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UniProtKB - Q54FC8 (PKS39_DICDI)
Protein
Probable polyketide synthase 39
Gene
pks39
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes and clustered as a pair pks38/pks39 in chromosome 5.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 181 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 653 | For acyl/malonyl transferase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- oxidoreductase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pks39 ORF Names:DDB_G0290943 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0290943, pks39 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2702 – 2722 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000371396 | 1 – 3108 | Probable polyketide synthase 39Add BLAST | 3108 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2603 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | Q54FC8 |
PRIDEi | Q54FC8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2566 – 2643 | CarrierPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 215 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 643 – 676 | Acyl/malonyl transferaseAdd BLAST | 34 | |
Regioni | 1375 – 1435 | DisorderedSequence analysisAdd BLAST | 61 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1178, Eukaryota KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_5_1 |
InParanoidi | Q54FC8 |
OMAi | WYLHEAT |
PhylomeDBi | Q54FC8 |
Family and domain databases
CDDi | cd05235, SDR_e1, 1 hit |
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013120, Far_NAD-bd IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR010080, Thioester_reductase-like_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF07993, NAD_binding_4, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 3 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54FC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTENIDKNDD DVAVIGIGLR FPSGNLKESI SKPNQLFNEL LNGLDGIVTT
60 70 80 90 100
SERWSDNYYL NGEVVSKFAG LLPLDEWKQF DPIFFAINPS YDNVSSIDPQ
110 120 130 140 150
QRLLLKCVWE ALEDSGIDPI SLRGTNTSTF IGSSTIDYND LQKSPFETQN
160 170 180 190 200
NIFGSTTHSI ANRIGFSFDF RGENLTIDTA CSSSSNAINC GYNSIKSNKS
210 220 230 240 250
NVSIVGGVNF ILNPYISKSF TQLDMLSPTG KCHTFSSDAD GFVRSEGVGI
260 270 280 290 300
VVLKKLKDAI KDSNNIYCVI KGSSSNIDGN FDKLNFYSPS KLSQCENIKL
310 320 330 340 350
AIKSTNGQIN ESDIDYCETH GTGTPTGDPI ELEGISRAFN NKASTTNNNK
360 370 380 390 400
QVLVGSFKSN IGHTEACSGV ASLIKCCLMF KNKLFLQNIN FKEPNPLINF
410 420 430 440 450
KEWGLKVVTE PIKFNENKPT VMLINNFGIT GSNVCLILSE FSGNSKSNDY
460 470 480 490 500
QKMEIDNKFN EKKKYLIPLS SNSSTSLNNY KLSIIKHLNS RSSSSSTTTS
510 520 530 540 550
FEEFVYNQIK FKSTSLIQKS VIIASDWNEF QDENNQIKLE NSDNLISNIT
560 570 580 590 600
VEKKKSPIIV MVLCGQGSQY NKMALSLYDN EPIFREYVNR FDKELFKYYG
610 620 630 640 650
YSVLDKLRSI EDKDLISIHQ PILAQPATVI IQVSLYELYK HWGVSADIII
660 670 680 690 700
GHSLGEISSA YCSGMIDFQT LCYLTYHRSV AQNRTTGTGK MLSVNISSDE
710 720 730 740 750
FINSYQSTTK YESLEIACYN SPTSIVIAGK EDLLNEIIKD FKSNDIFCAM
760 770 780 790 800
LGSLSSFHTS SQQMIKDEVC SLNISSKQPS IAIFSTVTTN LFNHQSSPFD
810 820 830 840 850
ADYVFDNIRQ PVRFTQTITN LYKYAESNDM GNEITFIEVS PHPTLQFYLN
860 870 880 890 900
QMNSTQSSYF NSGKNITIYS PLNKKKNDYN EFLKTISLLY VNNNLNINFK
910 920 930 940 950
SQLINNNNNN NNNNYTNLFN NLPLYQWDDK EYFKITSFHE KIKSEGPSIH
960 970 980 990 1000
SLGNNTDSPY PSYQTFIDIK KSPFQWLKGH QVSDKFYYPG MGHVHNLLSI
1010 1020 1030 1040 1050
YPNQDITISS LEFKSPLVLA EGNRQCLQTS VTPLSKNEFN IKSHYKDQKT
1060 1070 1080 1090 1100
NQWILTSLGN FSLFKHNIIE NNQPINIQTL KDKCNFTSIS KQDLYETIRI
1110 1120 1130 1140 1150
KTNLTYKGLF QGVKQCHIGN NCSLAIVSLN EIYIQKEYNH LINNSNMNTL
1160 1170 1180 1190 1200
FNTAILDTCL HGVLCAVTQP VVLDRIEGFN FYSSNIPSSL NYRNNNNNNN
1210 1220 1230 1240 1250
NINNNNNNNN NSNNTINEFY VYSEIRARTN FQTYSGSIKI ILPNGTLLVD
1260 1270 1280 1290 1300
IGNVVCTIAA SNPDSSLICK PNYIYTPHLQ SKDSIINKPE QFKHLHRVNE
1310 1320 1330 1340 1350
FSFKNEENLF ISNRLLLSLF YKHINNRCPS INLESLETLE YDQFKQLYYN
1360 1370 1380 1390 1400
SLVNENLFKF IFEILKKYQN IPNINNNNNN NNNNNNNNNN NNNNNNNNNN
1410 1420 1430 1440 1450
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNEKLYI KTTKIMAKQL
1460 1470 1480 1490 1500
FPLKDDDSIT DTPQSLFESG YLDVFYKNSI VVQPLNSLLS EIIVETLKPI
1510 1520 1530 1540 1550
LNEPIVFRIL EAGGGTGSLS LLILEKICKL LNENNSTTSI IDIEFTWSDI
1560 1570 1580 1590 1600
SASFFAEIKE KFSSFTNHNS LNIIYRVLDL DKPLLDQDLK ASYYDFVVMS
1610 1620 1630 1640 1650
NVMHVVKKLK PTLNEIHNIL APNGQLLFVE PPYKSFFIDS IFGCFSQWWP
1660 1670 1680 1690 1700
SSDSDIELRP DRCCMKQEKW INLLNQCNYR DTIMSGNDNL LFLVQTRKPT
1710 1720 1730 1740 1750
INEIISEQSI SLDQLKSFNN IILFSSNNKN NKNDSFSIIQ NLITLNQELK
1760 1770 1780 1790 1800
HKIININNYN EFQSWITNNQ NIDNKTLIIF LKSIDSTVNT SNFKETTFEY
1810 1820 1830 1840 1850
IQINQLILKL ELSNNFKHLL LSLNSTTDNY LTSSIVGAAR YFIEFPQLDL
1860 1870 1880 1890 1900
LTLNYDNVSI ENNQQLLSLI NYLINSNNNI QKEFTINNNI VYYERFCKRL
1910 1920 1930 1940 1950
NNIKSKFQSK SFETNKDNLY IQLNSNLEYQ LYSKKDELNS NEVEIEIKAT
1960 1970 1980 1990 2000
GINYKDYLLH IGMIGTNLEI KYGKEIENGI GFDNPKIGND FSGIITRLGC
2010 2020 2030 2040 2050
NVKEFKVGDQ VCGFGSKTNS SHIIVDSDSI YYKPLYYSHS VSASIPSIYI
2060 2070 2080 2090 2100
TSLHSIYGIG NLKSNESILI HSAAGGVGLS SLDLLKSKQH QGYIFLTVGS
2110 2120 2130 2140 2150
KDKEEYLINK YGSLITAIYS SRNKNYVYEI KNKLIELGEV EQHQQGVDLI
2160 2170 2180 2190 2200
LNTLSSEFMS PNFQCLNLSG RIVDLSITHL TPNDYMTNSH YKFNMGYNNV
2210 2220 2230 2240 2250
NVEDFPGKLI KSYLKKIIEM INSNELELSV PIIEYSNNQF KDAIEYINQR
2260 2270 2280 2290 2300
KHIGKIIVNH SQDEFNRVYN NYQNNNNQII MKHSYDISKL NIGKNIILTG
2310 2320 2330 2340 2350
QTGIVLEILK YLVKYSNHSI ENIIILSKSK LKWELELLIN QTKFKKDNII
2360 2370 2380 2390 2400
KFHFNQIDIE DSNKVNQALN QLELNENITN IDSIIHFAFM NDIGDVQQVD
2410 2420 2430 2440 2450
MNRLNNAHGA KTIGAINLHN QSINRSWNIK QFIMASSVAS IVGSEQQCCY
2460 2470 2480 2490 2500
VSACNVIDSL SKYRHSIGLP SLAINLGTIS STGFITRNNT IETMLKSSIL
2510 2520 2530 2540 2550
NFLSPQLVIS SLDLFIQNQH QYPNYCMSDF KFKIIPSTNQ YFSKFDFEIN
2560 2570 2580 2590 2600
IVKKSNQIKS FFGGDGNNEI IHSTILNKIS ELLSIDKSKI NEDLQLTQYG
2610 2620 2630 2640 2650
TDSLVIVQLK NFIDNQLGHN IITIQQLQNN KINQSIEIIK SALNKNNNIY
2660 2670 2680 2690 2700
NNKKNNNNNL VKKEQQSLDE FIKNETKLNE SIISRPYSIK KILNNNNNSK
2710 2720 2730 2740 2750
SIFLTGSTGF LGAYLLMELI KMNNISKIYC LIRNNSKLTN PIDVIINNLK
2760 2770 2780 2790 2800
KHQLIDMNKE SPKRKTKIIN HTGNISNDKL NSSDNSNNNN NQINEDQLIK
2810 2820 2830 2840 2850
IIPMIGDISK DKFGLTEQDY LKLSNECDII INSAADLNLK SNYEESKTIN
2860 2870 2880 2890 2900
VNNVNQVIKL SVSNNSSQKL IVHFSSLAVF INHPFKDEED FEETNIVPNF
2910 2920 2930 2940 2950
NSTPIGYIQS KVISEKLLTN AAESRGIPSI IIRPPDIFSN PITGIGHSND
2960 2970 2980 2990 3000
FLSLLIKASK DIGYYPNIHK SIFSTPVTTI AKTTIDLIFN ENSWNQNKSK
3010 3020 3030 3040 3050
PISIYNFNGN SMEFKSFYRV LENNFKCKEI DFDEWIELVS KSNGKSSKRY
3060 3070 3080 3090 3100
STFHIHKNQN LLLTTFTINS LFKMSNSTKE LLISIGSYNH QDWEINESMI
LNDIINNH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000172 Genomic DNA Translation: EAL61987.1 |
RefSeqi | XP_635494.1, XM_630402.1 |
Genome annotation databases
EnsemblProtistsi | EAL61987; EAL61987; DDB_G0290943 |
GeneIDi | 8627910 |
KEGGi | ddi:DDB_G0290943 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000172 Genomic DNA Translation: EAL61987.1 |
RefSeqi | XP_635494.1, XM_630402.1 |
3D structure databases
SMRi | Q54FC8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0237714 |
Proteomic databases
PaxDbi | Q54FC8 |
PRIDEi | Q54FC8 |
Genome annotation databases
EnsemblProtistsi | EAL61987; EAL61987; DDB_G0290943 |
GeneIDi | 8627910 |
KEGGi | ddi:DDB_G0290943 |
Organism-specific databases
dictyBasei | DDB_G0290943, pks39 |
Phylogenomic databases
eggNOGi | KOG1178, Eukaryota KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_5_1 |
InParanoidi | Q54FC8 |
OMAi | WYLHEAT |
PhylomeDBi | Q54FC8 |
Miscellaneous databases
PROi | PR:Q54FC8 |
Family and domain databases
CDDi | cd05235, SDR_e1, 1 hit |
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013120, Far_NAD-bd IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR010080, Thioester_reductase-like_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF07993, NAD_binding_4, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 3 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS39_DICDI | |
Accessioni | Q54FC8Primary (citable) accession number: Q54FC8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase