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Entry version 160 (02 Dec 2020)
Sequence version 1 (24 May 2005)
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Protein
Submitted name:

Tlr7 protein

Gene

Tlr7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImportedARBA annotation
Biological processImmunity, Inflammatory responseARBA annotation, Innate immunityARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tlr7 proteinImported
Submitted name:
Toll-like receptor 7Imported
Submitted name:
Toll-like receptor 7 isoformImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tlr7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2176882, Tlr7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei841 – 866HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Endoplasmic reticulumARBA annotation, EndosomeARBA annotation, LysosomeARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q548J0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044583, Expressed in bone marrow macrophage and 125 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q548J0, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q548J0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q548J0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini890 – 1037TIRInterPro annotationAdd BLAST148

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Toll-like receptor family.ARBA annotation

Keywords - Domaini

Leucine-rich repeatARBA annotation, RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006000_2_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPAVSEW

Database of Orthologous Groups

More...
OrthoDBi
303561at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10140, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR041283, LRR_12
IPR032675, LRR_dom_sf
IPR000157, TIR_dom
IPR026880, TLR7
IPR035897, Toll_tir_struct_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR47410:SF2, PTHR47410:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00560, LRR_1, 1 hit
PF18837, LRR_12, 1 hit
PF13855, LRR_8, 4 hits
PF01582, TIR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 12 hits
SM00082, LRRCT, 1 hit
SM00255, TIR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52200, SSF52200, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 19 hits
PS50104, TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q548J0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFSMWTRKR QILIFLNMLL VSRVFGFRWF PKTLPCEVKV NIPEAHVIVD
60 70 80 90 100
CTDKHLTEIP EGIPTNTTNL TLTINHIPSI SPDSFRRLNH LEEIDLRCNC
110 120 130 140 150
VPVLLGSKAN VCTKRLQIRP GSFSGLSDLK ALYLDGNQLL EIPQDLPSSL
160 170 180 190 200
HLLSLEANNI FSITKENLTE LVNIETLYLG QNCYYRNPCN VSYSIEKDAF
210 220 230 240 250
LVMRNLKVLS LKDNNVTAVP TTLPPNLLEL YLYNNIIKKI QENDFNNLNE
260 270 280 290 300
LQVLDLSGNC PRCYNVPYPC TPCENNSPLQ IHDNAFNSLT ELKVLRLHSN
310 320 330 340 350
SLQHVPPTWF KNMRNLQELD LSQNYLAREI EEAKFLHFLP NLVELDFSFN
360 370 380 390 400
YELQVYHASI TLPHSLSSLE NLKILRVKGY VFKELKNSSL SVLHKLPRLE
410 420 430 440 450
VLDLGTNFIK IADLNIFKHF ENLKLIDLSV NKISPSEESR EVGFCPNAQT
460 470 480 490 500
SVDRHGPQVL EALHYFRYDE YARSCRFKNK EPPSFLPLNA DCHIYGQTLD
510 520 530 540 550
LSRNNIFFIK PSDFQHLSFL KCLNLSGNTI GQTLNGSELW PLRELRYLDF
560 570 580 590 600
SNNRLDLLYS TAFEELQSLE VLDLSSNSHY FQAEGITHML NFTKKLRLLD
610 620 630 640 650
KLMMNDNDIS TSASRTMESD SLRILEFRGN HLDVLWRAGD NRYLDFFKNL
660 670 680 690 700
FNLEVLDISR NSLNSLPPEV FEGMPPNLKN LSLAKNGLKS FFWDRLQLLK
710 720 730 740 750
HLEILDLSHN QLTKVPERLA NCSKSLTTLI LKHNQIRQLT KYFLEDALQL
760 770 780 790 800
RYLDISSNKI QVIQKTSFPE NVLNNLEMLV LHHNRFLCNC DAVWFVWWVN
810 820 830 840 850
HTDVTIPYLA TDVTCVGPGA HKGQSVISLD LYTCELDLTN LILFSVSISS
860 870 880 890 900
VLFLMVVMTT SHLFFWDMWY IYYFWKAKIK GYQHLQSMES CYDAFIVYDT
910 920 930 940 950
KNSAVTEWVL QELVAKLEDP REKHFNLCLE ERDWLPGQPV LENLSQSIQL
960 970 980 990 1000
SKKTVFVMTQ KYAKTESFKM AFYLSHQRLL DEKVDVIILI FLEKPLQKSK
1010 1020 1030 1040 1050
FLQLRKRLCR SSVLEWPANP QAHPYFWQCL KNALTTDNHV AYSQMFKETV
Length:1,050
Mass (Da):121,837
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i495B75DEE849D8EE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC120596 mRNA Translation: AAI20597.1
BC132385 mRNA Translation: AAI32386.1
AF334942 mRNA Translation: AAL73191.1
AF334943 mRNA Translation: AAL73192.1
AK036549 mRNA Translation: BAC29472.1
AK154906 mRNA Translation: BAE32916.1
AK156908 mRNA Translation: BAE33892.1

NCBI Reference Sequences

More...
RefSeqi
NP_001277684.1, NM_001290755.1
NP_001277685.1, NM_001290756.1
NP_001277686.1, NM_001290757.1
NP_001277687.1, NM_001290758.1
NP_573474.1, NM_133211.4
XP_011246087.1, XM_011247785.1
XP_011246088.1, XM_011247786.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
170743

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:170743

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120596 mRNA Translation: AAI20597.1
BC132385 mRNA Translation: AAI32386.1
AF334942 mRNA Translation: AAL73191.1
AF334943 mRNA Translation: AAL73192.1
AK036549 mRNA Translation: BAC29472.1
AK154906 mRNA Translation: BAE32916.1
AK156908 mRNA Translation: BAE33892.1
RefSeqiNP_001277684.1, NM_001290755.1
NP_001277685.1, NM_001290756.1
NP_001277686.1, NM_001290757.1
NP_001277687.1, NM_001290758.1
NP_573474.1, NM_133211.4
XP_011246087.1, XM_011247785.1
XP_011246088.1, XM_011247786.1

3D structure databases

SMRiQ548J0
ModBaseiSearch...

Chemistry databases

BindingDBiQ548J0

Proteomic databases

MaxQBiQ548J0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
8500, 977 antibodies

Genome annotation databases

GeneIDi170743
KEGGimmu:170743

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51284
MGIiMGI:2176882, Tlr7

Phylogenomic databases

HOGENOMiCLU_006000_2_0_1
OMAiDPAVSEW
OrthoDBi303561at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
170743, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tlr7, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000044583, Expressed in bone marrow macrophage and 125 other tissues
ExpressionAtlasiQ548J0, baseline and differential

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR041283, LRR_12
IPR032675, LRR_dom_sf
IPR000157, TIR_dom
IPR026880, TLR7
IPR035897, Toll_tir_struct_dom_sf
PANTHERiPTHR47410:SF2, PTHR47410:SF2, 1 hit
PfamiView protein in Pfam
PF00560, LRR_1, 1 hit
PF18837, LRR_12, 1 hit
PF13855, LRR_8, 4 hits
PF01582, TIR, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 12 hits
SM00082, LRRCT, 1 hit
SM00255, TIR, 1 hit
SUPFAMiSSF52200, SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 19 hits
PS50104, TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ548J0_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q548J0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: December 2, 2020
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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