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Entry version 90 (29 Sep 2021)
Sequence version 1 (24 May 2005)
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Protein

Alpha-protein kinase 1

Gene

ak1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1164 – 1169ATPSequence analysis6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-protein kinase 1 (EC:2.7.11.-)
Short name:
AK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ak1
ORF Names:DDB_G0292150
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0292150, ak1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003639221 – 1352Alpha-protein kinase 1Add BLAST1352

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54DK4

PRoteomics IDEntifications database

More...
PRIDEi
Q54DK4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0220120

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54DK4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 127Arf-GAPPROSITE-ProRule annotationAdd BLAST121
Domaini990 – 1194Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST205

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni123 – 164DisorderedSequence analysisAdd BLAST42
Regioni219 – 380DisorderedSequence analysisAdd BLAST162
Regioni424 – 445DisorderedSequence analysisAdd BLAST22
Regioni457 – 484DisorderedSequence analysisAdd BLAST28
Regioni503 – 560DisorderedSequence analysisAdd BLAST58
Regioni619 – 658DisorderedSequence analysisAdd BLAST40
Regioni786 – 863DisorderedSequence analysisAdd BLAST78
Regioni901 – 979DisorderedSequence analysisAdd BLAST79
Regioni1198 – 1234DisorderedSequence analysisAdd BLAST37
Regioni1279 – 1352DisorderedSequence analysisAdd BLAST74

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili393 – 429Sequence analysisAdd BLAST37
Coiled coili689 – 781Sequence analysisAdd BLAST93
Coiled coili1241 – 1320Sequence analysisAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi262 – 323Polar residuesSequence analysisAdd BLAST62
Compositional biasi331 – 380Polar residuesSequence analysisAdd BLAST50
Compositional biasi468 – 484Polar residuesSequence analysisAdd BLAST17
Compositional biasi526 – 560Polar residuesSequence analysisAdd BLAST35
Compositional biasi619 – 642Polar residuesSequence analysisAdd BLAST24
Compositional biasi905 – 934Pro residuesSequence analysisAdd BLAST30
Compositional biasi935 – 979Polar residuesSequence analysisAdd BLAST45
Compositional biasi1218 – 1234Polar residuesSequence analysisAdd BLAST17
Compositional biasi1279 – 1321Polar residuesSequence analysisAdd BLAST43

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 48C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0703, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_257642_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54DK4

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEDRMVY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.220.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037278, ARFGAP/RecO
IPR001164, ArfGAP_dom
IPR038508, ArfGAP_dom_sf
IPR011009, Kinase-like_dom_sf
IPR004166, MHCK_EF2_kinase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02816, Alpha_kinase, 1 hit
PF01412, ArfGap, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00811, Alpha_kinase, 1 hit
SM00105, ArfGap, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit
SSF57863, SSF57863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51158, ALPHA_KINASE, 1 hit
PS50115, ARFGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54DK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPVPSDPNY GLLRSLFQDP NNQCCAECNS ANVPYVCIKL GVFICPTCAH
60 70 80 90 100
FLSTLGFKVR PIMGSSFSEE DISRLQSIGN LVSKQFWLAR WTPMDIVMPP
110 120 130 140 150
PEDPNLESFL RLKYIEKRWT SSLSTSDGFS SPNNNNTSNV NNINNNSNHN
160 170 180 190 200
NNINNNNNNI NNNNNNNINN NNNIINNFSN INNISNGMNN ISLNNINNNN
210 220 230 240 250
NNNNHYNGND IGIPIVHKTQ SQPQPQPQPQ PQPQSQGFSP FNSPRSSPKP
260 270 280 290 300
GRHHLIDDLI SFNPTPVNNS NNNNNNNNNN NNGNNGNPLK FSGGIPQNNN
310 320 330 340 350
NNNNNNTTTT TTTTNNNNKV PFDPFSPIKT FSESGEYQNT NGNQQLSGSG
360 370 380 390 400
NSLIDILSHP TQSKSPSPSG TPHSLSPQHH SSDFKVHLID IPTTQQQLQQ
410 420 430 440 450
QQLQLQQQLQ QQLQQQQQQQ QQQQQQQQSP ISNPFTSNNN SNSEPLVSIL
460 470 480 490 500
DKHEDLHNHH HHQQQQHHKQ QQQQQQQQQN GNNSPLAQFN QIQQQQINNN
510 520 530 540 550
NPFVEEKQPH QHPHHLQHHR HHSTSSINHG SNGDLASISL TLLTPSPSPS
560 570 580 590 600
PSFNYSGGVS SAPNNSLNNS CNGNNNLNNG MLNFSNLNIG GSTSSACSTN
610 620 630 640 650
SSSNITIANN INSSNNINII NNQNNQNNNN NNNTNNVMIS PSPSPNPFLP
660 670 680 690 700
TPTSTNQNNH IITPIPVNPF TDNLQLNSNN IRQHPQQMYI QQQQQQQQQQ
710 720 730 740 750
QQQQQQQQQQ QQQQQQQQLQ MQQQQQQQMQ QHYQQQQQQQ QQQQQQQQQQ
760 770 780 790 800
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQHIN LSSSAPLQSV NHSPIPLQPQ
810 820 830 840 850
HSSSQYMNQQ GYQVYPNVGN QPQSPQQIQP QPLQQQIFQQ VQQQQPQIPQ
860 870 880 890 900
QSPQPLQSST DEDQSVLEVL NLKKLFDMNM MDKEEFEHRR RQIIDNLTKT
910 920 930 940 950
TSPIHQQPPQ PPQPVLPVSA PAQVPQPHPP QQQNGPTVPQ QQQQQQQQQQ
960 970 980 990 1000
QQQQQQQQQQ QQQQPIPQPS SSSPTPDARL TGTERVIRHR FDAKLGKWVQ
1010 1020 1030 1040 1050
TATIVITEPT PFAEGAMRKA FRMKDLSAEG PSSQMVAKLF KDSNEDRMVY
1060 1070 1080 1090 1100
FKDVEMQTYS KEIAERFNLK SPPKKIDFVP AFVMELVERQ GKPFCAVEYF
1110 1120 1130 1140 1150
IEGKYEKHNN NFGYKNDYDR NTPQAFSHFS YEDSGCQLIV VDIQGVGDVY
1160 1170 1180 1190 1200
TDPQIHSADG QGFGKGNLGI EGIKRFFSTH QCNPICHYLG LSSVNPKPAN
1210 1220 1230 1240 1250
DESGTMPRPP SIGQSYVRPS AFPPNLQQSF SFNFPPLKDH HVLEQLNQQQ
1260 1270 1280 1290 1300
QHLQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQNQQQNQ
1310 1320 1330 1340 1350
QQNQQQQQQQ QQQQQQQQNG HPPPQTPLPP TPQQKDKPKI EVFGDILRKL

VS
Length:1,352
Mass (Da):154,085
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A18FD3142AC0DE1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000187 Genomic DNA Translation: EAL61431.1

NCBI Reference Sequences

More...
RefSeqi
XP_629868.1, XM_629866.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL61431; EAL61431; DDB_G0292150

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8628550

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0292150

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000187 Genomic DNA Translation: EAL61431.1
RefSeqiXP_629868.1, XM_629866.1

3D structure databases

SMRiQ54DK4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0220120

Proteomic databases

PaxDbiQ54DK4
PRIDEiQ54DK4

Genome annotation databases

EnsemblProtistsiEAL61431; EAL61431; DDB_G0292150
GeneIDi8628550
KEGGiddi:DDB_G0292150

Organism-specific databases

dictyBaseiDDB_G0292150, ak1

Phylogenomic databases

eggNOGiKOG0703, Eukaryota
HOGENOMiCLU_257642_0_0_1
InParanoidiQ54DK4
OMAiNEDRMVY

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54DK4

Family and domain databases

Gene3Di1.10.220.150, 1 hit
InterProiView protein in InterPro
IPR037278, ARFGAP/RecO
IPR001164, ArfGAP_dom
IPR038508, ArfGAP_dom_sf
IPR011009, Kinase-like_dom_sf
IPR004166, MHCK_EF2_kinase
PfamiView protein in Pfam
PF02816, Alpha_kinase, 1 hit
PF01412, ArfGap, 1 hit
SMARTiView protein in SMART
SM00811, Alpha_kinase, 1 hit
SM00105, ArfGap, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
SSF57863, SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS51158, ALPHA_KINASE, 1 hit
PS50115, ARFGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAK1_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54DK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: September 29, 2021
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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