UniProtKB - Q54EF2 (ANM1_DICDI)
Protein
Protein arginine N-methyltransferase 1
Gene
prmt1
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues present in proteins such as ribonucleoproteins and histones.By similarity
Catalytic activityi
- L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H+ + Nω,Nω-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteineBy similarityEC:2.1.1.319By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | S-adenosyl-L-methionineBy similarity | 1 | |
Binding sitei | 42 | S-adenosyl-L-methionineBy similarity | 1 | |
Binding sitei | 66 | S-adenosyl-L-methionine; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 88 | S-adenosyl-L-methionineBy similarity | 1 | |
Binding sitei | 117 | S-adenosyl-L-methionineBy similarity | 1 | |
Active sitei | 132 | By similarity | 1 | |
Active sitei | 141 | By similarity | 1 |
GO - Molecular functioni
- histone methyltransferase activity Source: UniProtKB
- identical protein binding Source: UniProtKB
- N-methyltransferase activity Source: UniProtKB
- protein-arginine N-methyltransferase activity Source: dictyBase
- protein-arginine omega-N asymmetric methyltransferase activity Source: UniProtKB-EC
- S-adenosyl-L-methionine binding Source: UniProtKB
GO - Biological processi
- mRNA export from nucleus Source: dictyBase
- negative regulation of megakaryocyte differentiation Source: UniProtKB
- peptidyl-arginine modification Source: dictyBase
- protein homooligomerization Source: UniProtKB
- protein methylation Source: UniProtKB
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
Reactomei | R-DDI-3214858 RMTs methylate histone arginines R-DDI-8876725 Protein methylation R-DDI-9018519 Estrogen-dependent gene expression |
Names & Taxonomyi
Protein namesi | Recommended name: Protein arginine N-methyltransferase 1 (EC:2.1.1.319By similarity)Alternative name(s): Histone-arginine N-methyltransferase PRMT1 |
Gene namesi | Name:prmt1 ORF Names:DDB_G0291556 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelids › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0291556 prmt1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328417 | 1 – 341 | Protein arginine N-methyltransferase 1Add BLAST | 341 |
Proteomic databases
PaxDbi | Q54EF2 |
Interactioni
GO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 44689.DDB0235399 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 315 | SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST | 296 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG1499 Eukaryota ENOG410XQYH LUCA |
InParanoidi | Q54EF2 |
KOi | K11434 |
OMAi | CMVKEVD |
PhylomeDBi | Q54EF2 |
Family and domain databases
InterProi | View protein in InterPro IPR025799 Arg_MeTrfase IPR041698 Methyltransf_25 IPR029063 SAM-dependent_MTases |
Pfami | View protein in Pfam PF13649 Methyltransf_25, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51678 SAM_MT_PRMT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54EF2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTETNKNVDA LEKINQMSSA DYYFDSYSHF GIHEEMLKDE VRTLAYRRAI
60 70 80 90 100
INNRKLFEGK VVLDVGCGTG ILCMFAAQAG AKMVIGVDNS EMLPIAQKII
110 120 130 140 150
TANNFDKTIT LIKGKMEEVV LPVDKVDIII SEWMGYFMLY EGMLDTVLYA
160 170 180 190 200
RDKYLVPGGV ILPDKASLYI TAIEDQDYKE EKINYWNNVY GFDMSCIREI
210 220 230 240 250
ALKEPLVDVV QPNMIVTNDC CILTVDIMTI TKDELKFRSD FKLKALRDDL
260 270 280 290 300
IHAFVVYFDI EFSKGDKPVC FSTGPKAKYT HWKQSIMYFE DHIKIQQGEI
310 320 330 340
ITGTMDCAPF DKNQRDLKIK LDFNFAGELM KSSSSLEYHM R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000177 Genomic DNA Translation: EAL61762.1 |
RefSeqi | XP_635288.1, XM_630196.1 |
Genome annotation databases
EnsemblProtistsi | EAL61762; EAL61762; DDB_G0291556 |
GeneIDi | 8628232 |
KEGGi | ddi:DDB_G0291556 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000177 Genomic DNA Translation: EAL61762.1 |
RefSeqi | XP_635288.1, XM_630196.1 |
3D structure databases
SMRi | Q54EF2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0235399 |
Proteomic databases
PaxDbi | Q54EF2 |
Genome annotation databases
EnsemblProtistsi | EAL61762; EAL61762; DDB_G0291556 |
GeneIDi | 8628232 |
KEGGi | ddi:DDB_G0291556 |
Organism-specific databases
dictyBasei | DDB_G0291556 prmt1 |
Phylogenomic databases
eggNOGi | KOG1499 Eukaryota ENOG410XQYH LUCA |
InParanoidi | Q54EF2 |
KOi | K11434 |
OMAi | CMVKEVD |
PhylomeDBi | Q54EF2 |
Enzyme and pathway databases
Reactomei | R-DDI-3214858 RMTs methylate histone arginines R-DDI-8876725 Protein methylation R-DDI-9018519 Estrogen-dependent gene expression |
Miscellaneous databases
PROi | PR:Q54EF2 |
Family and domain databases
InterProi | View protein in InterPro IPR025799 Arg_MeTrfase IPR041698 Methyltransf_25 IPR029063 SAM-dependent_MTases |
Pfami | View protein in Pfam PF13649 Methyltransf_25, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51678 SAM_MT_PRMT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANM1_DICDI | |
Accessioni | Q54EF2Primary (citable) accession number: Q54EF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | May 24, 2005 | |
Last modified: | November 13, 2019 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase