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UniProtKB - Q54258 (STRB1_STRGA)
Protein
Inosamine-phosphate amidinotransferase 1
Gene
strB1
Organism
Streptomyces glaucescens
Status
Functioni
Catalyzes two non-consecutive transamidination reactions. It converts scyllo-inosamine 4-phosphate into N-amidino-scyllo-inosamine 4-phosphate and N1-amidinostreptamine 6-phosphate into streptidine 6-phosphate (By similarity).
By similarityCatalytic activityi
- 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithineEC:2.1.4.2
: streptomycin biosynthesis Pathwayi
This protein is involved in the pathway streptomycin biosynthesis, which is part of Antibiotic biosynthesis.View all proteins of this organism that are known to be involved in the pathway streptomycin biosynthesis and in Antibiotic biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 179 | By similarity | 1 | |
Active sitei | 227 | By similarity | 1 | |
Active sitei | 332 | Amidino-cysteine intermediateBy similarity | 1 |
GO - Molecular functioni
- scyllo-inosamine-4-phosphate amidinotransferase activity Source: UniProtKB-EC
GO - Biological processi
- streptomycin biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Transferase |
Biological process | Antibiotic biosynthesis, Streptomycin biosynthesis |
Enzyme and pathway databases
BRENDAi | 2.1.4.2, 6022 |
UniPathwayi | UPA00066 |
Names & Taxonomyi
Protein namesi | Recommended name: Inosamine-phosphate amidinotransferase 1 (EC:2.1.4.2)Alternative name(s): Aminocyclitol amidinotransferase Short name: ADT Inosamine-phosphate amidinotransferase I |
Gene namesi | Name:strB1 |
Organismi | Streptomyces glaucescens |
Taxonomic identifieri | 1907 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215476 | 1 – 348 | Inosamine-phosphate amidinotransferase 1Add BLAST | 348 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 1907.SGLAU_01160 |
Family & Domainsi
Sequence similaritiesi
Belongs to the amidinotransferase family.Curated
Phylogenomic databases
eggNOGi | COG1834, Bacteria |
OMAi | GGFHCAT |
OrthoDBi | 592329at2 |
Family and domain databases
InterProi | View protein in InterPro IPR033195, AmidinoTrfase |
PANTHERi | PTHR10488, PTHR10488, 1 hit |
i Sequence
Sequence statusi: Complete.
Q54258-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLVSVHNEW DPLEEIIVGT AVGARVPRAD RSVFAVEYAD EYDSQDQVPA
60 70 80 90 100
GPYPDRVLKE TEEELHVLSE ELTKLGVTVR RPGQRDNSAL VATPDWQTDG
110 120 130 140 150
FHDYCPRDGL LAVGQTVIES PMALRARFLE SLAYKDILLE YFASGARWLS
160 170 180 190 200
APKPRLADEM YEPTAPAGQR LTDLEPVFDA ANVLRFGTDL LYLVSDSGNE
210 220 230 240 250
LGAKWLQSAL GSTYKVHPCR GLYASTHVDS TIVPLRPGLV LVNPARVNDD
260 270 280 290 300
NMPDFLRSWQ TVVCPELVDI GFTGDKPHCS VWIGMNLLVV RPDLAVVDRR
310 320 330 340
QTGLIKVLEK HGVDVLPLQL THSRTLGGGF HCATLDVRRT GSLETYRF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78974 Genomic DNA Translation: CAA55571.1 AJ006985 Genomic DNA Translation: CAA07380.1 |
PIRi | S44229 |
RefSeqi | WP_043497526.1, NZ_CP009438.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78974 Genomic DNA Translation: CAA55571.1 AJ006985 Genomic DNA Translation: CAA07380.1 |
PIRi | S44229 |
RefSeqi | WP_043497526.1, NZ_CP009438.1 |
3D structure databases
SMRi | Q54258 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 1907.SGLAU_01160 |
Phylogenomic databases
eggNOGi | COG1834, Bacteria |
OMAi | GGFHCAT |
OrthoDBi | 592329at2 |
Enzyme and pathway databases
UniPathwayi | UPA00066 |
BRENDAi | 2.1.4.2, 6022 |
Family and domain databases
InterProi | View protein in InterPro IPR033195, AmidinoTrfase |
PANTHERi | PTHR10488, PTHR10488, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STRB1_STRGA | |
Accessioni | Q54258Primary (citable) accession number: Q54258 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 11, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families