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UniProtKB - Q54BC6 (PSMD2_DICDI)

Entry version 116 (25 May 2022)
Sequence version 1 (24 May 2005)
Previous versions | rss
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Protein

26S proteasome non-ATPase regulatory subunit 2

Gene

psmD2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DDI-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174113, SCF-beta-TrCP mediated degradation of Emi1
R-DDI-174154, APC/C:Cdc20 mediated degradation of Securin
R-DDI-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-187577, SCF(Skp2)-mediated degradation of p27/p21
R-DDI-2467813, Separation of Sister Chromatids
R-DDI-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DDI-4641258, Degradation of DVL
R-DDI-5632684, Hedgehog 'on' state
R-DDI-5658442, Regulation of RAS by GAPs
R-DDI-5687128, MAPK6/MAPK4 signaling
R-DDI-5689603, UCH proteinases
R-DDI-5689880, Ub-specific processing proteases
R-DDI-6798695, Neutrophil degranulation
R-DDI-68949, Orc1 removal from chromatin
R-DDI-69017, CDK-mediated phosphorylation and removal of Cdc6
R-DDI-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-75815, Ubiquitin-dependent degradation of Cyclin D
R-DDI-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751, Regulation of PTEN stability and activity
R-DDI-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:psmD2
ORF Names:DDB_G0293752
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...dictyBasei		DDB_G0293752, psmD2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Proteasome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003274542 – 89326S proteasome non-ATPase regulatory subunit 2Add BLAST892

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q54BC6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		1254399, 1 interactor

STRING: functional protein association networks

More...STRINGi		44689.DDB0232978

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q54BC6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q54BC6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati412 – 445PC 1Add BLAST34
Repeati446 – 482PC 2Add BLAST37
Repeati483 – 517PC 3Add BLAST35
Repeati522 – 555PC 4Add BLAST34
Repeati562 – 583PC 5Add BLAST22
Repeati666 – 700PC 6Add BLAST35
Repeati701 – 735PC 7Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 59DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 59Basic and acidic residuesSequence analysisAdd BLAST45

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the proteasome subunit S2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2005, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008705_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q54BC6

Identification of Orthologs from Complete Genome Data

More...OMAi		KTVYKHM

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q54BC6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016643, 26S_Psome_Rpn1
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002015, Proteasome/cyclosome_rpt
IPR041433, RPN1_C
IPR040892, RPN1_N

The PANTHER Classification System

More...PANTHERi		PTHR10943:SF1, PTHR10943:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01851, PC_rep, 1 hit
PF18051, RPN1_C, 1 hit
PF17781, RPN1_RPN2_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF015965, 26S_Psome_Rpn1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q54BC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQKEVTIPV PAKGGSNKEE DKKDNKDTEE KNTTTNTTTK DNKKDKKKDK 
        60         70         80         90        100
KEETLSPEDE KLKNDLELLV ERSRDEKEEI ALAALEALKT EIRSSTSSMT 
       110        120        130        140        150
SVPKPLKFLR NHYSTLVDIY KNSKEGKAKT SLADILSVLA MANGNDERDT 
       160        170        180        190        200
LKYKLLGSGE AIASWGHEYV KHLATEIGVE YDIKKEENQS VEDLLKLVDE 
       210        220        230        240        250
IVPFQMTHNA EPEACDLLLE VEQLSKIFQY IDENNYSRVC LYLFKCSYYV 
       260        270        280        290        300
PGPDDINILK VCVEIYIKMK QYPDALRVAM KISDPELITE IFKLVENNKS 
       310        320        330        340        350
ILQQLGFLVA RQKIVPDNFN YDSISDIINN SKLSEYFMNL ATDLDIREPK 
       360        370        380        390        400
LPEEIFQSHL DSTSAIADSA RMNLASSFVN AFVNAGFGKD KLMTAEEDTK 
       410        420        430        440        450
WWFKNRELGI LSTVASTGMV VLWDIDGGLT KIDKFLYSQE KHCSNGALMA 
       460        470        480        490        500
IGMLTSGIRS EMDPALSLLA EHINSSNTGT RISAIFGLGL AYAGTQRQDL 
       510        520        530        540        550
MSLLSPCLDD DKEKMEFIGI VGLALGLIFI GSCDPELSTL FVQTLIQRGT 
       560        570        580        590        600
AASESHARFL HLGLGLLYLG KQDAAELALE TLKAIEGKGG EYARLTVEAC 
       610        620        630        640        650
AYAGTGNVLK VQNMLHFCSD GQENPHHGLA VLSIALIAMG EELGSDMCLR 
       660        670        680        690        700
MFDHLLQKGN VHIKRAIPLA LGLLSPSNPR IAIMDILSKL SHDNDPEVAQ 
       710        720        730        740        750
GAILSLGLIG AGTNNARIGG MLRALAVFYG KDVHLFFVRI AQGLLHLGKG 
       760        770        780        790        800
TMTINPYHSD RTLMSPVAVG GLLALLHAGL DIKNILSTQS HYLFFSIVCS 
       810        820        830        840        850
MYPRMLMTLD EDLKPLPVSV RVGQSVDIVG LAGKPKTITG FQTHTTPVLL 
       860        870        880        890 
GYNERAELAT DDYIPLTNIL EGIVILKPNP NASVTSPLAS KKN
Length:893
Mass (Da):98,366
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89C887C081711687
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAFI02000219 Genomic DNA Translation: EAL60553.1

NCBI Reference Sequences

More...RefSeqi		XP_628968.1, XM_628966.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		EAL60553; EAL60553; DDB_G0293752

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8629396

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ddi:DDB_G0293752

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000219 Genomic DNA Translation: EAL60553.1
RefSeqiXP_628968.1, XM_628966.1

3D structure databases

AlphaFoldDBiQ54BC6
SMRiQ54BC6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi1254399, 1 interactor
STRINGi44689.DDB0232978

Proteomic databases

PaxDbiQ54BC6

Genome annotation databases

EnsemblProtistsiEAL60553; EAL60553; DDB_G0293752
GeneIDi8629396
KEGGiddi:DDB_G0293752

Organism-specific databases

dictyBaseiDDB_G0293752, psmD2

Phylogenomic databases

eggNOGiKOG2005, Eukaryota
HOGENOMiCLU_008705_1_0_1
InParanoidiQ54BC6
OMAiKTVYKHM
PhylomeDBiQ54BC6

Enzyme and pathway databases

ReactomeiR-DDI-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174113, SCF-beta-TrCP mediated degradation of Emi1
R-DDI-174154, APC/C:Cdc20 mediated degradation of Securin
R-DDI-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-187577, SCF(Skp2)-mediated degradation of p27/p21
R-DDI-2467813, Separation of Sister Chromatids
R-DDI-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DDI-4641258, Degradation of DVL
R-DDI-5632684, Hedgehog 'on' state
R-DDI-5658442, Regulation of RAS by GAPs
R-DDI-5687128, MAPK6/MAPK4 signaling
R-DDI-5689603, UCH proteinases
R-DDI-5689880, Ub-specific processing proteases
R-DDI-6798695, Neutrophil degranulation
R-DDI-68949, Orc1 removal from chromatin
R-DDI-69017, CDK-mediated phosphorylation and removal of Cdc6
R-DDI-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-75815, Ubiquitin-dependent degradation of Cyclin D
R-DDI-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751, Regulation of PTEN stability and activity
R-DDI-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q54BC6

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR016643, 26S_Psome_Rpn1
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002015, Proteasome/cyclosome_rpt
IPR041433, RPN1_C
IPR040892, RPN1_N
PANTHERiPTHR10943:SF1, PTHR10943:SF1, 1 hit
PfamiView protein in Pfam
PF01851, PC_rep, 1 hit
PF18051, RPN1_C, 1 hit
PF17781, RPN1_RPN2_N, 1 hit
PIRSFiPIRSF015965, 26S_Psome_Rpn1, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSMD2_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54BC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 25, 2022
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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