Apoptosis-associated speck-like protein containing CARD

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• BMP receptor binding Source: Ensembl
• cysteine-type endopeptidase activity Source: InterPro
• interleukin-6 receptor binding Source: Ensembl
• myosin I binding Source: Ensembl
• protease binding Source: Ensembl
• protein homodimerization activity Source: Ensembl
• Pyrin domain binding Source: Ensembl
• tropomyosin binding Source: Ensembl

GO - Biological processⁱ

• activation of innate immune response Source: Ensembl
• cellular response to interleukin-1 Source: Ensembl
• cellular response to lipopolysaccharide Source: Ensembl
• defense response to Gram-negative bacterium Source: Ensembl
• defense response to virus Source: Ensembl
• inflammatory response Source: InterPro
• innate immune response Source: InterPro
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
• myeloid dendritic cell activation Source: Ensembl
• negative regulation of cytokine production involved in inflammatory response Source: Ensembl
• negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
• negative regulation of interferon-beta production Source: Ensembl
• negative regulation of NF-kappaB transcription factor activity Source: Ensembl
• negative regulation of protein serine/threonine kinase activity Source: Ensembl
• positive regulation of adaptive immune response Source: Ensembl
• positive regulation of chemokine production Source: Ensembl
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
• positive regulation of ERK1 and ERK2 cascade Source: Ensembl
• positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
• positive regulation of inflammatory response Source: Ensembl
• positive regulation of interleukin-10 production Source: Ensembl
• positive regulation of interleukin-1 beta production Source: Ensembl
• positive regulation of interleukin-6 production Source: Ensembl
• positive regulation of interleukin-8 production Source: Ensembl
• positive regulation of JNK cascade Source: Ensembl
• positive regulation of NF-kappaB transcription factor activity Source: Ensembl
• positive regulation of release of cytochrome c from mitochondria Source: Ensembl
• positive regulation of T cell activation Source: Ensembl
• positive regulation of tumor necrosis factor production Source: Ensembl
• protein homooligomerization Source: Ensembl
• regulation of intrinsic apoptotic signaling pathway Source: Ensembl
• regulation of tumor necrosis factor-mediated signaling pathway Source: Ensembl
• tumor necrosis factor-mediated signaling pathway Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• BMP receptor binding Source: Ensembl
• interleukin-6 receptor binding Source: Ensembl
• myosin I binding Source: Ensembl
• protease binding Source: Ensembl
• protein homodimerization activity Source: Ensembl
• Pyrin domain binding Source: Ensembl
• tropomyosin binding Source: Ensembl

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGRARDAILD ALENLSGDEL KKFKMKLLTV QLREGYGRIP RGALLQMDAI 
        60         70         80         90        100
DLTDKLVSYY LESYGLELTM TVLRDMGLQE LAEQLQTTKE ESGAVAAAAS 
       110        120        130        140        150
VPAQSTARTG HFVDQHRQAL IARVTEVDGV LDALHGSVLT EGQYQAVRAE 
       160        170        180        190 
TTSQDKMRKL FSFVPSWNLT CKDSLLQALK EIHPYLVMDL EQS        

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ