UniProtKB - Q544E6 (Q544E6_MOUSE)
Protein
Submitted name:
Interleukin 17A
Gene
Il17a
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
GO - Biological processi
- fibroblast activation Source: Ensembl
- inflammatory response Source: InterPro
- interleukin-17-mediated signaling pathway Source: Ensembl
- positive regulation of chemokine (C-X-C motif) ligand 1 production Source: Ensembl
- positive regulation of cytokine production involved in inflammatory response Source: Ensembl
- positive regulation of interleukin-12 production Source: Ensembl
- positive regulation of interleukin-16 production Source: Ensembl
- positive regulation of interleukin-1 beta production Source: Ensembl
- positive regulation of interleukin-23 production Source: Ensembl
- positive regulation of interleukin-6 production Source: Ensembl
- positive regulation of osteoclast differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
Keywordsi
Molecular function | CytokineARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Interleukin 17AImported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:107364, Il17a |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_5014309618 | 26 – 158 | Sequence analysisAdd BLAST | 133 |
Keywords - PTMi
Disulfide bondARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000025929, Expressed in liver and 28 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-17 family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_118641_0_0_1 |
OMAi | CPHSFRL |
OrthoDBi | 1469254at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020440, IL-17_chr IPR010345, IL-17_fam |
Pfami | View protein in Pfam PF06083, IL17, 1 hit |
PRINTSi | PR01932, INTRLEUKIN17 |
SUPFAMi | SSF57501, SSF57501, 1 hit |
i Sequence
Sequence statusi: Complete.
Q544E6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPGRASSVS LMLLLLLSLA ATVKAAAIIP QSSACPNTEA KDFLQNVKVN
60 70 80 90 100
LKVFNSLGAK VSSRRPSDYL NRSTSPWTLH RNEDPDRYPS VIWEAQCRHQ
110 120 130 140 150
RCVNAEGKLD HHMNSVLIQQ EILVLKREPE SCPFTFRVEK MLVGVGCTCV
ASIVRQAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC119303 mRNA Translation: AAI19304.1 BC119309 mRNA Translation: AAI19310.1 AK040420 mRNA Translation: BAC30590.1 |
RefSeqi | NP_034682.1, NM_010552.3 |
Genome annotation databases
GeneIDi | 16171 |
KEGGi | mmu:16171 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC119303 mRNA Translation: AAI19304.1 BC119309 mRNA Translation: AAI19310.1 AK040420 mRNA Translation: BAC30590.1 |
RefSeqi | NP_034682.1, NM_010552.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 17132, 1814 antibodies |
Genome annotation databases
GeneIDi | 16171 |
KEGGi | mmu:16171 |
Organism-specific databases
CTDi | 3605 |
MGIi | MGI:107364, Il17a |
Phylogenomic databases
HOGENOMi | CLU_118641_0_0_1 |
OMAi | CPHSFRL |
OrthoDBi | 1469254at2759 |
Miscellaneous databases
BioGRID-ORCSi | 16171, 0 hits in 19 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025929, Expressed in liver and 28 other tissues |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020440, IL-17_chr IPR010345, IL-17_fam |
Pfami | View protein in Pfam PF06083, IL17, 1 hit |
PRINTSi | PR01932, INTRLEUKIN17 |
SUPFAMi | SSF57501, SSF57501, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q544E6_MOUSE | |
Accessioni | Q544E6Primary (citable) accession number: Q544E6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |