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UniProtKB - Q54FF4 (GACL_DICDI)
Protein
Rho GTPase-activating protein gacL
Gene
gacL
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Rho GTPase-activating protein involved in the signal transduction pathway.
By similarityGO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
GO - Biological processi
- signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
Reactomei | R-DDI-9013148, CDC42 GTPase cycle R-DDI-9013149, RAC1 GTPase cycle R-DDI-9013404, RAC2 GTPase cycle R-DDI-9013406, RHOQ GTPase cycle R-DDI-9013409, RHOJ GTPase cycle R-DDI-9013423, RAC3 GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein gacLAlternative name(s): GTPase activating factor for raC protein L |
Gene namesi | Name:gacL ORF Names:DDB_G0290891 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0290891, gacL |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000380210 | 1 – 734 | Rho GTPase-activating protein gacLAdd BLAST | 734 |
Proteomic databases
PaxDbi | Q54FF4 |
PRIDEi | Q54FF4 |
Expressioni
Inductioni
Down-regulated by phagocytic stimuli.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 141 – 339 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 199 | |
Repeati | 381 – 430 | WD 1Add BLAST | 50 | |
Repeati | 539 – 579 | WD 2Add BLAST | 41 | |
Repeati | 585 – 623 | WD 3Add BLAST | 39 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG4270, Eukaryota |
HOGENOMi | CLU_377876_0_0_1 |
InParanoidi | Q54FF4 |
OMAi | WIGGDEG |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR011047, Quinoprotein_ADH-like_supfam IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF50998, SSF50998, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54FF4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDIELFLSNY NIANGTSSTT ANNSKFQPKI KVKLVVESGS STYEKSLEST
60 70 80 90 100
NDQLKPLIIK LNNKIKKYEE SLNKKNFVTP NKQSSSSMNL LQKSSTVNLS
110 120 130 140 150
SPSLSQIGLT HHASLKNLQI TTSPDIQQPP SVPSNPIVFG ISLDTLIAKE
160 170 180 190 200
KSMELRIPTF VSNILNTLFL HSLGVEGLFR ISGSQMEIQN RRGIVNLGDY
210 220 230 240 250
STSRDDNPHV LTVLLKQFLR DLPEPICTNA LYDLFLAASD QINFQQCKEN
260 270 280 290 300
GFEVLKKLIN SNLPVNNRNL LQHLIHFLRF VAMNQTVNLM GPSNLSRVFG
310 320 330 340 350
PNLFWKKETG PLDIQILQST SEKVNFITEQ MILHYDTLFE EPLQTTSPAV
360 370 380 390 400
LSNTPINSNP ASIPTFNFGG KKLVIHSKLL GHNKSIQWMT LCGSSNSNGN
410 420 430 440 450
SELSGSRVWS LDSHGMARIW DSQNQQFIKE VEVVDQSKGG GGAVYQMIST
460 470 480 490 500
TVNNTVWTAT SQKLAIWDID GGLIGEIPGE SYSLCESQNK EIWVGGPQVL
510 520 530 540 550
NIYSLDGIPS IAPSNCTSDD NNSNGAGGGE LLKPIGTNLF MKGIIILAMC
560 570 580 590 600
KVGQNRIWGC SSEKTLYVWD TKTKETIHQC EIQEKRPKRM ACIEIDDTEY
610 620 630 640 650
IWIGGDEGSI QIFNSKTFKL EHKILNQGWD KIFHIASINR EIWIGFWDTT
660 670 680 690 700
VRVFPGDPKN KEILIDYKGY HSDVVSSIIE VPNLKGGDPF VWFGSYDKSI
710 720 730
SIVSIKEDTA KSWNFTNIKK NFTRPIRQGF SSRG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000171 Genomic DNA Translation: EAL62010.1 |
RefSeqi | XP_635517.1, XM_630425.1 |
Genome annotation databases
EnsemblProtistsi | EAL62010; EAL62010; DDB_G0290891 |
GeneIDi | 8627884 |
KEGGi | ddi:DDB_G0290891 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000171 Genomic DNA Translation: EAL62010.1 |
RefSeqi | XP_635517.1, XM_630425.1 |
3D structure databases
AlphaFoldDBi | Q54FF4 |
SMRi | Q54FF4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0233793 |
Proteomic databases
PaxDbi | Q54FF4 |
PRIDEi | Q54FF4 |
Genome annotation databases
EnsemblProtistsi | EAL62010; EAL62010; DDB_G0290891 |
GeneIDi | 8627884 |
KEGGi | ddi:DDB_G0290891 |
Organism-specific databases
dictyBasei | DDB_G0290891, gacL |
Phylogenomic databases
eggNOGi | KOG4270, Eukaryota |
HOGENOMi | CLU_377876_0_0_1 |
InParanoidi | Q54FF4 |
OMAi | WIGGDEG |
Enzyme and pathway databases
Reactomei | R-DDI-9013148, CDC42 GTPase cycle R-DDI-9013149, RAC1 GTPase cycle R-DDI-9013404, RAC2 GTPase cycle R-DDI-9013406, RHOQ GTPase cycle R-DDI-9013409, RHOJ GTPase cycle R-DDI-9013423, RAC3 GTPase cycle |
Miscellaneous databases
PROi | PR:Q54FF4 |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR011047, Quinoprotein_ADH-like_supfam IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF50998, SSF50998, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GACL_DICDI | |
Accessioni | Q54FF4Primary (citable) accession number: Q54FF4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase