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Entry version 116 (12 Aug 2020)
Sequence version 2 (28 Nov 2002)
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Protein

Dextranase

Gene

dexA

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in sucrose-independent adherence to the pellicle-coated tooth surface.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endohydrolysis of (1->6)-alpha-D-glucosidic linkages in dextran. EC:3.2.1.11

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SMUT210007:G1FZX-1927-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.11, 5941

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH66, Glycoside Hydrolase Family 66

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dextranase (EC:3.2.1.11)
Alternative name(s):
Alpha-1,6-glucan-6-glucanohydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dexA
Ordered Locus Names:SMU_2042
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri210007 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002512 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – ?
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000012238? – 814Dextranase
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000012239815 – 850Removed by sortasePROSITE-ProRule annotationAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei814Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q54443

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
210007.SMU_2042

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1850
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54443

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi811 – 815LPXTG sorting signalPROSITE-ProRule annotation5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 66 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG5297, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_321569_0_0_9

KEGG Orthology (KO)

More...
KOi
K05988

Identification of Orthologs from Complete Genome Data

More...
OMAi
KFPRYGF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14745, GH66, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.1180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025092, Glyco_hydro_66
IPR013780, Glyco_hydro_b
IPR019948, Gram-positive_anchor
IPR013783, Ig-like_fold
IPR019931, LPXTG_anchor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13199, Glyco_hydro_66, 1 hit
PF00746, Gram_pos_anchor, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50847, GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q54443-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQSNRQTAE PAIRSAETVD STINSFQETD LKVQEKEDVA AAVQTESASI
60 70 80 90 100
DSNEQGQSVS ANTNTQSQAK KLSNNSHQEP MQMVSAANKE RAVLETAQNQ
110 120 130 140 150
KNGNMINLTT DKAVYQAGEA VHLNLTLNNT TSLAQNITAT AEVYSLENKL
160 170 180 190 200
KTLQYTKYLL PNESYTTQKG EFVIPANSLA NNRGYLLKVN ISDSQNNILE
210 220 230 240 250
QGNRAIAVED DWRTFPRYAA IGGSQKDNNS VLTKNLPDYY RELEQMKNMN
260 270 280 290 300
INSYFFYDVY KSATNPFPNV PKFDQSWNWW SHSQVETDAV KALVNRVHQT
310 320 330 340 350
GAVAMLYNMI LAQNANETAV LPDTEYIYNY ETGGYGQNGQ VMTYSIDDKP
360 370 380 390 400
LQYYYNPLSK SWQNYISNAM AQAMKNGGFD GWQGDTIGDN RVLSHNQKDS
410 420 430 440 450
RDIAHSFMLS DVYAEFLNKM KEKLPQYYLT LNDVNGENIS KLANSKQDVI
460 470 480 490 500
YNELWPFGTS ALGNRPQESY GDLKARVDQV RQATGKSLIV GAYMEEPKFD
510 520 530 540 550
DNRVPLNGAA RDVLASATYQ TDAVLLTTAA IAAAGGYHMS LAALANPNDG
560 570 580 590 600
GGVGVLETAY YPTQSLKVSK ELNRKNYHYQ QFITAYENLL RDKVENDSAE
610 620 630 640 650
PQTFTANGRQ LSQDALGING DQVWTYAKKG NDFRTIQLLN LMGITSDWKN
660 670 680 690 700
EDGYENNKTP DEQTNLLVTY PLTGVSMAEA DRIAKQVYLT SPDDWLQSSM
710 720 730 740 750
ISLATQIKTN ENGDPVLYIQ VPRLTLWDMI YINETIKPET PKVPEQPQHP
760 770 780 790 800
ARTLEPAIPQ TPEAVSPLPV ANKQAVDENK NEIVSALTGE ENDLQLPTLS
810 820 830 840 850
KRSLSISQAE LPQTGDNNET RSNLLKVIGA GALLIGAAGL LSLIKGRKKD
Length:850
Mass (Da):94,482
Last modified:November 28, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCF3E7DF7B4EA178
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16A → N (PubMed:8657012).Curated1
Sequence conflicti16A → N (PubMed:8535521).Curated1
Sequence conflicti22T → A (PubMed:8657012).Curated1
Sequence conflicti22T → A (PubMed:8535521).Curated1
Sequence conflicti39V → A (PubMed:8657012).Curated1
Sequence conflicti39V → A (PubMed:8535521).Curated1
Sequence conflicti56G → E (PubMed:8657012).Curated1
Sequence conflicti56G → E (PubMed:8535521).Curated1
Sequence conflicti67S → P (PubMed:8657012).Curated1
Sequence conflicti67S → P (PubMed:8535521).Curated1
Sequence conflicti141A → V (PubMed:8657012).Curated1
Sequence conflicti141A → V (PubMed:8535521).Curated1
Sequence conflicti376N → T (PubMed:8657012).Curated1
Sequence conflicti376N → T (PubMed:8535521).Curated1
Sequence conflicti504V → I (PubMed:8657012).Curated1
Sequence conflicti504V → I (PubMed:8535521).Curated1
Sequence conflicti704A → T (PubMed:8657012).Curated1
Sequence conflicti704A → T (PubMed:8535521).Curated1
Sequence conflicti707I → V (PubMed:8657012).Curated1
Sequence conflicti707I → V (PubMed:8535521).Curated1
Sequence conflicti776 – 778VDE → EDG (PubMed:8657012).Curated3
Sequence conflicti776 – 778VDE → EDG (PubMed:8535521).Curated3
Sequence conflicti783I → L (PubMed:8657012).Curated1
Sequence conflicti783I → L (PubMed:8535521).Curated1
Sequence conflicti849K → N (PubMed:8657012).Curated1
Sequence conflicti849K → N (PubMed:8535521).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D49430 Genomic DNA Translation: BAA08409.1
AE014133 Genomic DNA Translation: AAN59642.1

NCBI Reference Sequences

More...
RefSeqi
NP_722336.1, NC_004350.2
WP_011074684.1, NC_004350.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAN59642; AAN59642; SMU_2042

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
smu:SMU_2042

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|210007.7.peg.1820

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49430 Genomic DNA Translation: BAA08409.1
AE014133 Genomic DNA Translation: AAN59642.1
RefSeqiNP_722336.1, NC_004350.2
WP_011074684.1, NC_004350.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VMNX-ray1.60A100-732[»]
3VMOX-ray1.90A100-732[»]
3VMPX-ray1.88A100-732[»]
SMRiQ54443
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_2042

Protein family/group databases

CAZyiGH66, Glycoside Hydrolase Family 66

Proteomic databases

PRIDEiQ54443

Genome annotation databases

EnsemblBacteriaiAAN59642; AAN59642; SMU_2042
KEGGismu:SMU_2042
PATRICifig|210007.7.peg.1820

Phylogenomic databases

eggNOGiCOG5297, Bacteria
HOGENOMiCLU_321569_0_0_9
KOiK05988
OMAiKFPRYGF

Enzyme and pathway databases

BioCyciSMUT210007:G1FZX-1927-MONOMER
BRENDAi3.2.1.11, 5941

Family and domain databases

CDDicd14745, GH66, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR025092, Glyco_hydro_66
IPR013780, Glyco_hydro_b
IPR019948, Gram-positive_anchor
IPR013783, Ig-like_fold
IPR019931, LPXTG_anchor
PfamiView protein in Pfam
PF13199, Glyco_hydro_66, 1 hit
PF00746, Gram_pos_anchor, 1 hit
PROSITEiView protein in PROSITE
PS50847, GRAM_POS_ANCHORING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEXT_STRMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54443
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: August 12, 2020
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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