UniProtKB - Q543V3 (Q543V3_MOUSE)
Protein
Submitted name:
Insulin receptor substrate 1
Gene
Irs1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- insulin-like growth factor receptor binding Source: Ensembl
- insulin receptor binding Source: Ensembl
- phosphatidylinositol 3-kinase binding Source: Ensembl
- phosphotyrosine residue binding Source: Ensembl
- signaling receptor complex adaptor activity Source: Ensembl
GO - Biological processi
- insulin-like growth factor receptor signaling pathway Source: Ensembl
- insulin receptor signaling pathway Source: Ensembl
- negative regulation of insulin secretion Source: Ensembl
- phosphatidylinositol 3-kinase signaling Source: Ensembl
- positive regulation of fatty acid beta-oxidation Source: Ensembl
- positive regulation of glucose import Source: Ensembl
- positive regulation of glycogen biosynthetic process Source: Ensembl
- positive regulation of insulin receptor signaling pathway Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Insulin receptor substrate 1Imported |
Gene namesi | Name:Irs1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99454, Irs1 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
Plasma Membrane
- caveola Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000055980, Expressed in pineal body and 280 other tissues |
Interactioni
GO - Molecular functioni
- insulin-like growth factor receptor binding Source: Ensembl
- insulin receptor binding Source: Ensembl
- phosphatidylinositol 3-kinase binding Source: Ensembl
- phosphotyrosine residue binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 115 | PHInterPro annotationAdd BLAST | 104 | |
Domaini | 155 – 259 | IRS-type PTBInterPro annotationAdd BLAST | 105 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 257 – 425 | DisorderedSequence analysisAdd BLAST | 169 | |
Regioni | 651 – 720 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 766 – 985 | DisorderedSequence analysisAdd BLAST | 220 | |
Regioni | 1015 – 1135 | DisorderedSequence analysisAdd BLAST | 121 | |
Regioni | 1174 – 1231 | DisorderedSequence analysisAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 261 – 276 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 288 – 311 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 362 – 425 | PolarSequence analysisAdd BLAST | 64 | |
Compositional biasi | 668 – 693 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 769 – 783 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 784 – 812 | PolarSequence analysisAdd BLAST | 29 | |
Compositional biasi | 867 – 883 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1029 – 1054 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1065 – 1083 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1202 – 1225 | PolarSequence analysisAdd BLAST | 24 |
Phylogenomic databases
GeneTreei | ENSGT00940000161579 |
HOGENOMi | CLU_004902_2_0_1 |
OMAi | YGKLWTN |
OrthoDBi | 298675at2759 |
TreeFami | TF325994 |
Family and domain databases
CDDi | cd01204, PTB_IRS, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR039011, IRS IPR002404, IRS_PTB IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR10614, PTHR10614, 1 hit |
Pfami | View protein in Pfam PF02174, IRS, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00628, INSULINRSI |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00310, PTBI, 1 hit |
PROSITEi | View protein in PROSITE PS51064, IRS_PTB, 1 hit PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q543V3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASPPDTDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE
60 70 80 90 100
KKWRHKSSAP KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE
110 120 130 140 150
AEQDSWYQAL LQLHNRAKAH HDGAGGGCGG SCSGSSGVGE AGEDLSYDTG
160 170 180 190 200
PGPAFKEVWQ VILKPKGLGQ TKNLIGIYRL CLTSKTISFV KLNSEAAAVV
210 220 230 240 250
LQLMNIRRCG HSENFFFIEV GRSAVTGPGE FWMQVDDSVV AQNMHETILE
260 270 280 290 300
AMRAMSDEFR PRSKSQSSSS CSNPISVPLR RHHLNNPPPS QVGLTRRSRT
310 320 330 340 350
ESITATSPAS MVGGKPGSFR VRASSDGEGT MSRPASVDGS PVSPSTNRTH
360 370 380 390 400
AHRHRGSSRL HPPLNHSRSI PMPSSRCSPS ATSPVSLSSS STSGHGSTSD
410 420 430 440 450
CLFPRRSSAS VSGSPSDGGF ISSDEYGSSP CDFRSSFRSV TPDSLGHTPP
460 470 480 490 500
ARGEEELSNY ICMGGKGAST LAAPNGHYIL SRGGNGHRYI PGANLGTSPA
510 520 530 540 550
LPGDEAAGAA DLDNRFRKRT HSAGTSPTIS HQKTPSQSSV ASIEEYTEMM
560 570 580 590 600
PAAYPPGGGS GGRLPGYRHS AFVPTHSYPE EGLEMHHLER RGGHHRPDTS
610 620 630 640 650
NLHTDDGYMP MSPGVAPVPS NRKGNGDYMP MSPKSVSAPQ QIINPIRRHP
660 670 680 690 700
QRVDPNGYMM MSPSGSCSPD IGGGSSSSSS ISAAPSGSSY GKPWTNGVGG
710 720 730 740 750
HHTHALPHAK PPVESGGGKL LPCTGDYMNM SPVGDSNTSS PSECYYGPED
760 770 780 790 800
PQHKPVLSYY SLPRSFKHTQ RPGEPEEGAR HQHLRLSSSS GRLRYTATAE
810 820 830 840 850
DSSSSTSSDS LGGGYCGARP ESSLTHPHHH VLQPHLPRKV DTAAQTNSRL
860 870 880 890 900
ARPTRLSLGD PKASTLPRVR EQQQQQQSSL HPPEPKSPGE YVNIEFGSGQ
910 920 930 940 950
PGYLAGPATS RSSPSVRCPP QLHPAPREET GSEEYMNMDL GPGRRATWQE
960 970 980 990 1000
SGGVELGRIG PAPPGSATVC RPTRSVPNSR GDYMTMQIGC PRQSYVDTSP
1010 1020 1030 1040 1050
VAPVSYADMR TGIAAEKASL PRPTGAAPPP SSTASSSVTP QGATAEQATH
1060 1070 1080 1090 1100
SSLLGGPQGP GGMSAFTRVN LSPNHNQSAK VIRADTQGCR RRHSSETFSA
1110 1120 1130 1140 1150
PTRAGNTVPF GAGAAVGGSG GGGGGGSEDV KRHSSASFEN VWLRPGDLGG
1160 1170 1180 1190 1200
VSKESAPVCG AAGGLEKSLN YIDLDLAKER SQDCPSQQQS LPPPPPHQPL
1210 1220 1230
GSNEGNSPRR SSEDLSNYAS ISFQKQPEDR Q
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP35569 | IRS1_MOUSE | Insulin receptor substrate 1 | Irs1 Irs-1 | 1,233 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC123690 Genomic DNA No translation available. AC137845 Genomic DNA No translation available. AK045317 mRNA Translation: BAC32308.1 AK142242 mRNA Translation: BAE24991.1 |
RefSeqi | NP_034700.2, NM_010570.4 |
Genome annotation databases
Ensembli | ENSMUST00000069799; ENSMUSP00000063795; ENSMUSG00000055980 |
GeneIDi | 16367 |
KEGGi | mmu:16367 |
UCSCi | uc007brp.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC123690 Genomic DNA No translation available. AC137845 Genomic DNA No translation available. AK045317 mRNA Translation: BAC32308.1 AK142242 mRNA Translation: BAE24991.1 |
RefSeqi | NP_034700.2, NM_010570.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3935, 2465 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000069799; ENSMUSP00000063795; ENSMUSG00000055980 |
GeneIDi | 16367 |
KEGGi | mmu:16367 |
UCSCi | uc007brp.2, mouse |
Organism-specific databases
CTDi | 3667 |
MGIi | MGI:99454, Irs1 |
Phylogenomic databases
GeneTreei | ENSGT00940000161579 |
HOGENOMi | CLU_004902_2_0_1 |
OMAi | YGKLWTN |
OrthoDBi | 298675at2759 |
TreeFami | TF325994 |
Miscellaneous databases
BioGRID-ORCSi | 16367, 4 hits in 17 CRISPR screens |
ChiTaRSi | Irs1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000055980, Expressed in pineal body and 280 other tissues |
Family and domain databases
CDDi | cd01204, PTB_IRS, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR039011, IRS IPR002404, IRS_PTB IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR10614, PTHR10614, 1 hit |
Pfami | View protein in Pfam PF02174, IRS, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00628, INSULINRSI |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00310, PTBI, 1 hit |
PROSITEi | View protein in PROSITE PS51064, IRS_PTB, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q543V3_MOUSE | |
Accessioni | Q543V3Primary (citable) accession number: Q543V3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |