UniProtKB - Q549Q4 (Q549Q4_MOUSE)
Protein
T-cell surface antigen CD2
Gene
Cd2
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- signaling receptor binding Source: Ensembl
GO - Biological processi
- heterotypic cell-cell adhesion Source: Ensembl
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of interleukin-8 production Source: Ensembl
- positive regulation of tumor necrosis factor production Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: T-cell surface antigen CD2ARBA annotation |
Gene namesi | Name:Cd2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:88320, Cd2 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- external side of plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 202 – 229 | HelicalSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5014309638 | 23 – 344 | T-cell surface antigen CD2Sequence analysisAdd BLAST | 322 |
Proteomic databases
EPDi | Q549Q4 |
MaxQBi | Q549Q4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027863, Expressed in blood and 90 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 120 | IGvInterPro annotationAdd BLAST | 96 | |
Domaini | 129 – 199 | C2-setInterPro annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 238 – 344 | DisorderedSequence analysisAdd BLAST | 107 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 238 – 253 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 321 – 344 | Pro-richSequence analysisAdd BLAST | 24 |
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_069390_0_0_1 |
OMAi | DIPNFQM |
OrthoDBi | 977841at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR015632, CD2 IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR008424, Ig_C2-set IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF05790, C2-set, 1 hit PF07686, V-set, 1 hit |
PRINTSi | PR01870, CD2ANTIGEN |
SUPFAMi | SSF48726, SSF48726, 2 hits |
i Sequence
Sequence statusi: Complete.
Q549Q4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKCKFLGSFF LLFSLSGKGA DCRDNETIWG VLGHGITLNI PNFQMTDDID
60 70 80 90 100
EVRWVRRGTL VAEFKRKKPP FLISETYEVL ANGSLKIKKP MMRNDSGTYN
110 120 130 140 150
VMVYGTNGMT RLEKDLDVRI LERVSKPMIH WECPNTTLTC AVLQGTDFEL
160 170 180 190 200
KLYQGETLLN SLPQKNMSYQ WTNLNAPFKC EAINPVSKES KMEVVNCPEK
210 220 230 240 250
GLSFYVTVGV GAGGLLLVLL VALFIFCICK RRKRNRRRKD EELEIKASRT
260 270 280 290 300
STVERGPKPH STPAAAAQNS VALQAPPPPG HHLQTPGHRP LPPGHRTREH
310 320 330 340
QQKKRPPPSG TQIHQQKGPP LPRPRVQPKP PCGSGDGVSL PPPN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF065906 mRNA Translation: AAD25886.1 AF065907 mRNA Translation: AAD25887.1 AF065908 mRNA Translation: AAD25888.1 |
RefSeqi | NP_038514.1, NM_013486.2 |
Genome annotation databases
GeneIDi | 12481 |
KEGGi | mmu:12481 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF065906 mRNA Translation: AAD25886.1 AF065907 mRNA Translation: AAD25887.1 AF065908 mRNA Translation: AAD25888.1 |
RefSeqi | NP_038514.1, NM_013486.2 |
3D structure databases
SMRi | Q549Q4 |
ModBasei | Search... |
Proteomic databases
EPDi | Q549Q4 |
MaxQBi | Q549Q4 |
Protocols and materials databases
Antibodypediai | 1086, 2585 antibodies |
Genome annotation databases
GeneIDi | 12481 |
KEGGi | mmu:12481 |
Organism-specific databases
CTDi | 914 |
MGIi | MGI:88320, Cd2 |
Phylogenomic databases
HOGENOMi | CLU_069390_0_0_1 |
OMAi | DIPNFQM |
OrthoDBi | 977841at2759 |
Miscellaneous databases
BioGRID-ORCSi | 12481, 1 hit in 17 CRISPR screens |
ChiTaRSi | Ccnd2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027863, Expressed in blood and 90 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR015632, CD2 IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR008424, Ig_C2-set IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF05790, C2-set, 1 hit PF07686, V-set, 1 hit |
PRINTSi | PR01870, CD2ANTIGEN |
SUPFAMi | SSF48726, SSF48726, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q549Q4_MOUSE | |
Accessioni | Q549Q4Primary (citable) accession number: Q549Q4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |