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Entry version 94 (12 Aug 2020)
Sequence version 1 (24 May 2005)
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Protein

Exonuclease 1

Gene

exo1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment (By similarity).By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi30Magnesium 1By similarity1
Metal bindingi78Magnesium 1By similarity1
Metal bindingi150Magnesium 1By similarity1
Metal bindingi152Magnesium 1By similarity1
Metal bindingi171Magnesium 2By similarity1
Metal bindingi173Magnesium 2By similarity1
Metal bindingi228Magnesium 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Endonuclease, Excision nuclease, Exonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA excision, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-5358565, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-DDI-5685938, HDR through Single Strand Annealing (SSA)
R-DDI-5693607, Processing of DNA double-strand break ends
R-DDI-5693616, Presynaptic phase of homologous DNA pairing and strand exchange

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exonuclease 1 (EC:3.1.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:exo1
ORF Names:DDB_G0291570
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0291570, exo1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003285601 – 1046Exonuclease 1Add BLAST1046

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54ED2

PRoteomics IDEntifications database

More...
PRIDEi
Q54ED2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the mlh1-pms2 heterodimer via mlh1.

Interacts with msh3.

Interacts with the msh2-msh6 heterodimer via msh2, and this interaction may increase the processivity of the 5'->3' exonuclease activity (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0232997

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54ED2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 99N-domainBy similarityAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi309 – 316Poly-Asn8
Compositional biasi398 – 406Poly-Asn9
Compositional biasi449 – 461Poly-ThrAdd BLAST13
Compositional biasi463 – 467Poly-Asn5
Compositional biasi548 – 555Poly-Glu8
Compositional biasi764 – 772Poly-Asn9
Compositional biasi775 – 789Poly-AsnAdd BLAST15
Compositional biasi895 – 947Poly-AsnAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2518, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_291785_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54ED2

KEGG Orthology (KO)

More...
KOi
K10746

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLRQMCI

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09908, H3TH_EXO1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036279, 5-3_exonuclease_C_sf
IPR032641, Exo1
IPR037315, EXO1_H3TH
IPR008918, HhH2
IPR029060, PIN-like_dom_sf
IPR019734, TPR_repeat
IPR006086, XPG-I_dom
IPR006084, XPG/Rad2
IPR006085, XPG_DNA_repair_N

The PANTHER Classification System

More...
PANTHERi
PTHR11081, PTHR11081, 1 hit
PTHR11081:SF8, PTHR11081:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00867, XPG_I, 1 hit
PF00752, XPG_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00853, XPGRADSUPER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00279, HhH2, 1 hit
SM00484, XPGI, 1 hit
SM00485, XPGN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47807, SSF47807, 1 hit
SSF88723, SSF88723, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54ED2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGISGLLPAL SPVTKAIHVK DYANKRVAID GYSWLHKGAY SCSQEIVLGI
60 70 80 90 100
PTRNYINYFI SRIKMLISYK VIPVVIFDGG PLPNKKLKEQ ERLRHREEYK
110 120 130 140 150
NKAKAYLLEG NKSQANICFQ KAVDITPRMA FLLIKELRAL KVEYLVAPYE
160 170 180 190 200
ADAQLTYLSI TGQVDAIITE DSDLVAFGAT HIIFKMDKYG YAQEIKTEDL
210 220 230 240 250
GSCKKDGYDF IDFNQTMLRQ MCILSGCDYL PSLSGMGLKT SFKLLKQHRD
260 270 280 290 300
IEKVFKYLKR EKSNFSQEYE QQFYKADFTF KHQRVFDPVS RILTTLLPLP
310 320 330 340 350
TIIDSRFLND NNNNTNDGDS NGDGSSGGSG SGGGFLDFIG PVIDDEIAEK
360 370 380 390 400
IALGIIDPET HEQFDKTQPY PKNTFTPQPK KLLSPISFNT KEFKNQTNNN
410 420 430 440 450
NNNNNNIKSN NGTNNKNGMI LNEGKLVQKG RNLNDQFTFA SNKITQYMTT
460 470 480 490 500
TTTTTTTTTT TKNNNNNQKQ QPMIEDDTGY DFQIDSFEID DCLNDDDDDE
510 520 530 540 550
SIILSNNLNN QENVLESDCE FDDDDDQRGI DVDDSEKKDS FVLDSDYEDE
560 570 580 590 600
KEEEEVKSST FNSSSSISSG NSSKIKKTLV SSKFFVSSES SVLESDDDDG
610 620 630 640 650
GDDDDDSFNH NQNFSSSGNN IQPNSNIFHN GELSSYGYQK NQKNFKNVNS
660 670 680 690 700
NSSSNSSNSS NSSSGNSNSG NRIFNSGNSS NKNNTNGGIV KSTLLSSNDR
710 720 730 740 750
VSLNFFDQFQ FDGKKKQSIL VSQSRKSFSS PTLSNNEDYD SSFVSSTIPS
760 770 780 790 800
SIGDDYDQMN SCSNNNNFNY NNSSNFNNNN INNSNNNRNS GFSGFLKRKS
810 820 830 840 850
SSQTAAPTTP TTPTTPKTSS SSSSTLTNST ITTEHSSYIL KKPKYQATSN
860 870 880 890 900
SPISTLDSSQ NYNDQSFISK KAHSFSSLDS DLIFKEDDVD NLIFNNNNNN
910 920 930 940 950
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNDNNNKIT
960 970 980 990 1000
TPSNKSFNSI VLTTTSATTS ITQQDNEIYT TPKKKLPSTP ISSSSNDIIS
1010 1020 1030 1040
KYFSSPSKVG PKSEGAPPTP VNLEGMSLRS VLSLRYQQTM ASSPTK
Length:1,046
Mass (Da):116,366
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AD1618AC14E5C08
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000177 Genomic DNA Translation: EAL61769.1

NCBI Reference Sequences

More...
RefSeqi
XP_635308.1, XM_630216.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL61769; EAL61769; DDB_G0291570

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8628252

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0291570

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000177 Genomic DNA Translation: EAL61769.1
RefSeqiXP_635308.1, XM_630216.1

3D structure databases

SMRiQ54ED2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232997

Proteomic databases

PaxDbiQ54ED2
PRIDEiQ54ED2

Genome annotation databases

EnsemblProtistsiEAL61769; EAL61769; DDB_G0291570
GeneIDi8628252
KEGGiddi:DDB_G0291570

Organism-specific databases

dictyBaseiDDB_G0291570, exo1

Phylogenomic databases

eggNOGiKOG2518, Eukaryota
HOGENOMiCLU_291785_0_0_1
InParanoidiQ54ED2
KOiK10746
OMAiMLRQMCI

Enzyme and pathway databases

ReactomeiR-DDI-5358565, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-DDI-5685938, HDR through Single Strand Annealing (SSA)
R-DDI-5693607, Processing of DNA double-strand break ends
R-DDI-5693616, Presynaptic phase of homologous DNA pairing and strand exchange

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54ED2

Family and domain databases

CDDicd09908, H3TH_EXO1, 1 hit
InterProiView protein in InterPro
IPR036279, 5-3_exonuclease_C_sf
IPR032641, Exo1
IPR037315, EXO1_H3TH
IPR008918, HhH2
IPR029060, PIN-like_dom_sf
IPR019734, TPR_repeat
IPR006086, XPG-I_dom
IPR006084, XPG/Rad2
IPR006085, XPG_DNA_repair_N
PANTHERiPTHR11081, PTHR11081, 1 hit
PTHR11081:SF8, PTHR11081:SF8, 1 hit
PfamiView protein in Pfam
PF00867, XPG_I, 1 hit
PF00752, XPG_N, 1 hit
PRINTSiPR00853, XPGRADSUPER
SMARTiView protein in SMART
SM00279, HhH2, 1 hit
SM00484, XPGI, 1 hit
SM00485, XPGN, 1 hit
SUPFAMiSSF47807, SSF47807, 1 hit
SSF88723, SSF88723, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXO1_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54ED2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: August 12, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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