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UniProtKB - Q54AA2 (Q54AA2_MOUSE)
Protein
Submitted name:
Apoptosis-associated speck-like protein containing CARD
Gene
Pycard
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- BMP receptor binding Source: Ensembl
- cysteine-type endopeptidase activity Source: InterPro
- interleukin-6 receptor binding Source: Ensembl
- myosin I binding Source: Ensembl
- protease binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- Pyrin domain binding Source: Ensembl
- tropomyosin binding Source: Ensembl
GO - Biological processi
- activation of innate immune response Source: Ensembl
- cellular response to interleukin-1 Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- defense response to Gram-negative bacterium Source: Ensembl
- defense response to virus Source: Ensembl
- inflammatory response Source: InterPro
- innate immune response Source: InterPro
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
- myeloid dendritic cell activation Source: Ensembl
- negative regulation of cytokine production involved in inflammatory response Source: Ensembl
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- negative regulation of interferon-beta production Source: Ensembl
- negative regulation of NF-kappaB transcription factor activity Source: Ensembl
- negative regulation of protein serine/threonine kinase activity Source: Ensembl
- positive regulation of adaptive immune response Source: Ensembl
- positive regulation of chemokine production Source: Ensembl
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
- positive regulation of inflammatory response Source: Ensembl
- positive regulation of interleukin-10 production Source: Ensembl
- positive regulation of interleukin-1 beta production Source: Ensembl
- positive regulation of interleukin-6 production Source: Ensembl
- positive regulation of interleukin-8 production Source: Ensembl
- positive regulation of JNK cascade Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: Ensembl
- positive regulation of release of cytochrome c from mitochondria Source: Ensembl
- positive regulation of T cell activation Source: Ensembl
- positive regulation of tumor necrosis factor production Source: Ensembl
- protein homooligomerization Source: Ensembl
- regulation of intrinsic apoptotic signaling pathway Source: Ensembl
- regulation of tumor necrosis factor-mediated signaling pathway Source: Ensembl
- tumor necrosis factor-mediated signaling pathway Source: Ensembl
Keywordsi
Biological process | Inflammatory responseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Apoptosis-associated speck-like protein containing CARDImported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1931465, Pycard |
VEuPathDBi | HostDB:ENSMUSG00000030793 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
- Inflammasome ARBA annotation
Cytosol
- AIM2 inflammasome complex Source: Ensembl
- IkappaB kinase complex Source: Ensembl
- NLRP1 inflammasome complex Source: Ensembl
- NLRP3 inflammasome complex Source: Ensembl
Golgi apparatus
- Golgi membrane Source: Ensembl
Mitochondrion
- mitochondrion Source: Ensembl
Nucleus
- nucleolus Source: Ensembl
- nucleoplasm Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, InflammasomeARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000030793, Expressed in small intestine and 256 other tissues |
Interactioni
GO - Molecular functioni
- BMP receptor binding Source: Ensembl
- interleukin-6 receptor binding Source: Ensembl
- myosin I binding Source: Ensembl
- protease binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- Pyrin domain binding Source: Ensembl
- tropomyosin binding Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 91 | PyrinInterPro annotationAdd BLAST | 91 | |
Domaini | 105 – 193 | CARDInterPro annotationAdd BLAST | 89 |
Phylogenomic databases
HOGENOMi | CLU_113553_1_0_1 |
OMAi | NPAKMRK |
OrthoDBi | 1494108at2759 |
Family and domain databases
CDDi | cd08330, CARD_ASC_NALP1, 1 hit |
Gene3Di | 1.10.533.10, 2 hits |
InterProi | View protein in InterPro IPR001315, CARD IPR033516, CARD8/ASC/NALP1_CARD IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR002398, Pept_C14 |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 2 hits |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS50824, DAPIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54AA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRARDAILD ALENLSGDEL KKFKMKLLTV QLREGYGRIP RGALLQMDAI
60 70 80 90 100
DLTDKLVSYY LESYGLELTM TVLRDMGLQE LAEQLQTTKE ESGAVAAAAS
110 120 130 140 150
VPAQSTARTG HFVDQHRQAL IARVTEVDGV LDALHGSVLT EGQYQAVRAE
160 170 180 190
TTSQDKMRKL FSFVPSWNLT CKDSLLQALK EIHPYLVMDL EQS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB059327 Genomic DNA Translation: BAB97214.1 AK152677 mRNA Translation: BAE31409.1 |
RefSeqi | NP_075747.3, NM_023258.4 |
Genome annotation databases
GeneIDi | 66824 |
KEGGi | mmu:66824 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB059327 Genomic DNA Translation: BAB97214.1 AK152677 mRNA Translation: BAE31409.1 |
RefSeqi | NP_075747.3, NM_023258.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3375, 729 antibodies from 44 providers |
DNASUi | 66824 |
Genome annotation databases
GeneIDi | 66824 |
KEGGi | mmu:66824 |
Organism-specific databases
CTDi | 29108 |
MGIi | MGI:1931465, Pycard |
VEuPathDBi | HostDB:ENSMUSG00000030793 |
Phylogenomic databases
HOGENOMi | CLU_113553_1_0_1 |
OMAi | NPAKMRK |
OrthoDBi | 1494108at2759 |
Miscellaneous databases
BioGRID-ORCSi | 66824, 0 hits in 73 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030793, Expressed in small intestine and 256 other tissues |
Family and domain databases
CDDi | cd08330, CARD_ASC_NALP1, 1 hit |
Gene3Di | 1.10.533.10, 2 hits |
InterProi | View protein in InterPro IPR001315, CARD IPR033516, CARD8/ASC/NALP1_CARD IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR002398, Pept_C14 |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 2 hits |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS50824, DAPIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q54AA2_MOUSE | |
Accessioni | Q54AA2Primary (citable) accession number: Q54AA2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |