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Protein

General transcription factor IIH subunit 4

Gene

Gtf2h4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4UniRule annotation
Gene namesi
Name:Gtf2h4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1338799 Gtf2h4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiQ542U3

Expressioni

Gene expression databases

BgeeiENSMUSG00000001524
ExpressionAtlasiQ542U3 baseline and differential

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3471 Eukaryota
COG5144 LUCA
HOVERGENiHBG054205
KOiK03144
OMAiYLEQYAH
OrthoDBiEOG091G06YE

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

Q542U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEITPARGGL NRAHLQCRNL QEFLGGLSPG VLDRLYGHPA TCLAVFRELP
60 70 80 90 100
SLAKNWVMRM LFLEQPLPQA AVALWVKKEF SKAQEESTGL LSGLRIWHTQ
110 120 130 140 150
LLPGGLQGLI LNPVFRQNLR IALLGGGKAW SDDTSQLGPD KHARDVPSLD
160 170 180 190 200
KYAEERWEVV LHFMVGSPSA AVSQDLAQLL SQAGLMKSTE PGEPPCITSA
210 220 230 240 250
GFQFLLLDTP AQLWYFMLQY LQTAQSRGMD LVEILSFLFQ LSFSTLGKDY
260 270 280 290 300
SVEGMSDSLL NFLQHLREFG LVFQRKRKSR RYYPTRLAIN LSSGVSGAGG
310 320 330 340 350
TVHQPGFIVV ETNYRLYAYT ESELQIALIA LFSEMLYRFP NMVVAQVTRE
360 370 380 390 400
SVQQAIASGI TAQQIIHFLR TRAHPVMLKQ NPVLPPTITD QIRLWELERD
410 420 430 440 450
RLRFTEGVLY NQFLSQVDFE LLLAHARELG VLVFENSAKR LMVVTPAGHS
460
DVKRFWKRQK HSS
Length:463
Mass (Da):52,224
Last modified:May 24, 2005 - v1
Checksum:iDBAA15CB388C5AFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079456 mRNA Translation: BAC37650.1
AK144680 mRNA Translation: BAE26009.1
AK146112 mRNA Translation: BAE26910.1
RefSeqiNP_034494.1, NM_010364.4
XP_006523731.1, XM_006523668.3
XP_006523732.1, XM_006523669.3
UniGeneiMm.10182

Genome annotation databases

GeneIDi14885
KEGGimmu:14885

Similar proteinsi

Entry informationi

Entry nameiQ542U3_MOUSE
AccessioniPrimary (citable) accession number: Q542U3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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