The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q548N1 (Q548N1_HUMAN)
Protein
Vacuolar protein sorting-associated protein 28 homolog
Gene
VPS28
Organism
Homo sapiens (Human)
Status
Functioni
Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
UniRule annotationGO - Biological processi
- intracellular transport of virus Source: UniProt
- macroautophagy Source: UniProt
- multivesicular body assembly Source: UniProt
- protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: UniProtKB-UniRule
- viral budding via host ESCRT complex Source: UniProt
Keywordsi
Biological process | Protein transportUniRule annotationARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 28 homologUniRule annotation |
Gene namesi | Name:VPS28Imported ORF Names:hCG_24005Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000160948 |
Subcellular locationi
Endosome
- Endosome membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Endosome
- ESCRT I complex Source: UniProtKB-UniRule
Other locations
- host cell Source: GOC
Keywords - Cellular componenti
EndosomeUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000160948, Expressed in right testis and 241 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 120 | VPS28 N-terminalInterPro annotationAdd BLAST | 108 | |
Domaini | 124 – 220 | VPS28 C-terminalInterPro annotationAdd BLAST | 97 |
Sequence similaritiesi
Belongs to the VPS28 family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_076417_2_0_1 |
OMAi | CDEFPTV |
Family and domain databases
Gene3Di | 1.20.120.1130, 1 hit 1.20.1440.200, 1 hit |
InterProi | View protein in InterPro IPR037202, ESCRT_assembly_dom IPR007143, Vps28 IPR017899, VPS28_C IPR037206, VPS28_C_sf IPR017898, VPS28_N IPR038358, VPS28_N_sf |
PANTHERi | PTHR12937, PTHR12937, 1 hit |
Pfami | View protein in Pfam PF03997, VPS28, 1 hit |
PIRSFi | PIRSF017535, VPS28, 1 hit |
SUPFAMi | SSF140111, SSF140111, 1 hit SSF140427, SSF140427, 1 hit |
PROSITEi | View protein in PROSITE PS51310, VPS28_C, 1 hit PS51313, VPS28_N, 1 hit |
i Sequence
Sequence statusi: Complete.
Q548N1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFHGIPATPG IGAPGNKPEL YEEVKLYKNA REREKYDNMA ELFAVVKTMQ
60 70 80 90 100
ALEKAYIKDC VSPSEYTAAC SRLLVQYKAA FRQVQGSEIS SIDEFCRKFR
110 120 130 140 150
LDCPLAMERI KEDRPITIKD DKGNLNRCIA DVVSLFITVM DKLRLEIRAM
160 170 180 190 200
DEIQPDLREL METMHRMSHL PPDFEGRQTV SQWLQTLSGM SASDELDDSQ
210 220
VRQMLFDLES AYNAFNRFLH A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF316887 mRNA Translation: AAK00314.1 KU178635 mRNA Translation: ALQ34093.1 CH471162 Genomic DNA Translation: EAW82094.1 CH471162 Genomic DNA Translation: EAW82100.1 |
RefSeqi | NP_057292.1, NM_016208.3 |
Genome annotation databases
GeneIDi | 51160 |
KEGGi | hsa:51160 |
MANE-Selecti | ENST00000292510.6; ENSP00000292510.3; NM_016208.4; NP_057292.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF316887 mRNA Translation: AAK00314.1 KU178635 mRNA Translation: ALQ34093.1 CH471162 Genomic DNA Translation: EAW82094.1 CH471162 Genomic DNA Translation: EAW82100.1 |
RefSeqi | NP_057292.1, NM_016208.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q548N1, 18 interactors |
Protocols and materials databases
Antibodypediai | 14872, 201 antibodies from 32 providers |
DNASUi | 51160 |
Genome annotation databases
GeneIDi | 51160 |
KEGGi | hsa:51160 |
MANE-Selecti | ENST00000292510.6; ENSP00000292510.3; NM_016208.4; NP_057292.1 |
Organism-specific databases
CTDi | 51160 |
PharmGKBi | PA38512 |
VEuPathDBi | HostDB:ENSG00000160948 |
Phylogenomic databases
HOGENOMi | CLU_076417_2_0_1 |
OMAi | CDEFPTV |
Miscellaneous databases
BioGRID-ORCSi | 51160, 799 hits in 1087 CRISPR screens |
ChiTaRSi | VPS28, human |
GenomeRNAii | 51160 |
Gene expression databases
Bgeei | ENSG00000160948, Expressed in right testis and 241 other tissues |
Family and domain databases
Gene3Di | 1.20.120.1130, 1 hit 1.20.1440.200, 1 hit |
InterProi | View protein in InterPro IPR037202, ESCRT_assembly_dom IPR007143, Vps28 IPR017899, VPS28_C IPR037206, VPS28_C_sf IPR017898, VPS28_N IPR038358, VPS28_N_sf |
PANTHERi | PTHR12937, PTHR12937, 1 hit |
Pfami | View protein in Pfam PF03997, VPS28, 1 hit |
PIRSFi | PIRSF017535, VPS28, 1 hit |
SUPFAMi | SSF140111, SSF140111, 1 hit SSF140427, SSF140427, 1 hit |
PROSITEi | View protein in PROSITE PS51310, VPS28_C, 1 hit PS51313, VPS28_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q548N1_HUMAN | |
Accessioni | Q548N1Primary (citable) accession number: Q548N1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |