VPS28

Functionⁱ

Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.UniRule annotation

GO - Biological processⁱ

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transportUniRule annotation, Transport

Biological process

Protein transportUniRule annotation, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vacuolar protein sorting-associated protein 28 homologUniRule annotation
Gene namesⁱ	Name:VPS28Imported ORF Names:hCG_24005Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160948.13

EuPathDBⁱ

HostDB:ENSG00000160948.13

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

EndosomeUniRule annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA38512

PharmGKBⁱ

PA38512

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000160948 Expressed in 227 organ(s), highest expression level in right testis

Bgeeⁱ

ENSG00000160948 Expressed in 227 organ(s), highest expression level in right testis

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q548N1, 18 interactors Q548N1, 18 interactors

IntActⁱ

Q548N1, 18 interactors
Q548N1, 18 interactors

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	13 – 120	VPS28 N-terminalInterPro annotationAdd BLAST		108
Domainⁱ	124 – 220	VPS28 C-terminalInterPro annotationAdd BLAST		97

Sequence similaritiesⁱ

Belongs to the VPS28 family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3284 Eukaryota ENOG4111IQ4 LUCA
HOVERGENⁱ	HBG054248
KEGG Orthology (KO) More...KOⁱ	K12184
OMAⁱ	FKGSKDW

Family and domain databases

Gene3Dⁱ	1.20.120.1130, 1 hit 1.20.1440.200, 1 hit
InterProⁱ	View protein in InterPro IPR037202 ESCRT_assembly_dom IPR007143 Vps28 IPR017899 VPS28_C IPR037206 VPS28_C_sf IPR017898 VPS28_N IPR038358 VPS28_N_sf
PANTHERⁱ	PTHR12937 PTHR12937, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03997 VPS28, 1 hit
PIRSFⁱ	PIRSF017535 VPS28, 1 hit
SUPFAMⁱ	SSF140111 SSF140111, 1 hit SSF140427 SSF140427, 1 hit
PROSITEⁱ	View protein in PROSITE PS51310 VPS28_C, 1 hit PS51313 VPS28_N, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q548N1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFHGIPATPG IGAPGNKPEL YEEVKLYKNA REREKYDNMA ELFAVVKTMQ 
        60         70         80         90        100
ALEKAYIKDC VSPSEYTAAC SRLLVQYKAA FRQVQGSEIS SIDEFCRKFR 
       110        120        130        140        150
LDCPLAMERI KEDRPITIKD DKGNLNRCIA DVVSLFITVM DKLRLEIRAM 
       160        170        180        190        200
DEIQPDLREL METMHRMSHL PPDFEGRQTV SQWLQTLSGM SASDELDDSQ 
       210        220 
VRQMLFDLES AYNAFNRFLH A

Length:221

Mass (Da):25,425

Last modified:May 24, 2005 - v1

Checksum:ⁱB2E1697B82D02AB8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	221	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF316887 mRNA Translation: AAK00314.1 KU178635 mRNA Translation: ALQ34093.1 CH471162 Genomic DNA Translation: EAW82094.1 CH471162 Genomic DNA Translation: EAW82100.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057292.1, NM_016208.3
UniGeneⁱ	Hs.418175 Hs.650693

Genome annotation databases

GeneIDⁱ	51160
KEGGⁱ	hsa:51160

Protein	Similar proteins		Species	Score	Length	Source
Q548N1	Vacuolar protein sorting-associated protein 28 homolog		HUMAN		221	UniRef100_Q9UK41
Vacuolar protein sorting-associated protein 28 homolog		CALJA		221
Vacuolar protein sorting-associated protein 28 homolog		PANTR		221
Vacuolar protein sorting-associated protein 28 homolog		GORGO		221
Vacuolar protein sorting-associated protein 28 homolog		SAIBB		221
+2

Protein	Similar proteins		Species	Score	Length	Source
Q548N1	Vacuolar protein sorting-associated protein 28 homolog		HUMAN		221	UniRef90_Q9UK41
Vacuolar protein sorting-associated protein 28 homolog		BOVIN		221
Vacuolar protein sorting-associated protein 28 homolog		MOUSE		221
Vacuolar protein sorting-associated protein 28 homolog		CALJA		221
Vacuolar protein sorting-associated protein 28 homolog		PANTR		221
+79

Protein	Similar proteins		Species	Score	Length	Source
Q548N1	Vacuolar protein sorting-associated protein 28 homolog		HUMAN		221	UniRef50_Q9UK41
Vacuolar protein sorting-associated protein 28 homolog		MOUSE		221
Vacuolar protein sorting-associated protein 28 homolog		BOVIN		221
Vacuolar protein sorting-associated protein 28 homolog		RAT		228
Vacuolar protein sorting-associated protein 28 homolog		CALJA		221
+263

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF316887 mRNA Translation: AAK00314.1 KU178635 mRNA Translation: ALQ34093.1 CH471162 Genomic DNA Translation: EAW82094.1 CH471162 Genomic DNA Translation: EAW82100.1
RefSeqⁱ	NP_057292.1, NM_016208.3
UniGeneⁱ	Hs.418175 Hs.650693

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q548N1, 18 interactors Q548N1, 18 interactors

IntActⁱ

Q548N1, 18 interactors
Q548N1, 18 interactors

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51160
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	51160
KEGGⁱ	hsa:51160

Organism-specific databases

CTDⁱ	51160
EuPathDBⁱ	HostDB:ENSG00000160948.13
PharmGKBⁱ	PA38512

Phylogenomic databases

eggNOGⁱ	KOG3284 Eukaryota ENOG4111IQ4 LUCA
HOVERGENⁱ	HBG054248
KOⁱ	K12184
OMAⁱ	FKGSKDW

Miscellaneous databases

ChiTaRSⁱ	VPS28 human
GenomeRNAiⁱ	51160

Gene expression databases

Bgeeⁱ	ENSG00000160948 Expressed in 227 organ(s), highest expression level in right testis

Bgeeⁱ

ENSG00000160948 Expressed in 227 organ(s), highest expression level in right testis

Family and domain databases

Gene3Dⁱ	1.20.120.1130, 1 hit 1.20.1440.200, 1 hit
InterProⁱ	View protein in InterPro IPR037202 ESCRT_assembly_dom IPR007143 Vps28 IPR017899 VPS28_C IPR037206 VPS28_C_sf IPR017898 VPS28_N IPR038358 VPS28_N_sf
PANTHERⁱ	PTHR12937 PTHR12937, 1 hit
Pfamⁱ	View protein in Pfam PF03997 VPS28, 1 hit
PIRSFⁱ	PIRSF017535 VPS28, 1 hit
SUPFAMⁱ	SSF140111 SSF140111, 1 hit SSF140427 SSF140427, 1 hit
PROSITEⁱ	View protein in PROSITE PS51310 VPS28_C, 1 hit PS51313 VPS28_N, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q548N1_HUMAN
Accessionⁱ	Q548N1Primary (citable) accession number: Q548N1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 24, 2005
	Last sequence update:	May 24, 2005
	Last modified:	November 7, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q548N1 (Q548N1_HUMAN)

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Vacuolar protein sorting-associated protein 28 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ