UniProtKB - Q542T9 (Q542T9_MOUSE)
Protein
Cyclin-dependent kinase 5 activator
Gene
Cdk5r1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- cadherin binding Source: Ensembl
- calcium ion binding Source: Ensembl
- cyclin-dependent protein serine/threonine kinase activator activity Source: Ensembl
- ephrin receptor binding Source: Ensembl
- kinase activity Source: UniProtKB-KW
- protein kinase binding Source: Ensembl
GO - Biological processi
- brain development Source: Ensembl
- embryo development ending in birth or egg hatching Source: Ensembl
- G protein-coupled acetylcholine receptor signaling pathway Source: Ensembl
- ionotropic glutamate receptor signaling pathway Source: Ensembl
- negative regulation of transcription, DNA-templated Source: Ensembl
- neuron projection development Source: Ensembl
- peptidyl-serine phosphorylation Source: Ensembl
- peptidyl-threonine phosphorylation Source: Ensembl
- positive regulation of neuron apoptotic process Source: Ensembl
- regulation of synaptic vesicle cycle Source: Ensembl
Keywordsi
Molecular function | CyclinImported, KinaseImported, Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase 5 activatorUniRule annotation |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:101764, Cdk5r1 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Lipid-anchor ARBA annotation; Cytoplasmic side ARBA annotation
Other locations
- Membrane ARBA annotation; Lipid-anchor ARBA annotation; Cytoplasmic side ARBA annotation
Nucleus
- nucleoplasm Source: Ensembl
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- contractile fiber Source: Ensembl
- dendritic spine Source: Ensembl
- growth cone Source: Ensembl
- neuromuscular junction Source: Ensembl
- neuronal cell body Source: Ensembl
- perinuclear region of cytoplasm Source: Ensembl
- postsynaptic density Source: Ensembl
- presynapse Source: Ensembl
- protein kinase 5 complex Source: UniProtKB-UniRule
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000048895, Expressed in striatum and 276 other tissues |
ExpressionAtlasi | Q542T9, baseline and differential |
Interactioni
Subunit structurei
Heterodimer of a catalytic subunit and a regulatory subunit.
UniRule annotationGO - Molecular functioni
- cadherin binding Source: Ensembl
- ephrin receptor binding Source: Ensembl
- protein kinase binding Source: Ensembl
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 97 – 133 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 111 – 129 | PolarSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_034132_2_0_1 |
OMAi | KNECSQE |
OrthoDBi | 1492547at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004944, CDK5_activator IPR036915, Cyclin-like_sf |
PANTHERi | PTHR23401, PTHR23401, 1 hit |
Pfami | View protein in Pfam PF03261, CDK5_activator, 1 hit |
PIRSFi | PIRSF009324, Cdk5_activator, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
i Sequence
Sequence statusi: Complete.
Q542T9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL
60 70 80 90 100
PWKRIVAVSA KKKNSKKAQP NSSYQSNIAH LNNENLKKSL SCANLSTFAQ
110 120 130 140 150
PPPAQPPAPP ASQLSGSQTG VSSSVKKAPH PAITSAGTPK RVIVQASTSE
160 170 180 190 200
LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS VDRSLLLQGW QDQGFITPAN
210 220 230 240 250
VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE ISYPLKPFLV
260 270 280 290 300
ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR
LLLGLDR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF121847 mRNA Translation: AAD21195.1 AK079557 mRNA Translation: BAC37683.1 AK141549 mRNA Translation: BAE24731.1 AK169667 mRNA Translation: BAE41289.1 |
RefSeqi | NP_034001.1, NM_009871.3 |
Genome annotation databases
GeneIDi | 12569 |
KEGGi | mmu:12569 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF121847 mRNA Translation: AAD21195.1 AK079557 mRNA Translation: BAC37683.1 AK141549 mRNA Translation: BAE24731.1 AK169667 mRNA Translation: BAE41289.1 |
RefSeqi | NP_034001.1, NM_009871.3 |
3D structure databases
SMRi | Q542T9 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q542T9 |
Protocols and materials databases
Antibodypediai | 15411, 274 antibodies |
Genome annotation databases
GeneIDi | 12569 |
KEGGi | mmu:12569 |
Organism-specific databases
CTDi | 8851 |
MGIi | MGI:101764, Cdk5r1 |
Phylogenomic databases
HOGENOMi | CLU_034132_2_0_1 |
OMAi | KNECSQE |
OrthoDBi | 1492547at2759 |
Miscellaneous databases
BioGRID-ORCSi | 12569, 1 hit in 17 CRISPR screens |
ChiTaRSi | Cdk5r1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000048895, Expressed in striatum and 276 other tissues |
ExpressionAtlasi | Q542T9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR004944, CDK5_activator IPR036915, Cyclin-like_sf |
PANTHERi | PTHR23401, PTHR23401, 1 hit |
Pfami | View protein in Pfam PF03261, CDK5_activator, 1 hit |
PIRSFi | PIRSF009324, Cdk5_activator, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q542T9_MOUSE | |
Accessioni | Q542T9Primary (citable) accession number: Q542T9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | February 10, 2021 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |