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Protein

Probable serine/threonine-protein kinase dyrk2

Gene

dyrk2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei634ATPPROSITE-ProRule annotation1
Active sitei731Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi611 – 619ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase dyrk2 (EC:2.7.12.1)
Alternative name(s):
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Gene namesi
Name:dyrk2
ORF Names:DDB_G0293750
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0293750 dyrk2

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003620101 – 915Probable serine/threonine-protein kinase dyrk2Add BLAST915

Proteomic databases

PaxDbiQ54BC9
PRIDEiQ54BC9

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0230102

Structurei

3D structure databases

ProteinModelPortaliQ54BC9
SMRiQ54BC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini605 – 902Protein kinasePROSITE-ProRule annotationAdd BLAST298

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 64Poly-Asn7
Compositional biasi65 – 77Poly-ThrAdd BLAST13
Compositional biasi170 – 182Poly-SerAdd BLAST13
Compositional biasi194 – 204Poly-SerAdd BLAST11
Compositional biasi207 – 210Poly-Asn4
Compositional biasi295 – 298Poly-Pro4
Compositional biasi299 – 302Poly-Ser4
Compositional biasi303 – 318Poly-ThrAdd BLAST16
Compositional biasi319 – 325Poly-Ser7
Compositional biasi378 – 391Poly-SerAdd BLAST14
Compositional biasi439 – 445Poly-Thr7
Compositional biasi448 – 462Poly-SerAdd BLAST15
Compositional biasi466 – 472Poly-Ser7
Compositional biasi488 – 499Poly-ThrAdd BLAST12
Compositional biasi514 – 531Poly-ThrAdd BLAST18

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
InParanoidiQ54BC9
KOiK18669
OMAiQKKTHRR

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q54BC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLHKQIIE SHNNDITKLK SSMSTRAAAR RSVCLSSMSY TLGADDVTPI
60 70 80 90 100
TSNTTPSNNN NNNNTTTTIT TTTTTPTISP LKQSTTGSII PKSILVTKSG
110 120 130 140 150
SKEEPIVSSS KSSSNSSSIN NNFNNLYSAS TFSSSTKKVH ERPSINPGFR
160 170 180 190 200
KPREALLSGN SDSGIIKKPS SSSTSSSSSS SSTTSNIKAP IQISHSSNSG
210 220 230 240 250
SSSSGGNNNN SDDNSGSSTI KHTAASLSKM KLSPSHTISD SPRSSTMKSR
260 270 280 290 300
SVSISNGSLF SPTNTSVNNS NNNTSSNIKT PTKSSISENL DQNTPPPPSS
310 320 330 340 350
SSTTKTPTAT TTTTTTTTSS SSSTSTNTTP SKSSVDDVFA RLANVSKPAI
360 370 380 390 400
KSRSLSVSAS LARVEQSPPT KDKGDKESSS SSSSSSSSFS SKFTKILRSS
410 420 430 440 450
SKTPTPTSSN TTVQPSTTSL SASKISSRKD TKSLSSFSTT TTTTTLKSSS
460 470 480 490 500
SSSSSSSSSS KSNIASSSSS SSNNLTNLLT QSQSISSTST STTTTPTSTS
510 520 530 540 550
PTLASSMSVL SSPTSTTTTS TSTTSTTTTP TKSSCTIITP SIALKLYIND
560 570 580 590 600
LTSAEQSEIL DYPQIYFTGN TNKKTKFNSQ LPNNGYDNDI GEYKVVERDH
610 620 630 640 650
IAYRFEIVSI LGQGSFCQVV KGYDYKTGEM VALKILRNQK RFHNQALTEI
660 670 680 690 700
KILEYLKTND PNSTASIVHL NNYFYFRNHL ILTFELLSMN LYDFLKVNHF
710 720 730 740 750
QGYNLNLVRR FGAQILTSLR FLSKRNIIHA DLKPENILLK SPTKSGIKLI
760 770 780 790 800
DFGSSCFENE QIFTYIQSRF YRSPEVILGT KYDKSIDIWS LGCILVEIFT
810 820 830 840 850
GVPLFPGSDE PEQLACIMEV LGAPPKSVID NSTRKDIFFE DDGTPKPVKN
860 870 880 890 900
STTGELYTIG TKSFKDSIRS GDEDFDNFIL DCLKWEPSQR ITAEQGLKHD
910
WIIKVIAPTA PSTPS
Length:915
Mass (Da):98,276
Last modified:May 24, 2005 - v1
Checksum:iA7BFF787F80278D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000219 Genomic DNA Translation: EAL60552.1
RefSeqiXP_628965.1, XM_628963.1

Genome annotation databases

EnsemblProtistsiEAL60552; EAL60552; DDB_G0293750
GeneIDi8629393
KEGGiddi:DDB_G0293750

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000219 Genomic DNA Translation: EAL60552.1
RefSeqiXP_628965.1, XM_628963.1

3D structure databases

ProteinModelPortaliQ54BC9
SMRiQ54BC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0230102

Proteomic databases

PaxDbiQ54BC9
PRIDEiQ54BC9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL60552; EAL60552; DDB_G0293750
GeneIDi8629393
KEGGiddi:DDB_G0293750

Organism-specific databases

dictyBaseiDDB_G0293750 dyrk2

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
InParanoidiQ54BC9
KOiK18669
OMAiQKKTHRR

Miscellaneous databases

PROiPR:Q54BC9

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDYRK2_DICDI
AccessioniPrimary (citable) accession number: Q54BC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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Main funding by: National Institutes of Health

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