UniProtKB - Q547U9 (Q547U9_HUMAN)
Protein
Glutamate receptor
Gene
NR2A
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.UniRule annotation
GO - Molecular functioni
- calcium channel activity Source: Ensembl
- NMDA glutamate receptor activity Source: Ensembl
GO - Biological processi
- directional locomotion Source: Ensembl
- dopamine metabolic process Source: Ensembl
- excitatory postsynaptic potential Source: Ensembl
- long-term synaptic potentiation Source: Ensembl
- memory Source: Ensembl
- negative regulation of protein catabolic process Source: Ensembl
- neurogenesis Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- protein localization to postsynaptic membrane Source: Ensembl
- response to amphetamine Source: Ensembl
- response to drug Source: Ensembl
- response to ethanol Source: Ensembl
- response to wounding Source: Ensembl
- sensory perception of pain Source: Ensembl
- serotonin metabolic process Source: Ensembl
- sleep Source: Ensembl
- startle response Source: Ensembl
- visual learning Source: Ensembl
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channelUniRule annotationARBA annotation, ReceptorUniRule annotationImportedARBA annotation |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate receptorUniRule annotation |
Gene namesi | Name:NR2AImported Synonyms:GRIN2AImported ORF Names:hCG_14641Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000183454.14 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Plasma Membrane
- integral component of postsynaptic density membrane Source: Ensembl
- NMDA selective glutamate receptor complex Source: Ensembl
- presynaptic membrane Source: Ensembl
Other locations
- cell surface Source: Ensembl
- glutamatergic synapse Source: Ensembl
- neuron projection Source: Ensembl
- synaptic vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 557 – 579 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 629 – 651 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 820 – 843 | HelicalUniRule annotationAdd BLAST | 24 |
Keywords - Cellular componenti
Cell junction, Cell membraneUniRule annotationARBA annotation, Membrane, Postsynaptic cell membraneUniRule annotationARBA annotation, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | UniRule annotationAdd BLAST | 27 | |
ChainiPRO_5014309654 | 28 – 1464 | Glutamate receptorUniRule annotationAdd BLAST | 1437 |
Keywords - PTMi
GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000183454, Expressed in primary visual cortex and 157 other tissues |
ExpressionAtlasi | Q547U9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 431 – 798 | PBPeInterPro annotationAdd BLAST | 368 | |
Domaini | 439 – 502 | Lig_chan-Glu_bdInterPro annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 997 – 1083 | DisorderedSequence analysisAdd BLAST | 87 | |
Regioni | 1335 – 1372 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1019 – 1036 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1037 – 1083 | PolyampholyteSequence analysisAdd BLAST | 47 | |
Compositional biasi | 1353 – 1372 | PolyampholyteSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]UniRule annotation
Keywords - Domaini
SignalUniRule annotationARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
OMAi | PKYPRDC |
OrthoDBi | 188544at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR018884, NMDAR2_C IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit PF10565, NMDAR2_C, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
i Sequence
Sequence statusi: Complete.
Q547U9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRVGYWTLL VLPALLVWRG PAPSAAAEKG PPALNIAVML GHSHDVTERE
60 70 80 90 100
LRTLWGPEQA AGLPLDVNVV ALLMNRTDPK SLITHVCDLM SGARIHGLVF
110 120 130 140 150
GDDTDQEAVA QMLDFISSHT FVPILGIHGG ASMIMADKDP TSTFFQFGAS
160 170 180 190 200
IQQQATVMLK IMQDYDWHVF SLVTTIFPGY REFISFVKTT VDNSFVGWDM
210 220 230 240 250
QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL SEARSLGLTG
260 270 280 290 300
YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYSLEA RVRDGIGILT
310 320 330 340 350
TAASSMLEKF SYIPEAKASC YGQMERPEVP MHTLHPFMVN VTWDGKDLSF
360 370 380 390 400
TEEGYQVHPR LVVIVLNKDR EWEKVGKWEN HTLSLRHAVW PRYKSFSDCE
410 420 430 440 450
PDDNHLSIVT LEEAPFVIVE DIDPLTETCV RNTVPCRKFV KINNSTNEGM
460 470 480 490 500
NVKKCCKGFC IDILKKLSRT VKFTYDLYLV TNGKHGKKVN NVWNGMIGEV
510 520 530 540 550
VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS NGTVSPSAFL
560 570 580 590 600
EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT
610 620 630 640 650
IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA
660 670 680 690 700
AFMIQEEFVD QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY
710 720 730 740 750
MHQYMTKFNQ KGVEDALVSL KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI
760 770 780 790 800
GSGYIFATTG YGIALQKGSP WKRQIDLALL QFVGDGEMEE LETLWLTGIC
810 820 830 840 850
HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL FYWKLRFCFT
860 870 880 890 900
GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS
910 920 930 940 950
AKNISSMSNM NSSRMDSPKR AADFIQRGSL IMDMVSDKGN LMYSDNRSFQ
960 970 980 990 1000
GKESIFGDNM NELQTFVANR QKDNLNNYVF QGQHPLTLNE SNPNTVEVAV
1010 1020 1030 1040 1050
STESKANSRP RQLWKKSVDS IRQDSLSQNP VSQRDEATAE NRTHSLKSPR
1060 1070 1080 1090 1100
YLPEEMAHSD ISETSNRATC HREPDNSKNH KTKDNFKRSV ASKYPKDCSE
1110 1120 1130 1140 1150
VERTYLKTKS SSPRDKIYTI DGEKEPGFHL DPPQFVENVT LPENVDFPDP
1160 1170 1180 1190 1200
YQDPSENFRK GDSTLPMNRN PLHNEEGLSN NDQYKLYSKH FTLKDKGSPH
1210 1220 1230 1240 1250
SETSERYRQN STHCRSCLSN MPTYSGHFTM RSPFKCDACL RMGNLYDIDE
1260 1270 1280 1290 1300
DQMLQETGNP ATGEQVYQQD WAQNNALQLQ KNKLRISRQH SYDNIVDKPR
1310 1320 1330 1340 1350
ELDLSRPSRS ISLKDRERLL EGNFYGSLFS VPSSKLSGKK SSLFPQGLED
1360 1370 1380 1390 1400
SKRSKSLLPD HTSDNPFLHS HRDDQRLVIG RCPSDPYKHS LPSQAVNDSY
1410 1420 1430 1440 1450
LRSSLRSTAS YCSRDSRGHN DVYISEHVMP YAANKNNMYS TPRVLNSCSN
1460
RRVYKKMPSI ESDV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AH012185 , AF443857, AF443858, AF443859, AF443860, AF443861, AF443862, AF443863, AF443864, AF443865, AF443867 Genomic DNA Translation: AAN75825.1 CH471112 Genomic DNA Translation: EAW85187.1 |
RefSeqi | NP_000824.1, NM_000833.4 NP_001127879.1, NM_001134407.2 |
Genome annotation databases
GeneIDi | 2903 |
KEGGi | hsa:2903 |
UCSCi | uc002czo.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AH012185 , AF443857, AF443858, AF443859, AF443860, AF443861, AF443862, AF443863, AF443864, AF443865, AF443867 Genomic DNA Translation: AAN75825.1 CH471112 Genomic DNA Translation: EAW85187.1 |
RefSeqi | NP_000824.1, NM_000833.4 NP_001127879.1, NM_001134407.2 |
3D structure databases
SMRi | Q547U9 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q547U9 |
Protocols and materials databases
Antibodypediai | 1402, 758 antibodies |
DNASUi | 2903 |
Genome annotation databases
GeneIDi | 2903 |
KEGGi | hsa:2903 |
UCSCi | uc002czo.5, human |
Organism-specific databases
CTDi | 2903 |
PharmGKBi | PA28979 |
VEuPathDBi | HostDB:ENSG00000183454.14 |
Phylogenomic databases
OMAi | PKYPRDC |
OrthoDBi | 188544at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2903, 3 hits in 988 CRISPR screens |
ChiTaRSi | GRIN2A, human |
GenomeRNAii | 2903 |
Gene expression databases
Bgeei | ENSG00000183454, Expressed in primary visual cortex and 157 other tissues |
ExpressionAtlasi | Q547U9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR018884, NMDAR2_C IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit PF10565, NMDAR2_C, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q547U9_HUMAN | |
Accessioni | Q547U9Primary (citable) accession number: Q547U9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |