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Entry version 119 (23 Feb 2022)
Sequence version 1 (24 May 2005)
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Protein

Polyketide synthase 37

Gene

StlB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyketide synthase; part of the gene cluster that mediates the biosynthesis of DIF-1 (Differentiation Inducing Factor-1), a signal molecule involved in the differentiation of pstO (prestalk-O) cells (PubMed:16906151).

The three-step process begins with the formation of (2,4,6-trihydroxyphenyl)-1-hexan-1-one (THPH) by the polyketide synthase StlB (PubMed:16906151).

THPH is then dichlorinated by the flavin-dependent halogenase ChlA (PubMed:20231486).

The last step of DIF-1 biosynthesis is the O-methylation of dichloro-THPH (or des-methyl-DIF-1) by the methyltransferase DmtA to yield DIF-1 (PubMed:9446571).

3 Publications

Miscellaneous

Encoded by one of the numerous copies of polyketide synthase genes localized in chromosome 5.
In reference to their hybrid nature and to their discovery in D.discoideum, authors term these type I FAS-type III PKS fusion enzymes 'steely'.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei198For beta-ketoacyl synthase activityPROSITE-ProRule annotation1
Active sitei718For malonyltransferase activityPROSITE-ProRule annotation1
Active sitei2747PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Multifunctional enzyme, Transferase

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00154

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyketide synthase 371 Publication
Short name:
dipks371 Publication
Including the following 2 domains:
Highly reducing polyketide synthase StlB1 Publication (EC:2.3.1.-1 Publication)
Chalcone synthase1 Publication (EC:2.3.1.741 Publication)
Alternative name(s):
Steely21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:StlB
Synonyms:pks37
ORF Names:DDB_G0290853
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0290853, stlB

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Developed to the slug stage, in which dif-1 accumulation is maximal, though the Steely2- mutant slugs were thin and tended to break up. However, two independent Steely2 mutant strains both failed to accumulate any detectable dif-1 at this or any other stage of development.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003779021 – 2968Polyketide synthase 37Add BLAST2968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2458O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54FI3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during development. Coordinately expressed with dmtA.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0234163

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54FI3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2421 – 2498CarrierPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 406Ketosynthase (KS) domainSequence analysis1 PublicationAdd BLAST374
Regioni624 – 950Malonyl-CoA:ACP transacylase (MAT) domainSequence analysis1 PublicationAdd BLAST327
Regioni1031 – 1345Dehydrogenase (DH) domainSequence analysis1 PublicationAdd BLAST315
Regioni1522 – 1547DisorderedSequence analysisAdd BLAST26
Regioni1718 – 2053Enoyl reductase (ER) domainSequence analysis1 PublicationAdd BLAST336
Regioni2083 – 2277Ketoreductase (KR) domainSequence analysis1 PublicationAdd BLAST195
Regioni2379 – 2400DisorderedSequence analysisAdd BLAST22
Regioni2568 – 2589DisorderedSequence analysisAdd BLAST22
Regioni2707 – 2968Chalcone synthaseSequence analysis1 PublicationAdd BLAST262

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2568 – 2585Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Modular protein possessing six classical catalytic domains and a type III polyketide synthase domain. May facilitate covalent transfer of steely N-terminal acyl products directly to the C-terminal type III PKS active sites, which catalyze both iterative polyketide extension and cyclization.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1202, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_31_5_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q54FI3

Identification of Orthologs from Complete Genome Data

More...
OMAi
KMRGGEF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54FI3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR013149, ADH_C
IPR013154, ADH_N
IPR012328, Chalcone/stilbene_synt_C
IPR001099, Chalcone/stilbene_synt_N
IPR011032, GroES-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR020843, PKS_ER
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR016039, Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF08240, ADH_N, 1 hit
PF00107, ADH_zinc_N, 1 hit
PF02797, Chal_sti_synt_C, 1 hit
PF00195, Chal_sti_synt_N, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827, PKS_AT, 1 hit
SM00829, PKS_ER, 1 hit
SM00825, PKS_KS, 1 hit
SM00823, PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 1 hit
SSF50129, SSF50129, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53901, SSF53901, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54FI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNNKSINDL SGNSNNNIAN SNINNYNNLI KKEPIAIIGI GCRFPGNVSN
60 70 80 90 100
YSDFVNIIKN GSDCLTKIPD DRWNADIISR KQWKLNNRIG GYLKNIDQFD
110 120 130 140 150
NQFFGISPKE AQHIDPQQRL LLHLAIETLE DGKISLDEIK GKKVGVFIGS
160 170 180 190 200
SSGDYLRGFD SSEINQFTTP GTNSSFLSNR LSYFLDVNGP SMTVNTACSA
210 220 230 240 250
SMVAIHLGLQ SLWNGESELS MVGGVNIISS PLQSLDFGKA GLLNQETDGR
260 270 280 290 300
CYSFDPRASG YVRSEGGGIL LLKPLSAALR DNDEIYSLLL NSANNSNGKT
310 320 330 340 350
PTGITSPRSL CQEKLIQQLL RESSDQFSID DIGYFECHGT GTQMGDLNEI
360 370 380 390 400
TAIGKSIGML KSHDDPLIIG SVKASIGHLE GASGICGVIK SIICLKEKIL
410 420 430 440 450
PQQCKFSSYN PKIPFETLNL KVLTKTQPWN NSKRICGVNS FGVGGSNSSL
460 470 480 490 500
FLSSFDKSTT ITEPTTTTTI ESLPSSSSSF DNLSVSSSIS TNNDNDKVSN
510 520 530 540 550
IVNNRYGSSI DVITLSVTSP DKEDLKIRAN DVLESIKTLD DNFKIRDISN
560 570 580 590 600
LTNIRTSHFS NRVAIIGDSI DSIKLNLQSF IKGENNNNKS IILPLINNGN
610 620 630 640 650
NNNNNNNNSS GSSSSSSNNN NICFIFSGQG QQWNKMIFDL YENNKTFKNE
660 670 680 690 700
MNNFSKQFEM ISGWSIIDKL YNSGGGGNEE LINETWLAQP SIVAVQYSLI
710 720 730 740 750
KLFSKDIGIE GSIVLGHSLG ELMAAYYCGI INDFNDLLKL LYIRSTLQNK
760 770 780 790 800
TNGSGRMHVC LSSKAEIEQL ISQLGFNGRI VICGNNTMKS CTISGDNESM
810 820 830 840 850
NQFTKLISSQ QYGSVVHKEV RTNSAFHSHQ MDIIKDEFFK LFNQYFPTNQ
860 870 880 890 900
ISTNQIYDGK SFYSTCYGKY LTPIECKQLL SSPNYWWKNI RESVLFKESI
910 920 930 940 950
EQILQNHQQS LTFIEITCHP ILNYFLSQLL KSSSKSNTLL LSTLSKNSNS
960 970 980 990 1000
IDQLLILCSK LYVNNLSSIK WNWFYDKQQQ QQSESLVSSN FKLPGRRWKL
1010 1020 1030 1040 1050
EKYWIENCQR QMDRIKPPMF ISLDRKLFSV TPSFEVRLNQ DRFQYLNDHQ
1060 1070 1080 1090 1100
IQDIPLVPFS FYIELVYASI FNSISTTTTN TTASTMFEIE NFTIDSSIII
1110 1120 1130 1140 1150
DQKKSTLIGI NFNSDLTKFE IGSINSIGSG SSSNNNFIEN KWKIHSNGII
1160 1170 1180 1190 1200
KYGTNYLKSN SKSNSFNEST TTTTTTTTTT KCFKSFNSNE FYNEIIKYNY
1210 1220 1230 1240 1250
NYKSTFQCVK EFKQFDKQGT FYYSEIQFKK NDKQVIDQLL SKQLPSDFRC
1260 1270 1280 1290 1300
IHPCLLDAVL QSAIIPATNK TNCSWIPIKI GKLSVNIPSN SYFNFKDQLL
1310 1320 1330 1340 1350
YCLIKPSTST STSPSTYFSS DIQVFDKKNN NLICELTNLE FKGINSSSSS
1360 1370 1380 1390 1400
SSSSSTINSN VEANYESKIE ETNHDEDEDE ELPLVSEYVW CKEELINQSI
1410 1420 1430 1440 1450
KFTDNYQTVI FCSTNLNGND LLDSIITSAL ENGHDENKIF IVSPPPVESD
1460 1470 1480 1490 1500
QYNNRIIINY TNNESDFDAL FAIINSTTSI SGKSGLFSTR FIILPNFNSI
1510 1520 1530 1540 1550
TFSSGNSTPL ITNVNGNGNG KSCGGGGGST NNTISNSSSS ISSIDNGNNE
1560 1570 1580 1590 1600
DEEMVLKSFN DSNLSLFHLQ KSIIKNNIKG RLFLITNGGQ SISSSTPTST
1610 1620 1630 1640 1650
YNDQSYVNLS QYQLIGQIRV FSNEYPIMEC SMIDIQDSTR IDLITDQLNS
1660 1670 1680 1690 1700
TKLSKLEIAF RDNIGYSYKL LKPSIFDNSS LPSSSSEIET TATTKDEEKN
1710 1720 1730 1740 1750
NSINYNNNYY RVELSDNGII SDLKIKQFRQ MKCGVGQVLV RVEMCTLNFR
1760 1770 1780 1790 1800
DILKSLGRDY DPIHLNSMGD EFSGKVIEIG EGVNNLSVGQ YVFGINMSKS
1810 1820 1830 1840 1850
MGSFVCCNSD LVFPIPIPTP SSSSSSNENI DDQEIISKLL NQYCTIPIVF
1860 1870 1880 1890 1900
LTSWYSIVIQ GRLKKGEKIL IHSGCGGVGL ATIQISMMIG AEIHVTVGSN
1910 1920 1930 1940 1950
EKKQYLIKEF GIDEKRIYSS RSLQFYNDLM VNTDGQGVDM VLNSLSGEYL
1960 1970 1980 1990 2000
EKSIQCLSQY GRFIEIGKKD IYSNSSIHLE PFKNNLSFFA VDIAQMTENR
2010 2020 2030 2040 2050
RDYLREIMID QLLPCFKNGS LKPLNQHCFN SPCDLVKAIR FMSSGNHIGK
2060 2070 2080 2090 2100
ILINWSNLNN DKQFINHHSV VHLPIQSFSN RSTYIFTGFG GLTQTLLKYF
2110 2120 2130 2140 2150
STESDLTNVI IVSKNGLDDN SGSGSGNNEK LKLINQLKES GLNVLVEKCD
2160 2170 2180 2190 2200
LSSIKQVYKL FNKIFDNDAS GSDSGDFSDI KGIFHFASLI NDKRILKHNL
2210 2220 2230 2240 2250
ESFNYVYNSK ATSAWNLHQV SLKYNLNLDH FQTIGSVITI LGNIGQSNYT
2260 2270 2280 2290 2300
CANRFVEGLT HLRIGMGLKS SCIHLASIPD VGMASNDNVL NDLNSMGFVP
2310 2320 2330 2340 2350
FQSLNEMNLG FKKLLSSPNP IVVLGEINVD RFIEATPNFR AKDNFIITSL
2360 2370 2380 2390 2400
FNRIDPLLLV NESQDFIINN NINNNGGGGD GSFDDLNQLE DEGQQGFGNG
2410 2420 2430 2440 2450
DGYVDDNIDS VSMLSGTSSI FDNDFYTKSI RGMLCDILEL KDKDLNNTVS
2460 2470 2480 2490 2500
FSDYGLDSLL SSELSNTIQK NFSILIPSLT LVDNSTINST VELIKNKLKN
2510 2520 2530 2540 2550
STTSSISSSV SKKVSFKKNT QPLIIPTTAP ISIIKTQSYI KSEIIESLPI
2560 2570 2580 2590 2600
SSSTTIKPLV FDNLVYSSSS SNNSNSKNEL TSPPPSAKRE SVLPIISEDN
2610 2620 2630 2640 2650
NSDNDSSMAT VIYEISPIAA PYHRYQTDVL KEITQLTPHK EFIDNIYKKS
2660 2670 2680 2690 2700
KIRSRYCFND FSEKSMADIN KLDAGERVAL FREQTYQTVI NAGKTVIERA
2710 2720 2730 2740 2750
GIDPMLISHV VGVTSTGIMA PSFDVVLIDK LGLSINTSRT MINFMGCGAA
2760 2770 2780 2790 2800
VNSMRAATAY AKLKPGTFVL VVAVEASATC MKFNFDSRSD LLSQAIFTDG
2810 2820 2830 2840 2850
CVATLVTCQP KSSLVGKLEI IDDLSYLMPD SRDALNLFIG PTGIDLDLRP
2860 2870 2880 2890 2900
ELPIAINRHI NSAITSWLKK NSLQKSDIEF FATHPGGAKI ISAVHEGLGL
2910 2920 2930 2940 2950
SPEDLSDSYE VMKRYGNMIG VSTYYVLRRI LDKNQTLLQE GSLGYNYGMA
2960
MAFSPGASIE AILFKLIK
Length:2,968
Mass (Da):329,909
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98AA21F6256A8A57
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AAFI02000171 Genomic DNA Translation: EAL62021.1

NCBI Reference Sequences

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RefSeqi
XP_635518.1, XM_630426.1

Genome annotation databases

Ensembl protists genome annotation project

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EnsemblProtistsi
EAL62021; EAL62021; DDB_G0290853

Database of genes from NCBI RefSeq genomes

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GeneIDi
8627855

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ddi:DDB_G0290853

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000171 Genomic DNA Translation: EAL62021.1
RefSeqiXP_635518.1, XM_630426.1

3D structure databases

SMRiQ54FI3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0234163

Proteomic databases

PaxDbiQ54FI3

Genome annotation databases

EnsemblProtistsiEAL62021; EAL62021; DDB_G0290853
GeneIDi8627855
KEGGiddi:DDB_G0290853

Organism-specific databases

dictyBaseiDDB_G0290853, stlB

Phylogenomic databases

eggNOGiKOG1202, Eukaryota
HOGENOMiCLU_000022_31_5_1
InParanoidiQ54FI3
OMAiKMRGGEF
PhylomeDBiQ54FI3

Enzyme and pathway databases

UniPathwayiUPA00154

Miscellaneous databases

Protein Ontology

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PROi
PR:Q54FI3

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 3 hits
InterProiView protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR013149, ADH_C
IPR013154, ADH_N
IPR012328, Chalcone/stilbene_synt_C
IPR001099, Chalcone/stilbene_synt_N
IPR011032, GroES-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR020843, PKS_ER
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR016039, Thiolase-like
PfamiView protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF08240, ADH_N, 1 hit
PF00107, ADH_zinc_N, 1 hit
PF02797, Chal_sti_synt_C, 1 hit
PF00195, Chal_sti_synt_N, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit
SMARTiView protein in SMART
SM00827, PKS_AT, 1 hit
SM00829, PKS_ER, 1 hit
SM00825, PKS_KS, 1 hit
SM00823, PKS_PP, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
SSF50129, SSF50129, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53901, SSF53901, 3 hits
PROSITEiView protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTLB_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54FI3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 24, 2005
Last modified: February 23, 2022
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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