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UniProtKB - Q543Z1 (Q543Z1_MOUSE)
Protein
Carboxylic ester hydrolase
Gene
Ache
Organism
Mus musculus (Mouse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 234 | Acyl-ester intermediateUniRule annotation | 1 | |
Active sitei | 365 | Charge relay systemUniRule annotation | 1 | |
Active sitei | 478 | Charge relay systemUniRule annotation | 1 |
GO - Molecular functioni
- acetylcholine binding Source: Ensembl
- acetylcholinesterase activity Source: Ensembl
- collagen binding Source: Ensembl
- laminin binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- serine hydrolase activity Source: Ensembl
GO - Biological processi
- acetylcholine catabolic process Source: Ensembl
- cell adhesion Source: Ensembl
- osteoblast development Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Serine esteraseARBA annotation |
Protein family/group databases
ESTHERi | mouse-ACHE, AChE |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:AcheImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:87876, Ache |
VEuPathDBi | HostDB:ENSMUSG00000023328 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: Ensembl
Other locations
- membrane Source: Ensembl
- perinuclear region of cytoplasm Source: Ensembl
- synapse Source: Ensembl
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | UniRule annotationAdd BLAST | 31 | |
ChainiPRO_5014205864 | 32 – 614 | Carboxylic ester hydrolaseUniRule annotationAdd BLAST | 583 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000023328, Expressed in hypothalamus and 124 other tissues |
Interactioni
GO - Molecular functioni
- laminin binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 563 | COesteraseInterPro annotationAdd BLAST | 525 | |
Domaini | 578 – 611 | AChE_tetraInterPro annotationAdd BLAST | 34 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationPhylogenomic databases
OMAi | CDHLVAP |
OrthoDBi | 754103at2759 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR014788, AChE_tetra IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS IPR000997, Cholinesterase |
Pfami | View protein in Pfam PF08674, AChE_tetra, 1 hit PF00135, COesterase, 1 hit |
PRINTSi | PR00878, CHOLNESTRASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q543Z1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPPWYPLHT PSLAFPLLFL LLSLLGGGAR AEGREDPQLL VRVRGGQLRG
60 70 80 90 100
IRLKAPGGPV SAFLGIPFAE PPVGSRRFMP PEPKRPWSGV LDATTFQNVC
110 120 130 140 150
YQYVDTLYPG FEGTEMWNPN RELSEDCLYL NVWTPYPRPA SPTPVLIWIY
160 170 180 190 200
GGGFYSGAAS LDVYDGRFLA QVEGAVLVSM NYRVGTFGFL ALPGSREAPG
210 220 230 240 250
NVGLLDQRLA LQWVQENIAA FGGDPMSVTL FGESAGAASV GMHILSLPSR
260 270 280 290 300
SLFHRAVLQS GTPNGPWATV SAGEARRRAT LLARLVGCPP GGAGGNDTEL
310 320 330 340 350
IACLRTRPAQ DLVDHEWHVL PQESIFRFSF VPVVDGDFLS DTPEALINTG
360 370 380 390 400
DFQDLQVLVG VVKDEGSYFL VYGVPGFSKD NESLISRAQF LAGVRIGVPQ
410 420 430 440 450
ASDLAAEAVV LHYTDWLHPE DPTHLRDAMS AVVGDHNVVC PVAQLAGRLA
460 470 480 490 500
AQGARVYAYI FEHRASTLTW PLWMGVPHGY EIEFIFGLPL DPSLNYTTEE
510 520 530 540 550
RIFAQRLMKY WTNFARTGDP NDPRDSKSPQ WPPYTTAAQQ YVSLNLKPLE
560 570 580 590 600
VRRGLRAQTC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN
610
QFDHYSKQER CSDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK042335 mRNA Translation: BAC31228.1 AK043748 mRNA Translation: BAC31641.1 AK046080 mRNA Translation: BAC32595.1 AK140404 mRNA Translation: BAE24373.1 |
RefSeqi | NP_001276939.1, NM_001290010.1 NP_033729.1, NM_009599.4 |
Genome annotation databases
GeneIDi | 11423 |
KEGGi | mmu:11423 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK042335 mRNA Translation: BAC31228.1 AK043748 mRNA Translation: BAC31641.1 AK046080 mRNA Translation: BAC32595.1 AK140404 mRNA Translation: BAE24373.1 |
RefSeqi | NP_001276939.1, NM_001290010.1 NP_033729.1, NM_009599.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
ESTHERi | mouse-ACHE, AChE |
Protocols and materials databases
Antibodypediai | 16701, 779 antibodies from 43 providers |
DNASUi | 11423 |
Genome annotation databases
GeneIDi | 11423 |
KEGGi | mmu:11423 |
Organism-specific databases
CTDi | 43 |
MGIi | MGI:87876, Ache |
VEuPathDBi | HostDB:ENSMUSG00000023328 |
Phylogenomic databases
OMAi | CDHLVAP |
OrthoDBi | 754103at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11423, 3 hits in 76 CRISPR screens |
ChiTaRSi | Ache, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023328, Expressed in hypothalamus and 124 other tissues |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR014788, AChE_tetra IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS IPR000997, Cholinesterase |
Pfami | View protein in Pfam PF08674, AChE_tetra, 1 hit PF00135, COesterase, 1 hit |
PRINTSi | PR00878, CHOLNESTRASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q543Z1_MOUSE | |
Accessioni | Q543Z1Primary (citable) accession number: Q543Z1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |