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Protein

Probable replication factor C subunit 3

Gene

rfc3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1.By similarity

GO - Molecular functioni

GO - Biological processi

  • DNA-dependent DNA replication Source: GO_Central
  • leading strand elongation Source: dictyBase

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-DDI-174411 Polymerase switching on the C-strand of the telomere
R-DDI-176187 Activation of ATR in response to replication stress
R-DDI-5655862 Translesion synthesis by POLK
R-DDI-5656169 Termination of translesion DNA synthesis
R-DDI-6782135 Dual incision in TC-NER
R-DDI-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DDI-69091 Polymerase switching

Names & Taxonomyi

Protein namesi
Recommended name:
Probable replication factor C subunit 3
Alternative name(s):
Activator 1 subunit 3
Gene namesi
Name:rfc3
ORF Names:DDB_G0293702
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0293702 rfc3

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003275611 – 347Probable replication factor C subunit 3Add BLAST347

Proteomic databases

PaxDbiQ54BN3
PRIDEiQ54BN3

Interactioni

Subunit structurei

Heteropentamer of various rfc subunits that forms a complex (RFC) with PCNA in the presence of ATP.

Protein-protein interaction databases

STRINGi44689.DDB0232232

Structurei

3D structure databases

ProteinModelPortaliQ54BN3
SMRiQ54BN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the activator 1 small subunits family.Curated

Phylogenomic databases

eggNOGiKOG2035 Eukaryota
COG0470 LUCA
InParanoidiQ54BN3
KOiK10756
OMAiLSHCIPP
PhylomeDBiQ54BN3

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR008921 DNA_pol3_clamp-load_cplx_C
IPR027417 P-loop_NTPase
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF48019 SSF48019, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q54BN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLWIDKYKPT SLDKMDYHND ISINLKNMIK SGDFPHLLVY GPSGAGKKTR
60 70 80 90 100
ILAVLQEIYG PNALKLKIDH RTFKHPTSSK NIQITTISSH YHIEINPGEA
110 120 130 140 150
GSYDRVVIQT IIKEIAQSPP IDSGSLGAFK IVILNEVDKL SKDAQHALRR
160 170 180 190 200
TMEKYATFCR LILCCDSTAK VIDPIKSRCL GIRVPAPSQE EIEKVLAKVA
210 220 230 240 250
TAEKFDLPSK LAVNVAKQSG GNLRYALMLL ESQKAKQYPF QSTELPLLDW
260 270 280 290 300
ENYISQIVKD CFEEQSPARL SIVRGKLYEL LGHCIPPELI FKTLLLEIFK
310 320 330 340
KLDHNMKFEI IHWASYYEHR SQIGSKPIFH LEAFIAKFMS VYKKYNQ
Length:347
Mass (Da):39,551
Last modified:May 24, 2005 - v1
Checksum:i65D92D347D6A7EC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000218 Genomic DNA Translation: EAL60663.1
RefSeqiXP_628996.1, XM_628994.1

Genome annotation databases

EnsemblProtistsiEAL60663; EAL60663; DDB_G0293702
GeneIDi8629280
KEGGiddi:DDB_G0293702

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000218 Genomic DNA Translation: EAL60663.1
RefSeqiXP_628996.1, XM_628994.1

3D structure databases

ProteinModelPortaliQ54BN3
SMRiQ54BN3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232232

Proteomic databases

PaxDbiQ54BN3
PRIDEiQ54BN3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL60663; EAL60663; DDB_G0293702
GeneIDi8629280
KEGGiddi:DDB_G0293702

Organism-specific databases

dictyBaseiDDB_G0293702 rfc3

Phylogenomic databases

eggNOGiKOG2035 Eukaryota
COG0470 LUCA
InParanoidiQ54BN3
KOiK10756
OMAiLSHCIPP
PhylomeDBiQ54BN3

Enzyme and pathway databases

ReactomeiR-DDI-174411 Polymerase switching on the C-strand of the telomere
R-DDI-176187 Activation of ATR in response to replication stress
R-DDI-5655862 Translesion synthesis by POLK
R-DDI-5656169 Termination of translesion DNA synthesis
R-DDI-6782135 Dual incision in TC-NER
R-DDI-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DDI-69091 Polymerase switching

Miscellaneous databases

PROiPR:Q54BN3

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR008921 DNA_pol3_clamp-load_cplx_C
IPR027417 P-loop_NTPase
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF48019 SSF48019, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFC3_DICDI
AccessioniPrimary (citable) accession number: Q54BN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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