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Entry version 130 (07 Oct 2020)
Sequence version 2 (26 Sep 2001)
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Protein

Glucan 1,6-alpha-glucosidase

Gene

dexB

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The physiological substrates may be short isomaltosaccharides.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides. EC:3.2.1.70

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei194NucleophileBy similarity1
Active sitei236Proton donorBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei313Transition state stabilizerBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SPNE170187:G1FZB-351-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH13, Glycoside Hydrolase Family 13

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucan 1,6-alpha-glucosidase (EC:3.2.1.70)
Alternative name(s):
Dextran glucosidase
Exo-1,6-alpha-glucosidase
Glucodextranase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dexB
Ordered Locus Names:SP_0342
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri170187 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000585 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000543401 – 535Glucan 1,6-alpha-glucosidaseAdd BLAST535

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q54796

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
170187.SP_0342

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54796

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0366, Bacteria

KEGG Orthology (KO)

More...
KOi
K01215

Identification of Orthologs from Complete Genome Data

More...
OMAi
RDWYWWR

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006047, Glyco_hydro_13_cat_dom
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR032091, Malt_amylase_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00128, Alpha-amylase, 1 hit
PF16657, Malt_amylase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00642, Aamy, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445, SSF51445, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54796-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEKWWHNAV VYQVYPKSFM DSNGDGVGDL PGITSKLDYL AKLGITAIWL
60 70 80 90 100
SPVYDSPMDD NGYDIADYQA IAAIFGTMED MDQLIAEAKK RDIRIIMDLV
110 120 130 140 150
VNHTSDEHAW FVEACENTDS PERDYYIWRD EPNDLDSIFS GSAWEYDEKS
160 170 180 190 200
GQYYLHFFSK KQPDLNWENE KLRQKIYEMM NFWIDKGIGG FRMDVIDMIG
210 220 230 240 250
KIPDEKVVNN GPMLHPYLKE MNQATFGDKD LLTVGETWGA TPEIAKFYSD
260 270 280 290 300
PKGQELSMVF QFEHIGLQYQ EGQPKWHYQK ELNIAKLKEI FNKWQTELGV
310 320 330 340 350
EDGWNSLFWN NHDLPRIVSI WGNDQEYREK SAKAFAILLH LMRGTPYIYQ
360 370 380 390 400
GEEIGMTNYP FETLDQVEDI ESLNYAREAL EKGVPIEEIM DSIRVIGRDN
410 420 430 440 450
ARTPMQWDES KNAGFSTGQP WLAVNPNYEM INVQEALANP DSIFYTYQKL
460 470 480 490 500
VQIRKENSWL VRADFELLDT ADKVFAYIRK DGDRRFLVVA NLSNEEQDLT
510 520 530
VEGKVKSVLI ENTAAKEVLE KQVLAPWDAF CVELL
Length:535
Mass (Da):62,035
Last modified:September 26, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD78F733204DA944
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti375 – 381YAREALE → MRVRLLK in AAA21853 (PubMed:8021229).Curated7
Sequence conflicti376A → P in CAA87400 (PubMed:8566758).Curated1
Sequence conflicti418G → D in AAC38725 (PubMed:9466257).Curated1
Sequence conflicti418G → D in AAC38739 (PubMed:9466257).Curated1
Sequence conflicti514 – 519AAKEVL → LAQEVF in CAA87400 (PubMed:8566758).Curated6
Sequence conflicti514 – 519AAKEVL → LAQEVF in CAB05933 (PubMed:11902728).Curated6
Sequence conflicti514 – 519AAKEVL → LAQEVF in AAA21853 (PubMed:8021229).Curated6
Sequence conflicti514 – 519AAKEVL → LAQEVF in AAC38714 (PubMed:9466257).Curated6
Sequence conflicti514 – 519AAKEVL → LAQEVF in AAC38720 (PubMed:9466257).Curated6
Sequence conflicti514 – 519AAKEVL → LAQEVF in AAC38725 (PubMed:9466257).Curated6
Sequence conflicti514 – 519AAKEVL → LAQEVF in AAC38729 (PubMed:9466257).Curated6
Sequence conflicti514 – 519AAKEVL → LAQEVF in AAC38734 (PubMed:9466257).Curated6
Sequence conflicti514 – 519AAKEVL → LAQEVF in AAC38739 (PubMed:9466257).Curated6
Sequence conflicti514 – 519AAKEVL → LAQEVF in AAC38763 (PubMed:9466257).Curated6
Sequence conflicti523 – 525VLA → ILV in CAA87400 (PubMed:8566758).Curated3
Sequence conflicti523 – 525VLA → ILV in CAB05933 (PubMed:11902728).Curated3
Sequence conflicti523 – 525VLA → ILV in AAA21853 (PubMed:8021229).Curated3
Sequence conflicti523 – 525VLA → ILV in AAC38714 (PubMed:9466257).Curated3
Sequence conflicti523 – 525VLA → ILV in AAC38720 (PubMed:9466257).Curated3
Sequence conflicti523 – 525VLA → ILV in AAC38725 (PubMed:9466257).Curated3
Sequence conflicti523 – 525VLA → ILV in AAC38729 (PubMed:9466257).Curated3
Sequence conflicti523 – 525VLA → ILV in AAC38734 (PubMed:9466257).Curated3
Sequence conflicti523 – 525VLA → ILV in AAC38739 (PubMed:9466257).Curated3
Sequence conflicti523 – 525VLA → ILV in AAC38763 (PubMed:9466257).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti461V → I in strain: 406 / Type 3, 19F and SP-VA96. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE005672 Genomic DNA Translation: AAK74516.1
Z47210 Genomic DNA Translation: CAA87400.1
Z83335 Genomic DNA Translation: CAB05933.1
U04047 Genomic DNA Translation: AAA21853.1
AF030367 Genomic DNA Translation: AAC38714.1
AF030368 Genomic DNA Translation: AAC38720.1
AF030369 Genomic DNA Translation: AAC38725.1
AF030370 Genomic DNA Translation: AAC38729.1
AF030371 Genomic DNA Translation: AAC38734.1
AF030372 Genomic DNA Translation: AAC38739.1
AF030374 Genomic DNA Translation: AAC38763.1
X85787 Genomic DNA Translation: CAA59784.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C95040
T50029

NCBI Reference Sequences

More...
RefSeqi
WP_001156825.1, NZ_AKVY01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAK74516; AAK74516; SP_0342

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spn:SP_0342

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA Translation: AAK74516.1
Z47210 Genomic DNA Translation: CAA87400.1
Z83335 Genomic DNA Translation: CAB05933.1
U04047 Genomic DNA Translation: AAA21853.1
AF030367 Genomic DNA Translation: AAC38714.1
AF030368 Genomic DNA Translation: AAC38720.1
AF030369 Genomic DNA Translation: AAC38725.1
AF030370 Genomic DNA Translation: AAC38729.1
AF030371 Genomic DNA Translation: AAC38734.1
AF030372 Genomic DNA Translation: AAC38739.1
AF030374 Genomic DNA Translation: AAC38763.1
X85787 Genomic DNA Translation: CAA59784.1
PIRiC95040
T50029
RefSeqiWP_001156825.1, NZ_AKVY01000001.1

3D structure databases

SMRiQ54796
ModBaseiSearch...

Protein-protein interaction databases

STRINGi170187.SP_0342

Protein family/group databases

CAZyiGH13, Glycoside Hydrolase Family 13

Proteomic databases

PRIDEiQ54796

Genome annotation databases

EnsemblBacteriaiAAK74516; AAK74516; SP_0342
KEGGispn:SP_0342

Phylogenomic databases

eggNOGiCOG0366, Bacteria
KOiK01215
OMAiRDWYWWR

Enzyme and pathway databases

BioCyciSPNE170187:G1FZB-351-MONOMER

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR006047, Glyco_hydro_13_cat_dom
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR032091, Malt_amylase_C
PfamiView protein in Pfam
PF00128, Alpha-amylase, 1 hit
PF16657, Malt_amylase_C, 1 hit
SMARTiView protein in SMART
SM00642, Aamy, 1 hit
SUPFAMiSSF51445, SSF51445, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEXB_STRPN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54796
Secondary accession number(s): O07337
, O54522, P96472, Q54514
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 26, 2001
Last modified: October 7, 2020
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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