UniProtKB - Q545V4 (Q545V4_MOUSE)
Protein
Submitted name:
Oxytocin
Gene
Oxt
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- neurohypophyseal hormone activity Source: InterPro
- oxytocin receptor binding Source: Ensembl
GO - Biological processi
- drinking behavior Source: Ensembl
- eating behavior Source: Ensembl
- female pregnancy Source: Ensembl
- grooming behavior Source: Ensembl
- heart development Source: Ensembl
- hyperosmotic salinity response Source: Ensembl
- male mating behavior Source: Ensembl
- maternal aggressive behavior Source: Ensembl
- maternal behavior Source: Ensembl
- memory Source: Ensembl
- negative regulation of blood pressure Source: Ensembl
- negative regulation of gastric acid secretion Source: Ensembl
- negative regulation of urine volume Source: Ensembl
- positive regulation of blood pressure Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of female receptivity Source: Ensembl
- positive regulation of hindgut contraction Source: Ensembl
- positive regulation of norepinephrine secretion Source: Ensembl
- positive regulation of ossification Source: Ensembl
- positive regulation of penile erection Source: Ensembl
- positive regulation of prostaglandin secretion Source: Ensembl
- positive regulation of renal sodium excretion Source: Ensembl
- positive regulation of synapse assembly Source: Ensembl
- positive regulation of synaptic transmission Source: Ensembl
- positive regulation of uterine smooth muscle contraction Source: Ensembl
- regulation of heart rate Source: Ensembl
- regulation of sensory perception of pain Source: Ensembl
- response to activity Source: Ensembl
- response to amphetamine Source: Ensembl
- response to cAMP Source: Ensembl
- response to cocaine Source: Ensembl
- response to electrical stimulus Source: Ensembl
- response to estradiol Source: Ensembl
- response to ether Source: Ensembl
- response to external biotic stimulus Source: AgBase
- response to food Source: AgBase
- response to glucocorticoid Source: Ensembl
- response to mechanical stimulus Source: AgBase
- response to peptide hormone Source: Ensembl
- response to progesterone Source: Ensembl
- response to prostaglandin E Source: Ensembl
- response to retinoic acid Source: Ensembl
- response to sucrose Source: Ensembl
- sleep Source: Ensembl
- social behavior Source: Ensembl
- sperm ejaculation Source: Ensembl
Keywordsi
Molecular function | HormoneARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: OxytocinImported |
Gene namesi | Name:OxtImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97453, Oxt |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: AgBase
Other locations
- secretory granule Source: Ensembl
- terminal bouton Source: Ensembl
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5014309645 | 20 – 125 | Sequence analysisAdd BLAST | 106 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 20 ↔ 25 | UniRule annotation | ||
Disulfide bondi | 41 ↔ 85 | UniRule annotation | ||
Disulfide bondi | 44 ↔ 58 | UniRule annotation | ||
Disulfide bondi | 52 ↔ 75 | UniRule annotation | ||
Disulfide bondi | 59 ↔ 65 | UniRule annotation | ||
Disulfide bondi | 92 ↔ 104 | UniRule annotation | ||
Disulfide bondi | 98 ↔ 116 | UniRule annotation | ||
Disulfide bondi | 105 ↔ 110 | UniRule annotation |
Keywords - PTMi
AmidationARBA annotation, Cleavage on pair of basic residuesARBA annotation, Disulfide bondUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000027301, Expressed in supraoptic nucleus and 82 other tissues |
ExpressionAtlasi | Q545V4, baseline and differential |
Interactioni
GO - Molecular functioni
- neurohypophyseal hormone activity Source: InterPro
- oxytocin receptor binding Source: Ensembl
Family & Domainsi
Sequence similaritiesi
Belongs to the vasopressin/oxytocin family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_125770_1_0_1 |
OMAi | DMRKCLP |
OrthoDBi | 1548839at2759 |
Family and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit |
PIRSFi | PIRSF001815, Nonapeptide_hormone_precursor, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q545V4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG
60 70 80 90 100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA
110 120
TGICCSPDGC RTDPACDPES AFSER
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC117030 mRNA Translation: AAI17031.1 BC117032 mRNA Translation: AAI17033.1 AK003042 mRNA Translation: BAB22527.1 |
RefSeqi | NP_035155.1, NM_011025.4 |
Genome annotation databases
GeneIDi | 18429 |
KEGGi | mmu:18429 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC117030 mRNA Translation: AAI17031.1 BC117032 mRNA Translation: AAI17033.1 AK003042 mRNA Translation: BAB22527.1 |
RefSeqi | NP_035155.1, NM_011025.4 |
3D structure databases
SMRi | Q545V4 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 7257, 241 antibodies |
Genome annotation databases
GeneIDi | 18429 |
KEGGi | mmu:18429 |
Organism-specific databases
CTDi | 5020 |
MGIi | MGI:97453, Oxt |
Phylogenomic databases
HOGENOMi | CLU_125770_1_0_1 |
OMAi | DMRKCLP |
OrthoDBi | 1548839at2759 |
Miscellaneous databases
BioGRID-ORCSi | 18429, 0 hits in 17 CRISPR screens |
ChiTaRSi | Oxt, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027301, Expressed in supraoptic nucleus and 82 other tissues |
ExpressionAtlasi | Q545V4, baseline and differential |
Family and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit |
PIRSFi | PIRSF001815, Nonapeptide_hormone_precursor, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q545V4_MOUSE | |
Accessioni | Q545V4Primary (citable) accession number: Q545V4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |