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Protein

Signal transducer and activator of transcription C

Gene

dstC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi662 – 706By similarityAdd BLAST45

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription C
Alternative name(s):
Dd-STATc
STAT5 homolog C
Gene namesi
Name:dstC
Synonyms:statC
ORF Names:DDB_G0293532
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0293532 dstC

Subcellular locationi

  • Cytoplasm
  • Nucleus
  • Note: Tyrosine phosphorylation is not required for translocation to the nucleus. DIF inhibits export from the nucleus. Predominantly nuclear in pstO cells at the rear of the prestalk region in the slug. Subject to crm1-dependent nuclear export.

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Cells display abnormal regulation of gene expression and aberrant timing of development. Colonies growing on a bacterial lawn are smaller, have a rough edge and are surrounded by satellite fruiting bodies.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi7 – 9KKR → AAA: No effect on nuclear import. 1 Publication3
Mutagenesisi924Y → F: Loss of activity. Has no effect on DIF-induced translocation to the nucleus. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003280831 – 931Signal transducer and activator of transcription CAdd BLAST931

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei924Phosphotyrosine1 Publication1

Post-translational modificationi

Tyrosine phosphorylated in response to the chlorinated hexaphenone DIF. Minimally phosphorylated in the absence of DIF. Phosphorylation increases during development, is highest during the slug stage, with a strong decrease at culmination.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ54BD4

PTM databases

iPTMnetiQ54BD4

Expressioni

Developmental stagei

Constitutively expressed during development (at protein level).1 Publication

Inductioni

Up-regulated in response to hyperosmotic shock.1 Publication

Interactioni

Subunit structurei

Monomer, in the absence of tyrosine phosphorylation. Homodimer, or heterodimer with another family member, when tyrosine phosphorylated.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0215378

Structurei

3D structure databases

ProteinModelPortaliQ54BD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini802 – 931SH2PROSITE-ProRule annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 46Mediates DIF-inducible nuclear importAdd BLAST41
Regioni504 – 554Mediates nuclear exportAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili471 – 577Sequence analysisAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi112 – 144Poly-AsnAdd BLAST33
Compositional biasi198 – 203Poly-Gln6
Compositional biasi222 – 251Poly-GlnAdd BLAST30
Compositional biasi258 – 296Poly-GlnAdd BLAST39
Compositional biasi299 – 332Poly-GlnAdd BLAST34
Compositional biasi405 – 417Poly-AsnAdd BLAST13
Compositional biasi447 – 450Poly-Asn4

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

Coiled coil, SH2 domain

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
InParanoidiQ54BD4
OMAiIVITNEC

Family and domain databases

Gene3Di2.60.40.340, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR037059 RHD_DNA_bind_dom_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR015988 STAT_TF_coiled-coil
IPR015347 STAT_TF_homologue_coiled-coil
PANTHERiPTHR11801 PTHR11801, 2 hits
PfamiView protein in Pfam
PF09267 Dict-STAT-coil, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q54BD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNNNPKKRP LDAISNTFEV KQEEPEFSSD GFNTTNDDLM SLMTFLDNGT
60 70 80 90 100
GQQNQQNQQN QQPQPQPQPQ PQLPQPQSQQ PIYNSNTTTV TVKTEGIATS
110 120 130 140 150
PLSNASSPIS TNNNINNNTN NNNNNNNNNN NNNNNNNNNN NNINTATPPA
160 170 180 190 200
IGVQQNSNIP YSYPIYTDVT GQQTQHQQNI GQNSVNIDPY FQTIDGAQIQ
210 220 230 240 250
QQQLLQQQLQ PIQQVNNPQI DQAQIQQQQA QQIQQQQAQI QAQQAQIQQQ
260 270 280 290 300
QLEQQHLQQQ QFQFQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQHHQQ
310 320 330 340 350
QQQQQQHQQQ QQHQQQQQHQ QHQQQQHQQH QQIHQNHQNQ LNHQNQLNNQ
360 370 380 390 400
NQLNNQNQLN NQNQLNHQNQ LNQPTQPQMQ QIELPILHQL PVEPQHLHPI
410 420 430 440 450
PTHINNNGNN NNNNNNNGSN SSNSSNGIGS PDDIIEPNIL SSIQHCNNNN
460 470 480 490 500
LPLPDHLLIN TPYGNVLQPH QQIINECLKL HLAQKEQLDK MKIVQKQVLA
510 520 530 540 550
HPQKETFQML DNEQNTLKKQ IDAEITSLQQ IDQTFVLSPP EIRNVIFLLH
560 570 580 590 600
ELTIQSIQLE LYHEELQLLV RPQNPPPTIA ALVVIEQPFP MVITKCKPLE
610 620 630 640 650
DDPVVVQLLC GTRTELQMIG KVRATMIVEN QQGSKTSSSP KTIETEVVSM
660 670 680 690 700
DETNRLAKYH LKFLNGTRKN PVTLKFGMQV QVVGGTAVNI ESPPTSPFIV
710 720 730 740 750
ITNECQYEES DGTLLKKDSF GNNNEIPWAS YANKLQRHFL RATRQDFMKP
760 770 780 790 800
TRYLSRHELM YIHHQFFGSK PMIPQSSFDS FWIWFGKGLQ KLRYQRHVCS
810 820 830 840 850
MWQSGLIYGF ISRQSVEEAL RNEEQGTFLI RFSERHAGHF AVGYKVDDPD
860 870 880 890 900
PEKRIRHYLV KADDTAGAKK TLPDFLSECP QFTKILQLTI DVSTGEPRLR
910 920 930
NFPKDVVLEP YYSKRETLPA TNGYDSLPTI L
Length:931
Mass (Da):107,204
Last modified:May 24, 2005 - v1
Checksum:i16C6D75D30812B32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116N → Y in CAC33514 (PubMed:11336701).Curated1
Sequence conflicti119T → TN in CAC33514 (PubMed:11336701).Curated1
Sequence conflicti143I → N in CAC33514 (PubMed:11336701).Curated1
Sequence conflicti334 – 336Missing in CAC33514 (PubMed:11336701).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ301670 mRNA Translation: CAC33514.1
AAFI02000218 Genomic DNA Translation: EAL60578.1
RefSeqiXP_629095.1, XM_629093.1

Genome annotation databases

EnsemblProtistsiEAL60578; EAL60578; DDB_G0293532
GeneIDi8629388
KEGGiddi:DDB_G0293532

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ301670 mRNA Translation: CAC33514.1
AAFI02000218 Genomic DNA Translation: EAL60578.1
RefSeqiXP_629095.1, XM_629093.1

3D structure databases

ProteinModelPortaliQ54BD4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0215378

PTM databases

iPTMnetiQ54BD4

Proteomic databases

PaxDbiQ54BD4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL60578; EAL60578; DDB_G0293532
GeneIDi8629388
KEGGiddi:DDB_G0293532

Organism-specific databases

dictyBaseiDDB_G0293532 dstC

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
InParanoidiQ54BD4
OMAiIVITNEC

Miscellaneous databases

PROiPR:Q54BD4

Family and domain databases

Gene3Di2.60.40.340, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR037059 RHD_DNA_bind_dom_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR015988 STAT_TF_coiled-coil
IPR015347 STAT_TF_homologue_coiled-coil
PANTHERiPTHR11801 PTHR11801, 2 hits
PfamiView protein in Pfam
PF09267 Dict-STAT-coil, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTATC_DICDI
AccessioniPrimary (citable) accession number: Q54BD4
Secondary accession number(s): Q9BLX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 12, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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Main funding by: National Institutes of Health

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