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UniProtKB - Q544S4 (Q544S4_MOUSE)

Entry version 129 (10 Feb 2021)
Sequence version 1 (24 May 2005)
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Protein
Submitted name:

CLAST6

Gene

Laptm5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CLAST6Imported
Submitted name:
Lysosomal-associated protein transmembrane 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Laptm5Imported
Synonyms:Clast6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:108046, Laptm5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 41HelicalSequence analysisAdd BLAST22
Transmembranei62 – 85HelicalSequence analysisAdd BLAST24
Transmembranei91 – 115HelicalSequence analysisAdd BLAST25
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000028581, Expressed in stroma of bone marrow and 291 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q544S4, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q544S4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni242 – 261DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1065422_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		AIRQTCC

Database of Orthologous Groups

More...OrthoDBi		1584977at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004687, LAPTM4/5
IPR018396, LAPTM_4A/5
IPR018397, Lysosomal-assoc_TM_prot5

The PANTHER Classification System

More...PANTHERi		PTHR12479:SF2, PTHR12479:SF2, 3 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03821, Mtp, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00799, mtp, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q544S4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRAAPVRQ TCCCFNIRVA TIALAIYHIV MSVLLFIEHV VEVARGKVSC 
        60         70         80         90        100
RFFKMPYLRM ADLLSSFLLI GVLFIISISL LFGVVKNREK YLIPFLSLQI 
       110        120        130        140        150
MDFLLCLLTL LGSYIELPAY LKLARPRPGP SKVPLMTLQL LDFCLSILTL 
       160        170        180        190        200
CSSYMEVPTY LNFKSMNHMN YLPSQEGVPH SQFINMMLIF SVAFITVLIL 
       210        220        230        240        250
KVYMFKCVYT CYKFLKHMNS AMEDSSSKMF LKVALPSYEE ALSLPPKTPE 
       260 
GDPAPPPYSE V
Length:261
Mass (Da):29,602
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70B3FA0AFE6743D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC158032 mRNA Translation: AAI58033.1
AF364050 mRNA Translation: AAK50858.1
AK031802 mRNA Translation: BAC27556.1
AK050633 mRNA Translation: BAC34354.1
AK089508 mRNA Translation: BAC40908.1
AK153877 mRNA Translation: BAE32226.1
AK155744 mRNA Translation: BAE33412.1
AK163146 mRNA Translation: BAE37213.1
AK171053 mRNA Translation: BAE42214.1
AK171057 mRNA Translation: BAE42216.1
AK171149 mRNA Translation: BAE42276.1
AK171172 mRNA Translation: BAE42292.1
AK171213 mRNA Translation: BAE42317.1
AK171236 mRNA Translation: BAE42332.1
AK171244 mRNA Translation: BAE42337.1
AK171250 mRNA Translation: BAE42342.1
AK171269 mRNA Translation: BAE42355.1
AK171270 mRNA Translation: BAE42356.1
AK171285 mRNA Translation: BAE42368.1
AK171481 mRNA Translation: BAE42482.1
AK171562 mRNA Translation: BAE42527.1
AK171571 mRNA Translation: BAE42532.1
AK171575 mRNA Translation: BAE42535.1
AK172486 mRNA Translation: BAE43030.1
AK172707 mRNA Translation: BAE43139.1

NCBI Reference Sequences

More...RefSeqi		NP_034816.1, NM_010686.3
XP_017175490.1, XM_017320001.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		16792

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:16792

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC158032 mRNA Translation: AAI58033.1
AF364050 mRNA Translation: AAK50858.1
AK031802 mRNA Translation: BAC27556.1
AK050633 mRNA Translation: BAC34354.1
AK089508 mRNA Translation: BAC40908.1
AK153877 mRNA Translation: BAE32226.1
AK155744 mRNA Translation: BAE33412.1
AK163146 mRNA Translation: BAE37213.1
AK171053 mRNA Translation: BAE42214.1
AK171057 mRNA Translation: BAE42216.1
AK171149 mRNA Translation: BAE42276.1
AK171172 mRNA Translation: BAE42292.1
AK171213 mRNA Translation: BAE42317.1
AK171236 mRNA Translation: BAE42332.1
AK171244 mRNA Translation: BAE42337.1
AK171250 mRNA Translation: BAE42342.1
AK171269 mRNA Translation: BAE42355.1
AK171270 mRNA Translation: BAE42356.1
AK171285 mRNA Translation: BAE42368.1
AK171481 mRNA Translation: BAE42482.1
AK171562 mRNA Translation: BAE42527.1
AK171571 mRNA Translation: BAE42532.1
AK171575 mRNA Translation: BAE42535.1
AK172486 mRNA Translation: BAE43030.1
AK172707 mRNA Translation: BAE43139.1
RefSeqiNP_034816.1, NM_010686.3
XP_017175490.1, XM_017320001.1

3D structure databases

SMRiQ544S4
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		54047, 91 antibodies

Genome annotation databases

GeneIDi16792
KEGGimmu:16792

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7805
MGIiMGI:108046, Laptm5

Phylogenomic databases

HOGENOMiCLU_1065422_0_0_1
OMAiAIRQTCC
OrthoDBi1584977at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		16792, 0 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Laptm5, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000028581, Expressed in stroma of bone marrow and 291 other tissues
ExpressionAtlasiQ544S4, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR004687, LAPTM4/5
IPR018396, LAPTM_4A/5
IPR018397, Lysosomal-assoc_TM_prot5
PANTHERiPTHR12479:SF2, PTHR12479:SF2, 3 hits
PfamiView protein in Pfam
PF03821, Mtp, 1 hit
TIGRFAMsiTIGR00799, mtp, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ544S4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q544S4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: February 10, 2021
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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