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Entry version 107 (25 May 2022)
Sequence version 1 (24 May 2005)
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Protein

ATP-dependent RNA helicase ddx54

Gene

helA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-binding RNA helicase which may be involved in the ribosome biogenesis.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi274 – 281ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • rRNA processing Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRibosome biogenesis, rRNA processing
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent RNA helicase ddx54 (EC:3.6.4.13)
Alternative name(s):
ATP-dependent RNA helicase helA
DEAD box protein 54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:helA
Synonyms:ddx54
ORF Names:DDB_G0292992
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0292992, helA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003274381 – 1091ATP-dependent RNA helicase ddx54Add BLAST1091

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54CD8

PRoteomics IDEntifications database

More...
PRIDEi
Q54CD8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0215372

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q54CD8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54CD8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini261 – 433Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST173
Domaini478 – 632Helicase C-terminalPROSITE-ProRule annotationAdd BLAST155

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 63DisorderedSequence analysisAdd BLAST63
Regioni150 – 231DisorderedSequence analysisAdd BLAST82
Regioni801 – 896DisorderedSequence analysisAdd BLAST96
Regioni933 – 1091DisorderedSequence analysisAdd BLAST159

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi230 – 258Q motifAdd BLAST29
Motifi381 – 384DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 36Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi37 – 52Polar residuesSequence analysisAdd BLAST16
Compositional biasi169 – 231Basic and acidic residuesSequence analysisAdd BLAST63
Compositional biasi807 – 823Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi824 – 853Acidic residuesSequence analysisAdd BLAST30
Compositional biasi854 – 882Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi933 – 994Basic and acidic residuesSequence analysisAdd BLAST62
Compositional biasi1004 – 1056Basic and acidic residuesSequence analysisAdd BLAST53

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0337, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003041_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54CD8

Identification of Orthologs from Complete Genome Data

More...
OMAi
MRWDKKS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54CD8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012541, DBP10_C
IPR033517, DDX54/DBP10
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000629, RNA-helicase_DEAD-box_CS
IPR014014, RNA_helicase_DEAD_Q_motif

The PANTHER Classification System

More...
PANTHERi
PTHR24031:SF292, PTHR24031:SF292, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08147, DBP10CT, 1 hit
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01123, DBP10CT, 1 hit
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00039, DEAD_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51195, Q_MOTIF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54CD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKPNNVKIK NKGNLKKSNE SQNDYMKGKK LETKSYQKAL LSKNSNNNND
60 70 80 90 100
GAQAKRLKKK EEFKKKLEKR QNTIVIKDKL KEPSTFLKED QSFFDQNIFN
110 120 130 140 150
DQDDYKHQQM NRININENFE TNLFGDMMNE FDGDLNEDLD LLDYNDEVID
160 170 180 190 200
NSNFDNNGDQ FNSEDEEFYD DEKQAKKSNK NKNADADNKK SKKSNKKEEI
210 220 230 240 250
ESSEKFESFP MDENNEQEEE TTSKKKKKTG GFQSMDLTKN LLKAILKKGF
260 270 280 290 300
NVPTPIQRKS IPMILDGHDI VGMARTGSGK TGAFVIPMIQ KLGDHSTTVG
310 320 330 340 350
VRAVILSPTR ELAIQTFKVV KDFSQGTQLR TILIVGGDSM EDQFTDLARN
360 370 380 390 400
PDIIIATPGR LMHHLLETGM SLSKVQYIVF DEADRLFEMG FNEQLTEILS
410 420 430 440 450
KLSENRQTLL FSATLPSLLV DFVRAGLNNP KLINLDTDTK ISENLSLSFF
460 470 480 490 500
TLRHEEKLGV LLFLLKDIIY KKPQLPTTET TTTTTTNNES NQQQQKKSST
510 520 530 540 550
IIFVSTKYHV EFIHILLERA GIASTYIHGY LDPVARKINL AKFRSHQVGV
560 570 580 590 600
MVVTDLAARG IDIPLLDNVI NFDFPPKEKI FIHRVGRVAR AGRSGIAYSL
610 620 630 640 650
VSPDEVPYMI DLHLYLGRKF LNKFQYEGQT INDPKYSFYG TIPQTIIDRE
660 670 680 690 700
TEFVNVQRKE CIELLSLTKT IHNAHKKYLS TRPGASHESN RRAKLMDKSK
710 720 730 740 750
YHPMLSDHLN SNDQIRNDFI QSLKSFRPPQ TVLELDARKN NVQVSIMKDK
760 770 780 790 800
RKVHTNVIES QQKKLYLQQS ETNLGPENEE FDYSKLDTRK RLLQLTENIT
810 820 830 840 850
EEMLRSNKSN DNNDNNKDIK MNENDDENDD DDEEGENDDD EEEENEKDED
860 870 880 890 900
DEEDENKNKF NIKIESSDKN DNNKKKLKSR SSSRDPNFFI SATPENLIQE
910 920 930 940 950
RAMSISNRFT KDDEVNLVAD TDRKQKKSMV WDKRKGKFVS SQADADRKNS
960 970 980 990 1000
KKLVRNEAGK LVEAKKSHKG YEEWKKKTHG RIQRVGEDEN SKYQPNQKEY
1010 1020 1030 1040 1050
LPQKWRGQGR EKEKKDNKAS HAKGSHGLKG RPSELKDKNQ ISKNRSEKER
1060 1070 1080 1090
KMRVNKTKGN PKGSKSKSGG GGGGKGSKFG SGKSKGGKSR K
Length:1,091
Mass (Da):125,085
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23F859D1A9D1D231
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti344 – 345FT → LH in CAA57416 (PubMed:7695838).Curated2
Sequence conflicti350N → Y in CAA57416 (PubMed:7695838).Curated1
Sequence conflicti355I → L in CAA57416 (PubMed:7695838).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000199 Genomic DNA Translation: EAL60848.1
X81822 Genomic DNA Translation: CAA57416.1

NCBI Reference Sequences

More...
RefSeqi
XP_629281.1, XM_629279.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL60848; EAL60848; DDB_G0292992

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8629004

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0292992

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000199 Genomic DNA Translation: EAL60848.1
X81822 Genomic DNA Translation: CAA57416.1
RefSeqiXP_629281.1, XM_629279.1

3D structure databases

AlphaFoldDBiQ54CD8
SMRiQ54CD8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0215372

Proteomic databases

PaxDbiQ54CD8
PRIDEiQ54CD8

Genome annotation databases

EnsemblProtistsiEAL60848; EAL60848; DDB_G0292992
GeneIDi8629004
KEGGiddi:DDB_G0292992

Organism-specific databases

dictyBaseiDDB_G0292992, helA

Phylogenomic databases

eggNOGiKOG0337, Eukaryota
HOGENOMiCLU_003041_5_2_1
InParanoidiQ54CD8
OMAiMRWDKKS
PhylomeDBiQ54CD8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54CD8

Family and domain databases

Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR012541, DBP10_C
IPR033517, DDX54/DBP10
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000629, RNA-helicase_DEAD-box_CS
IPR014014, RNA_helicase_DEAD_Q_motif
PANTHERiPTHR24031:SF292, PTHR24031:SF292, 1 hit
PfamiView protein in Pfam
PF08147, DBP10CT, 1 hit
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
SMARTiView protein in SMART
SM01123, DBP10CT, 1 hit
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00039, DEAD_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51195, Q_MOTIF, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDX54_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54CD8
Secondary accession number(s): Q23908
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 25, 2022
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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