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Protein
Submitted name:

Interleukin 2 receptor, alpha chain

Gene

Il2ra

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 2 receptor, alpha chainImported
Submitted name:
Interleukin 2 receptor, alpha chain, isoform CRA_bImported
Submitted name:
Interleukin-2 receptor alpha subunitImported
Gene namesi
Name:Il2raImported
ORF Names:mCG_9569Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96549 Il2ra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501430962222 – 268Sequence analysisAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi121 ↔ 164PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000026770 Expressed in 32 organ(s), highest expression level in bone marrow

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 79SushiInterPro annotationAdd BLAST58
Domaini119 – 182SushiInterPro annotationAdd BLAST64

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410J24B Eukaryota
ENOG41116U7 LUCA
HOVERGENiHBG052109
KOiK05068
OMAiHYQCIQG
OrthoDBiEOG091G0NHH

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR015486 IL-2_rcpt_alpha
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10573 PTHR10573, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits

Sequencei

Sequence statusi: Complete.

Q544I2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPRLLMLGF LSLTIVPSCR AELCLYDPPE VPNATFKALS YKNGTILNCE
60 70 80 90 100
CKRGFRRLKE LVYMRCLGNS WSSNCQCTSN SHDKSRKQVT AQLEHQKEQQ
110 120 130 140 150
TTTDMQKPTQ SMHQENLTGH CREPPPWKHE DSKRIYHFVE GQSVHYECIP
160 170 180 190 200
GYKALQRGPA ISICKMKCGK TGWTQPQLTC VDEREHHRFL ASEESQGSRN
210 220 230 240 250
SSPESETSCP ITTTDFPQPT ETTAMTETFV LTMEYKVAVA SCLFLLISIL
260
LLSGLTWQHR WRKSRRTI
Length:268
Mass (Da):30,723
Last modified:May 24, 2005 - v1
Checksum:i20C8F712B719192D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114437 mRNA Translation: AAI14438.1
DQ677837 Genomic DNA Translation: ABM01861.1
DQ677838 Genomic DNA Translation: ABM01862.1
AK037369 mRNA Translation: BAC29797.1
CH466542 Genomic DNA Translation: EDL08019.1
RefSeqiNP_032393.3, NM_008367.3
UniGeneiMm.915

Genome annotation databases

GeneIDi16184
KEGGimmu:16184

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114437 mRNA Translation: AAI14438.1
DQ677837 Genomic DNA Translation: ABM01861.1
DQ677838 Genomic DNA Translation: ABM01862.1
AK037369 mRNA Translation: BAC29797.1
CH466542 Genomic DNA Translation: EDL08019.1
RefSeqiNP_032393.3, NM_008367.3
UniGeneiMm.915

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16184
KEGGimmu:16184

Organism-specific databases

CTDi3559
MGIiMGI:96549 Il2ra

Phylogenomic databases

eggNOGiENOG410J24B Eukaryota
ENOG41116U7 LUCA
HOVERGENiHBG052109
KOiK05068
OMAiHYQCIQG
OrthoDBiEOG091G0NHH

Miscellaneous databases

ChiTaRSiIl2ra mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026770 Expressed in 32 organ(s), highest expression level in bone marrow

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR015486 IL-2_rcpt_alpha
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10573 PTHR10573, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ544I2_MOUSE
AccessioniPrimary (citable) accession number: Q544I2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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