_G0290729 |
GeneIDi | 8627799 |
KEGGi | ddi:DDB_G0290729 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000169 Genomic DNA Translation: EAL62070.2 |
RefSeqi | XP_635575.2, XM_630483.2 |
3D structure databases
SMRi | Q54FN7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0235230 |
Proteomic databases
PaxDbi | Q54FN7 |
Genome annotation databases
EnsemblProtistsi | EAL62070; EAL62070; DDB_G0290729 |
GeneIDi | 8627799 |
KEGGi | ddi:DDB_G0290729 |
Organism-specific databases
dictyBasei | DDB_G0290729, pks33 |
Phylogenomic databases
eggNOGi | KOG1178, Eukaryota KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_5_1 |
InParanoidi | Q54FN7 |
OMAi | LRPQWRN |
PhylomeDBi | Q54FN7 |
Miscellaneous databases
PROi | PR:Q54FN7 |
Family and domain databases
CDDi | cd05235, SDR_e1, 1 hit |
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR013120, Far_NAD-bd IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR010080, Thioester_reductase-like_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF07993, NAD_binding_4, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 3 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS33_DICDI | |
Accessioni | Q54FN7Primary (citable) accession number: Q54FN7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | March 18, 2008 | |
Last modified: | February 23, 2022 | |
This is version 111 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase