UniProtKB - Q544E9 (Q544E9_MOUSE)
Protein
ADAM10-processed FasL form
Gene
Fasl
Organism
Mus musculus (Mouse)
Status
Functioni
Cytoplasmic form induces gene transcription inhibition.ARBA annotation
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- death receptor binding Source: Ensembl
- tumor necrosis factor receptor binding Source: Ensembl
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- cellular chloride ion homeostasis Source: Ensembl
- cellular response to interferon-gamma Source: Ensembl
- endosomal lumen acidification Source: Ensembl
- extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
- inflammatory cell apoptotic process Source: Ensembl
- necroptotic signaling pathway Source: Ensembl
- negative regulation of angiogenesis Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of endothelial cell apoptotic process Source: Ensembl
- positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- positive regulation of neuron apoptotic process Source: Ensembl
- release of sequestered calcium ion into cytosol by endoplasmic reticulum Source: Ensembl
- response to growth factor Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- T cell apoptotic process Source: Ensembl
Keywordsi
Molecular function | CytokineARBA annotation, RepressorARBA annotation |
Biological process | ApoptosisARBA annotation, Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: ADAM10-processed FasL formARBA annotationAlternative name(s): CD95 ligandARBA annotation Fas antigen ligandARBA annotation FasL intracellular domainARBA annotation Receptor-binding FasL ectodomainARBA annotation SPPL2A-processed FasL formARBA annotation Soluble Fas ligandARBA annotation Tumor necrosis factor ligand superfamily member 6ARBA annotation Tumor necrosis factor ligand superfamily member 6, membrane formARBA annotation Tumor necrosis factor ligand superfamily member 6, soluble formARBA annotation |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:99255, Fasl |
Subcellular locationi
Lysosome
- Lysosome lumen ARBA annotation
Extracellular region or secreted
- Secreted ARBA annotation
Nucleus
- Nucleus ARBA annotation
Other locations
- Cytoplasmic vesicle lumen ARBA annotation
Extracellular region or secreted
- extracellular exosome Source: Ensembl
Lysosome
- lysosomal lumen Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- caveola Source: Ensembl
Other locations
- cytoplasmic vesicle lumen Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 79 – 103 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cytoplasmic vesicleARBA annotation, LysosomeARBA annotation, Membrane, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000000817, Expressed in ectoplacental cone and 59 other tissues |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- death receptor binding Source: Ensembl
- tumor necrosis factor receptor binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 144 – 279 | TNF_2InterPro annotationAdd BLAST | 136 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 70 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 126 – 150 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 30 – 68 | Pro-richSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Belongs to the tumor necrosis factor family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_070352_2_0_1 |
OMAi | PQIFWVD |
OrthoDBi | 1029363at2759 |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR028326, FASL IPR006053, TNF IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PRINTSi | PR01681, FASLIGAND PR01234, TNECROSISFCT |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q544E9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQQPMNYPCP QIFWVDSSAT SSWAPPGSVF PCPSCGPRGP DQRRPPPPPP
60 70 80 90 100
PVSPLPPPSQ PLPLPPLTPL KKKDHNTNLW LPVVFFMVLV ALVGMGLGMY
110 120 130 140 150
QLFHLQKELA ELREFTNQSL KVSSFEKQIA NPSTPSEKKE PRSVAHLTGN
160 170 180 190 200
PHSRSIPLEW EDTYGTALIS GVKYKKGGLV INETGLYFVY SKVYFRGQSC
210 220 230 240 250
NNQPLNHKVY MRNSKYPEDL VLMEEKRLNY CTTGQIWAHS SYLGAVFNLT
260 270
SADHLYVNIS QLSLINFEES KTFFGLYKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK040139 mRNA Translation: BAC30520.1 AK141268 mRNA Translation: BAE24625.1 LN874390 mRNA Translation: CTQ86155.1 |
RefSeqi | NP_034307.1, NM_010177.4 |
Genome annotation databases
GeneIDi | 14103 |
KEGGi | mmu:14103 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK040139 mRNA Translation: BAC30520.1 AK141268 mRNA Translation: BAE24625.1 LN874390 mRNA Translation: CTQ86155.1 |
RefSeqi | NP_034307.1, NM_010177.4 |
3D structure databases
SMRi | Q544E9 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 4418, 1278 antibodies |
Genome annotation databases
GeneIDi | 14103 |
KEGGi | mmu:14103 |
Organism-specific databases
CTDi | 14103 |
MGIi | MGI:99255, Fasl |
Phylogenomic databases
HOGENOMi | CLU_070352_2_0_1 |
OMAi | PQIFWVD |
OrthoDBi | 1029363at2759 |
Miscellaneous databases
BioGRID-ORCSi | 14103, 0 hits in 17 CRISPR screens |
ChiTaRSi | Fasl, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000817, Expressed in ectoplacental cone and 59 other tissues |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR028326, FASL IPR006053, TNF IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PRINTSi | PR01681, FASLIGAND PR01234, TNECROSISFCT |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q544E9_MOUSE | |
Accessioni | Q544E9Primary (citable) accession number: Q544E9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |