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UniProtKB - Q54ER6 (MTND_DICDI)
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Gene
adi1
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
UniRule annotationCatalytic activityi
- 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H+UniRule annotationEC:1.13.11.54UniRule annotation
Cofactori
Fe cationUniRule annotationNote: Binds 1 Fe cation per monomer. Can also use other divalent metal cations.UniRule annotation
: L-methionine biosynthesis via salvage pathway Pathwayi
This protein is involved in step 5 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 74 | Iron or nickelUniRule annotation | 1 | |
Metal bindingi | 76 | Iron or nickelUniRule annotation | 1 | |
Metal bindingi | 80 | Iron or nickelUniRule annotation | 1 | |
Metal bindingi | 119 | Iron or nickelUniRule annotation | 1 |
GO - Molecular functioni
- acireductone dioxygenase [iron(II)-requiring] activity Source: GO_Central
- iron ion binding Source: UniProtKB-UniRule
- oxidoreductase activity Source: dictyBase
GO - Biological processi
- L-methionine salvage from methylthioadenosine Source: dictyBase
- methionine metabolic process Source: GO_Central
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Biological process | Amino-acid biosynthesis, Methionine biosynthesis |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-DDI-1237112, Methionine salvage pathway |
UniPathwayi | UPA00904;UER00878 |
Names & Taxonomyi
Protein namesi | Recommended name: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenaseUniRule annotation (EC:1.13.11.54UniRule annotation)Alternative name(s): Acireductone dioxygenase (Fe(2+)-requiring)UniRule annotation Short name: ARDUniRule annotation Short name: Fe-ARDUniRule annotation |
Gene namesi | Name:adi1 ORF Names:DDB_G0291376 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0291376, adi1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328196 | 1 – 147 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenaseAdd BLAST | 147 |
Proteomic databases
PaxDbi | Q54ER6 |
Family & Domainsi
Sequence similaritiesi
Belongs to the acireductone dioxygenase (ARD) family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG2107, Eukaryota |
HOGENOMi | CLU_090154_1_1_1 |
InParanoidi | Q54ER6 |
OMAi | RGQEDEW |
PhylomeDBi | Q54ER6 |
Family and domain databases
CDDi | cd02232, cupin_ARD, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
HAMAPi | MF_03154, Salvage_MtnD_euk, 1 hit |
InterProi | View protein in InterPro IPR004313, ARD IPR027496, ARD_euk IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR23418, PTHR23418, 1 hit |
Pfami | View protein in Pfam PF03079, ARD, 1 hit |
SUPFAMi | SSF51182, SSF51182, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54ER6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSYFYDNES DVISLDYLKE HNVLYFPMDR EKENYKEPLE TLCKERGYKN
60 70 80 90 100
RDEVKLSKET PGLEDKLKIF FEEHLHDDEE IRFILDGCGF FDIRDKNDKW
110 120 130 140
VKIKEKKGDL IIVPANMYHR FALDESRNIH AMRLFTDAPK WVPINRY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000177 Genomic DNA Translation: EAL61672.1 |
RefSeqi | XP_635174.1, XM_630082.1 |
Genome annotation databases
EnsemblProtistsi | EAL61672; EAL61672; DDB_G0291376 |
GeneIDi | 8628120 |
KEGGi | ddi:DDB_G0291376 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000177 Genomic DNA Translation: EAL61672.1 |
RefSeqi | XP_635174.1, XM_630082.1 |
3D structure databases
SMRi | Q54ER6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0230998 |
Proteomic databases
PaxDbi | Q54ER6 |
Genome annotation databases
EnsemblProtistsi | EAL61672; EAL61672; DDB_G0291376 |
GeneIDi | 8628120 |
KEGGi | ddi:DDB_G0291376 |
Organism-specific databases
dictyBasei | DDB_G0291376, adi1 |
Phylogenomic databases
eggNOGi | KOG2107, Eukaryota |
HOGENOMi | CLU_090154_1_1_1 |
InParanoidi | Q54ER6 |
OMAi | RGQEDEW |
PhylomeDBi | Q54ER6 |
Enzyme and pathway databases
UniPathwayi | UPA00904;UER00878 |
Reactomei | R-DDI-1237112, Methionine salvage pathway |
Miscellaneous databases
PROi | PR:Q54ER6 |
Family and domain databases
CDDi | cd02232, cupin_ARD, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
HAMAPi | MF_03154, Salvage_MtnD_euk, 1 hit |
InterProi | View protein in InterPro IPR004313, ARD IPR027496, ARD_euk IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR23418, PTHR23418, 1 hit |
Pfami | View protein in Pfam PF03079, ARD, 1 hit |
SUPFAMi | SSF51182, SSF51182, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MTND_DICDI | |
Accessioni | Q54ER6Primary (citable) accession number: Q54ER6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families